5D2N
 
 | | Crystal structure of C25-NLV-HLA-A2 complex | | Descriptor: | ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, C25 alpha, ... | | Authors: | Mariuzza, R.A, Yang, X. | | Deposit date: | 2015-08-05 | | Release date: | 2015-10-07 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.099 Å) | | Cite: | Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope.
J.Biol.Chem., 290, 2015
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1NBY
 | | Crystal Structure of HyHEL-63 complexed with HEL mutant K96A | | Descriptor: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | | Authors: | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | | Deposit date: | 2002-12-04 | | Release date: | 2003-04-01 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
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1NDG
 | | Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme | | Descriptor: | ACETIC ACID, Lysozyme C, antibody kappa light chain, ... | | Authors: | Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J. | | Deposit date: | 2002-12-09 | | Release date: | 2003-06-03 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | X-ray snapshots of the maturation of an antibody response to a protein antigen
Nat.Struct.Biol., 10, 2003
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1NBZ
 | | Crystal Structure of HyHEL-63 complexed with HEL mutant K97A | | Descriptor: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | | Authors: | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | | Deposit date: | 2002-12-04 | | Release date: | 2003-04-01 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
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1NDM
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1JWM
 | | Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1(HA peptide 306-318) with the Superantigen SEC3 | | Descriptor: | Enterotoxin type C-3, HA peptide, HLA class II histocompatibility antigen, ... | | Authors: | Sundberg, E.J, Andersen, P.S, Schlievert, P.M, Karjalainen, K, Mariuzza, R.A. | | Deposit date: | 2001-09-04 | | Release date: | 2003-07-08 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity
maturation
Structure, 11, 2003
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1AC6
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1A2Y
 | | HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3 | | Descriptor: | IGG1-KAPPA D1.3 FV (HEAVY CHAIN), IGG1-KAPPA D1.3 FV (LIGHT CHAIN), LYSOZYME, ... | | Authors: | Tsuchiya, D, Mariuzza, R.A. | | Deposit date: | 1998-01-13 | | Release date: | 1998-04-29 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | A mutational analysis of binding interactions in an antigen-antibody protein-protein complex.
Biochemistry, 37, 1998
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4K5U
 | | Recognition of the BG-H Antigen by a Lamprey Variable Lymphocyte Receptor | | Descriptor: | Variable lymphocyte receptor, beta-D-galactopyranose | | Authors: | Luo, M, Velikovsky, C.A, Yang, X.B, Mariuzza, R.A. | | Deposit date: | 2013-04-15 | | Release date: | 2013-06-26 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.698 Å) | | Cite: | Recognition of the thomsen-friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor.
J.Biol.Chem., 288, 2013
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8TXQ
 | | CryoEM structure of non-neutralizing antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2 | | Descriptor: | CBH-4B Heavy chain, CBH-4B Light chain, envelope glycoprotein E2 | | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | | Deposit date: | 2023-08-24 | | Release date: | 2024-08-28 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.
Commun Biol, 8, 2025
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8TZY
 | | CryoEM structure of non-neutralizing bivalent antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2 | | Descriptor: | CBH4B Heavy chain, CBH4B Light chain, envelope glycoprotein E2 | | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | | Deposit date: | 2023-08-28 | | Release date: | 2024-09-04 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.
Commun Biol, 8, 2025
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8U9Y
 | | CryoEM structure of neutralizing antibody HC84.26 in complex with Hepatitis C virus envelope glycoprotein E2_New interface | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... | | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | | Deposit date: | 2023-09-20 | | Release date: | 2024-09-25 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.
Commun Biol, 8, 2025
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7RM4
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3C8K
 | | The crystal structure of Ly49C bound to H-2Kb | | Descriptor: | H-2 class I histocompatibility antigen, K-B alpha chain, Natural killer cell receptor Ly-49C, ... | | Authors: | Deng, L, Mariuzza, R.A. | | Deposit date: | 2008-02-12 | | Release date: | 2008-04-15 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Molecular architecture of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors.
J.Biol.Chem., 283, 2008
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1SK4
 | | crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha | | Descriptor: | Peptidoglycan recognition protein I-alpha, SODIUM ION | | Authors: | Guan, R, Malchiodi, E.L, Qian, W, Schuck, P, Mariuzza, R.A. | | Deposit date: | 2004-03-04 | | Release date: | 2004-07-13 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha
J.Biol.Chem., 279, 2004
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7JTY
 | | Co-crystal structure of alpha glucosidase with compound 1 | | Descriptor: | (1S,2S,3R,4S,5S)-5-(butylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, Alpha glucosidase 2 alpha neutral subunit, ... | | Authors: | Karade, S.S, Mariuzza, R.A. | | Deposit date: | 2020-08-18 | | Release date: | 2021-10-13 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity.
J.Med.Chem., 64, 2021
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4ZSO
 | | Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ... | | Authors: | Xu, X, Li, Y, Mariuzza, R.A. | | Deposit date: | 2015-05-13 | | Release date: | 2016-05-18 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody
to be published
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8YJ3
 | | N17.1.2 recognition of NRAS neoantigens | | Descriptor: | tcr alpha, tcr beta | | Authors: | Wu, D.C, Mariuzza, R.A. | | Deposit date: | 2024-02-29 | | Release date: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (3.503 Å) | | Cite: | Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.
Sci Adv, 10, 2024
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8YJ2
 | | N17.1.2 recognition of NRAS neoantigens | | Descriptor: | Beta-2-microglobulin, ILE-LEU-ASP-THR-ALA-GLY-ARG-GLU-GLU-TYR, human leukocyte antigen, ... | | Authors: | Wu, D.C, Mariuzza, R.A. | | Deposit date: | 2024-02-29 | | Release date: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.261 Å) | | Cite: | Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.
Sci Adv, 10, 2024
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8YIV
 | | N17.1.2 recognition of NRAS neoantigens | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Wu, D.C, Mariuzza, R.A. | | Deposit date: | 2024-02-29 | | Release date: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.
Sci Adv, 10, 2024
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6X9X
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6WJU
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6WK4
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6WKL
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6WKM
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