7RM4
Neoantigen p53R175H-specific TCR 6-11 binds to p53R175H-HLA-A2
Summary for 7RM4
Entry DOI | 10.2210/pdb7rm4/pdb |
Descriptor | HLA class I histocompatibility antigen, A alpha chain, Beta-2-microglobulin, Cellular tumor antigen p53 peptide, ... (5 entities in total) |
Functional Keywords | tcr-pmhc, neoantigen, cancer, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 20 |
Total formula weight | 383411.36 |
Authors | Wu, D.,Mariuzza, R.A. (deposition date: 2021-07-26, release date: 2022-02-09, Last modification date: 2023-10-18) |
Primary citation | Wu, D.,Gowathaman, R.,Pierce, B.G.,Mariuzza, R.A. T cell receptors employ diverse strategies to target a p53 cancer neoantigen. J.Biol.Chem., 298:101684-101684, 2022 Cited by PubMed: 35124005DOI: 10.1016/j.jbc.2022.101684 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.33 Å) |
Structure validation
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