7RM4

Neoantigen p53R175H-specific TCR 6-11 binds to p53R175H-HLA-A2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F, K, P (A, F, K, P)	HLA class I histocompatibility antigen, A alpha chain	polymer	275	31854.2	4	UniProt (P04439) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (Human)	Human leukocyte antigen A,HLA-A
2	B, G, L, Q (B, G, L, Q)	Beta-2-microglobulin	polymer	100	11879.4	4	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C, H, M, R (C, H, M, R)	Cellular tumor antigen p53 peptide	polymer	9	1114.3	4	UniProt (P04637)	Homo sapiens (Human)	Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
4	D, I, N, S (D, I, N, S)	6-11 T cell receptor beta chain	polymer	246	27662.9	4		Homo sapiens (Human)
5	E, J, O, T (E, J, O, T)	6-11 T cell receptor alpha chain	polymer	206	23342.0	4		Homo sapiens (Human)

Sequence modifications

A, F, K, P: 1 - 275 (UniProt: P04439)

PDB	External Database	Details
Gly 62	Gln 86	conflict
Lys 66	Asn 90	conflict
His 70	Gln 94	conflict
His 74	Asp 98	conflict
Val 95	Ile 119	conflict
Arg 97	Ile 121	conflict
Trp 107	Gly 131	conflict
His 114	Arg 138	conflict
Tyr 116	Asp 140	conflict
Lys 127	Asn 151	conflict
Thr 142	Ile 166	conflict
His 145	Arg 169	conflict
Val 152	Glu 176	conflict
Glu 161	Asp 185	conflict
Ala 184	Pro 208	conflict
Ala 193	Pro 217	conflict
Val 194	Ile 218	conflict
Ser 207	Gly 231	conflict
Gln 253	Glu 277	conflict

B, G, L, Q: 2 - 100 (UniProt: P61769)

PDB	External Database	Details
Met 1	-	initiating methionine

C, H, M, R: 1 - 9 (UniProt: P04637)

PDB	External Database	Details
His 8	Arg 175	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	383411.4
All*	Total formula weight	383411.4

*Water molecules are not included.