7RM4
Neoantigen p53R175H-specific TCR 6-11 binds to p53R175H-HLA-A2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, F, K, P | HLA class I histocompatibility antigen, A alpha chain | polymer | 275 | 31854.2 | 4 | UniProt (P04439) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (Human) | Human leukocyte antigen A,HLA-A |
2 | B, G, L, Q | Beta-2-microglobulin | polymer | 100 | 11879.4 | 4 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C, H, M, R | Cellular tumor antigen p53 peptide | polymer | 9 | 1114.3 | 4 | UniProt (P04637) In PDB | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
4 | D, I, N, S | 6-11 T cell receptor beta chain | polymer | 246 | 27662.9 | 4 | Homo sapiens (Human) | ||
5 | E, J, O, T | 6-11 T cell receptor alpha chain | polymer | 206 | 23342.0 | 4 | Homo sapiens (Human) |
Sequence modifications
A, F, K, P: 1 - 275 (UniProt: P04439)
B, G, L, Q: 2 - 100 (UniProt: P61769)
C, H, M, R: 1 - 9 (UniProt: P04637)
PDB | External Database | Details |
---|---|---|
Gly 62 | Gln 86 | conflict |
Lys 66 | Asn 90 | conflict |
His 70 | Gln 94 | conflict |
His 74 | Asp 98 | conflict |
Val 95 | Ile 119 | conflict |
Arg 97 | Ile 121 | conflict |
Trp 107 | Gly 131 | conflict |
His 114 | Arg 138 | conflict |
Tyr 116 | Asp 140 | conflict |
Lys 127 | Asn 151 | conflict |
Thr 142 | Ile 166 | conflict |
His 145 | Arg 169 | conflict |
Val 152 | Glu 176 | conflict |
Glu 161 | Asp 185 | conflict |
Ala 184 | Pro 208 | conflict |
Ala 193 | Pro 217 | conflict |
Val 194 | Ile 218 | conflict |
Ser 207 | Gly 231 | conflict |
Gln 253 | Glu 277 | conflict |
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
His 8 | Arg 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 20 |
Total formula weight | 383411.4 | |
All* | Total formula weight | 383411.4 |