7JTY
Co-crystal structure of alpha glucosidase with compound 1
Summary for 7JTY
| Entry DOI | 10.2210/pdb7jty/pdb |
| Descriptor | Alpha glucosidase 2 alpha neutral subunit, Glucosidase 2 subunit beta, (1S,2S,3R,4S,5S)-5-(butylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, ... (8 entities in total) |
| Functional Keywords | alpha glucosidase ii, endoplasmic reticulum, inhibitor complex, hydrolase |
| Biological source | Mus musculus (Mouse) More |
| Total number of polymer chains | 4 |
| Total formula weight | 346139.20 |
| Authors | Karade, S.S.,Mariuzza, R.A. (deposition date: 2020-08-18, release date: 2021-10-13, Last modification date: 2023-10-18) |
| Primary citation | Karade, S.S.,Hill, M.L.,Kiappes, J.L.,Manne, R.,Aakula, B.,Zitzmann, N.,Warfield, K.L.,Treston, A.M.,Mariuzza, R.A. N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity. J.Med.Chem., 64:18010-18024, 2021 Cited by PubMed: 34870992DOI: 10.1021/acs.jmedchem.1c01377 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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