7JTY
Co-crystal structure of alpha glucosidase with compound 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0030246 | molecular_function | carbohydrate binding |
| B | 0001701 | biological_process | in utero embryonic development |
| B | 0001889 | biological_process | liver development |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0006491 | biological_process | N-glycan processing |
| B | 0010977 | biological_process | negative regulation of neuron projection development |
| B | 0017177 | cellular_component | glucosidase II complex |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0071941 | biological_process | nitrogen cycle metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0030246 | molecular_function | carbohydrate binding |
| D | 0001701 | biological_process | in utero embryonic development |
| D | 0001889 | biological_process | liver development |
| D | 0003723 | molecular_function | RNA binding |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0006491 | biological_process | N-glycan processing |
| D | 0010977 | biological_process | negative regulation of neuron projection development |
| D | 0017177 | cellular_component | glucosidase II complex |
| D | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| D | 0044877 | molecular_function | protein-containing complex binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0071941 | biological_process | nitrogen cycle metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DDNMDGMVSlaEL |
| Chain | Residue | Details |
| B | ASP222-LEU234 |
| site_id | PS00129 |
| Number of Residues | 8 |
| Details | GLYCOSYL_HYDROL_F31_1 Glycosyl hydrolases family 31 active site. YVWnDMNE |
| Chain | Residue | Details |
| A | TYR560-GLU567 |
| site_id | PS00707 |
| Number of Residues | 31 |
| Details | GLYCOSYL_HYDROL_F31_2 Glycosyl hydrolases family 31 signature 2. GADVGGFfknPepeLLvRWyqMGAYqPFfRA |
| Chain | Residue | Details |
| A | GLY667-ALA697 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10066, ECO:0000269|PubMed:27462106, ECO:0007744|PDB:5HJR |
| Chain | Residue | Details |
| A | ASP564 | |
| C | ASP564 | |
| D | ASP49 | |
| D | ASP53 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:27462106 |
| Chain | Residue | Details |
| A | ASP640 | |
| B | ASP104 | |
| B | GLU105 | |
| D | GLN50 | |
| D | TYR55 | |
| D | ASP57 | |
| D | ASP63 | |
| D | GLU64 | |
| D | ARG91 | |
| D | ASP94 | |
| D | VAL96 | |
| C | ASP640 | |
| D | ASP98 | |
| D | ASP104 | |
| D | GLU105 | |
| B | ASP57 | |
| B | ASP63 | |
| B | GLU64 | |
| B | ARG91 | |
| B | ASP94 | |
| B | VAL96 | |
| B | ASP98 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:27462106, ECO:0007744|PDB:5HJO |
| Chain | Residue | Details |
| A | ASP305 | |
| D | GLU233 | |
| A | ASP451 | |
| A | ARG624 | |
| A | HIS698 | |
| C | ASP305 | |
| C | ASP451 | |
| C | ARG624 | |
| C | HIS698 | |
| D | MET228 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q14697 |
| Chain | Residue | Details |
| A | SER52 | |
| C | SER52 | |
| D | SER24 | |
| D | SER168 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10921916, ECO:0000269|PubMed:27462106, ECO:0007744|PDB:5F0E, ECO:0007744|PDB:5HJO, ECO:0007744|PDB:5HJR, ECO:0007744|PDB:5IED, ECO:0007744|PDB:5IEE, ECO:0007744|PDB:5IEF, ECO:0007744|PDB:5IEG |
| Chain | Residue | Details |
| A | ASP97 | |
| C | ASP97 | |
| B | SER383 | |
| B | SER427 | |
| D | SER89 | |
| D | SER376 | |
| D | SER383 | |
| D | SER427 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| B | LYS166 | |
| D | LYS166 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN72 | |
| B | ASN469 | |
| D | ASN72 | |
| D | ASN469 |
