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1NYG
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BU of 1nyg by Molmil
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, FAMILY OF 20 STRUCTURES
Descriptor: FYN
Authors:Morton, C.J, Pugh, D.J.R, Campbell, I.D.
Deposit date:1996-04-22
Release date:1996-11-08
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure and peptide binding of the SH3 domain from human Fyn.
Structure, 4, 1996
1NYF
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BU of 1nyf by Molmil
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE
Descriptor: FYN
Authors:Morton, C.J, Pugh, D.J.R, Campbell, I.D.
Deposit date:1996-04-22
Release date:1996-11-08
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure and peptide binding of the SH3 domain from human Fyn.
Structure, 4, 1996
6XD4
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BU of 6xd4 by Molmil
CDC-like protein
Descriptor: ACETATE ION, Hemolysin, SODIUM ION
Authors:Morton, C.J, Parker, M.W, Lawrence, S.L, Johnstone, B.A, Tweten, R.K.
Deposit date:2020-06-09
Release date:2021-04-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins.
Mbio, 11, 2020
6NAL
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BU of 6nal by Molmil
Crystal Structure of Gram Negative Toxin
Descriptor: IMIDAZOLE, TETRAETHYLENE GLYCOL, Thiol-activated cytolysin
Authors:Morton, C.J, Lawrence, S.A, Parker, M.W.
Deposit date:2018-12-05
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin.
Mbio, 10, 2019
3CWM
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BU of 3cwm by Molmil
Crystal structure of alpha-1-antitrypsin complexed with citrate
Descriptor: Alpha-1-antitrypsin, CITRIC ACID
Authors:Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W.
Deposit date:2008-04-22
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
3CWL
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BU of 3cwl by Molmil
Crystal structure of alpha-1-antitrypsin, crystal form B
Descriptor: Alpha-1-antitrypsin, CHLORIDE ION
Authors:Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W.
Deposit date:2008-04-22
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
5IMT
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BU of 5imt by Molmil
Toxin receptor complex
Descriptor: CD59 glycoprotein, COPPER (II) ION, Intermedilysin, ...
Authors:Morton, C.J, Lawrence, S.L, Feil, S.C, Parker, M.W.
Deposit date:2016-03-06
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7001 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
7LXT
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BU of 7lxt by Molmil
Structure of Plasmodium falciparum 20S proteasome with bound bortezomib
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Morton, C.J, Metcalfe, R.D, Liu, B, Xie, S.C, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2021-03-05
Release date:2021-09-22
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc.Natl.Acad.Sci.USA, 118, 2021
3VDD
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BU of 3vdd by Molmil
Structure of HRV2 capsid complexed with antiviral compound BTA798
Descriptor: 3-ethoxy-6-{2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy}-1,2-benzoxazole, Protein VP1, Protein VP2, ...
Authors:Morton, C.J, Feil, S.C, Parker, M.W.
Deposit date:2012-01-05
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.
ACS Med Chem Lett, 3, 2012
6PRO
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BU of 6pro by Molmil
MnSOD from Geobacillus stearothermophilus
Descriptor: MANGANESE (II) ION, Superoxide dismutase
Authors:Adams, J.J, Morton, C.J, Parker, M.W.
Deposit date:2019-07-10
Release date:2020-05-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.263 Å)
Cite:The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited
Aust.J.Chem., 73, 2020
2A2R
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BU of 2a2r by Molmil
Crystal Structure of Glutathione Transferase Pi in complex with S-nitrosoglutathione
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, CALCIUM ION, ...
Authors:Parker, L.J, Morton, C.J, Adams, J.J, Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
2A2S
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BU of 2a2s by Molmil
Crystal Structure of Human Glutathione Transferase in complex with S-nitrosoglutathione in the absence of reducing agent
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, CALCIUM ION, ...
Authors:Parker, L.J, Morton, C.J, Adams, J.J, Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
1A0N
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BU of 1a0n by Molmil
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, FAMILY OF 25 STRUCTURES
Descriptor: FYN, PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR
Authors:Renzoni, D.A, Pugh, D.J.R, Siligardi, G, Das, P, Morton, C.J, Rossi, C, Waterfield, M.D, Campbell, I.D, Ladbury, J.E.
Deposit date:1997-12-05
Release date:1998-02-25
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry, 35, 1996
1AZG
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BU of 1azg by Molmil
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE
Descriptor: FYN, PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR
Authors:Renzoni, D.A, Pugh, D.J.R, Siligardi, G, Das, P, Morton, C.J, Rossi, C, Waterfield, M.D, Campbell, I.D, Ladbury, J.E.
Deposit date:1997-11-18
Release date:1998-02-25
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry, 35, 1996
8G32
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BU of 8g32 by Molmil
Pro-form of a CDCL short from E. anophelis
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Johnstone, B.A, Christie, M.P, Morton, C.J, Parker, M.W.
Deposit date:2023-02-06
Release date:2024-02-07
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria.
Nat Commun, 15, 2024
8G33
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BU of 8g33 by Molmil
Activated form of a CDCL long protein
Descriptor: Hemolysin
Authors:Johnstone, B.A, Christie, M.P, Morton, C.J, Parker, M.W.
Deposit date:2023-02-06
Release date:2024-02-07
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Activated form of a CDCL long protein
To Be Published
5TLQ
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BU of 5tlq by Molmil
Model structure of the oxidized PaDsbA1 and 3-[(2-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-4-amine complex
Descriptor: 3-[(2-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-4-amine, Thiol:disulfide interchange protein DsbA
Authors:Mohanty, B, Rimmer, K.A, McMahon, R.M, Headey, S.J, Vazirani, M, Shouldice, S.R, Coincon, M, Tay, S, Morton, C.J, Simpson, J.S, Martin, J.L, Scanlon, M.S.
Deposit date:2016-10-11
Release date:2017-04-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1.
PLoS ONE, 12, 2017
8TC9
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BU of 8tc9 by Molmil
Human asparaginyl-tRNA synthetase bound to OSM-S-106
Descriptor: Asparagine--tRNA ligase, cytoplasmic, GLYCEROL, ...
Authors:Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2023-06-30
Release date:2024-02-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Nat Commun, 15, 2024
8TC8
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BU of 8tc8 by Molmil
Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate
Descriptor: 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, Asparagine--tRNA ligase, cytoplasmic, ...
Authors:Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2023-06-30
Release date:2024-02-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Nat Commun, 15, 2024
8TC7
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BU of 8tc7 by Molmil
Human asparaginyl-tRNA synthetase, apo form
Descriptor: Asparagine--tRNA ligase, cytoplasmic, CHLORIDE ION, ...
Authors:Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2023-06-30
Release date:2024-02-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Nat Commun, 15, 2024
7ROR
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BU of 7ror by Molmil
Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP
Descriptor: 5'-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2021-08-02
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
7ROS
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BU of 7ros by Molmil
Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML901-Tyr
Descriptor: CHLORIDE ION, MAGNESIUM ION, Tyrosine--tRNA ligase, ...
Authors:Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2021-08-02
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
7ROU
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BU of 7rou by Molmil
Structure of human tyrosyl tRNA synthetase in complex with ML901-Tyr
Descriptor: SULFATE ION, Tyrosine--tRNA ligase, cytoplasmic, ...
Authors:Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2021-08-02
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
7ROT
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BU of 7rot by Molmil
Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr
Descriptor: CHLORIDE ION, MAGNESIUM ION, Tyrosine--tRNA ligase, ...
Authors:Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2021-08-02
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
1AOU
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BU of 1aou by Molmil
NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES
Descriptor: FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE
Authors:Mulhern, T.D, Shaw, G.L, Morton, C.J, Day, A.J, Campbell, I.D.
Deposit date:1997-07-10
Release date:1998-01-14
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Structure, 5, 1997

 

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