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4Q93
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CRYSTAL STRUCTURE OF RESVERATROL BOUND HUMAN TYROSYL TRNA SYNTHETASE
Descriptor:Tyrosine--tRNA ligase, cytoplasmic, RESVERATROL, ...
Authors:Mathew, S., Schimmel, P.
Deposit date:2014-04-28
Release date:2014-12-17
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Nature, 519, 2014
4QBT
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CRYSTAL STRUCTURE OF TYROSINE BOUND HUMAN TYROSYL TRNA SYNTHETASE
Descriptor:Tyrosine--tRNA ligase, cytoplasmic, PHOSPHATE ION, ...
Authors:Mathew, S., Schimmel, P.
Deposit date:2014-05-08
Release date:2014-12-17
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Nature, 519, 2014
5T5S
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A FRAGMENT OF A HUMAN TRNA SYNTHETASE
Descriptor:Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L., Schimmel, P.
Deposit date:2016-08-31
Release date:2016-11-30
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5T76
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A FRAGMENT OF A HUMAN TRNA SYNTHETASE
Descriptor:Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L., Schimmel, P.
Deposit date:2016-09-02
Release date:2016-11-30
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5V58
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CRYSTAL STRUCTURE OF HUMAN PROLYL-TRNA SYNTHETASE IN COMPLEX WITH AZE-SA
Descriptor:Bifunctional glutamate/proline--tRNA ligase, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine, ZINC ION
Authors:Zhou, H., Song, Y., Schimmel, P.
Deposit date:2017-03-13
Release date:2018-01-10
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
5V59
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CRYSTAL STRUCTURE OF CATALYTIC FRAGMENT OF HUMAN ALARS IN COMPLEX WITH AZE-SA
Descriptor:Alanine--tRNA ligase, cytoplasmic, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine
Authors:Zhou, H., Song, Y., Schimmel, P.
Deposit date:2017-03-13
Release date:2018-01-10
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Nat Commun, 8, 2017
1YFR
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CRYSTAL STRUCTURE OF ALANYL-TRNA SYNTHETASE IN COMPLEX WITH ATP AND MAGNESIUM
Descriptor:Alanyl-tRNA synthetase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Swairjo, M.A., Schimmel, P.R.
Deposit date:2005-01-03
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase.
Proc.Natl.Acad.Sci.USA, 102, 2005
1YFS
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THE CRYSTAL STRUCTURE OF ALANYL-TRNA SYNTHETASE IN COMPLEX WITH L-ALANINE
Descriptor:Alanyl-tRNA synthetase, ALANINE
Authors:Swairjo, M.A., Schimmel, P.R.
Deposit date:2005-01-03
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase.
Proc.Natl.Acad.Sci.USA, 102, 2005
1YFT
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THE CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF ALANYL-TRNA SYNTHETASE IN COMPLEX WTIH GLYCINE
Descriptor:Alanyl-tRNA synthetase, GLYCINE
Authors:Swairjo, M.A., Schimmel, P.R.
Deposit date:2005-01-03
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase.
Proc.Natl.Acad.Sci.USA, 102, 2005
1YGB
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CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF ALANYL-TRNA SYNTHETASE IN COMPLEX WITH L-SERINE
Descriptor:Alanyl-tRNA synthetase, SERINE
Authors:Swairjo, M.A., Schimmel, P.R.
Deposit date:2005-01-04
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase.
Proc.Natl.Acad.Sci.USA, 102, 2005
2GVK
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CRYSTAL STRUCTURE OF A DYE-DECOLORIZING PEROXIDASE (DYP) FROM BACTEROIDES THETAIOTAOMICRON VPI-5482 AT 1.6 A RESOLUTION
Descriptor:Heme peroxidase, CHLORIDE ION, SODIUM ION, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2006-05-02
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.
Proteins, 69, 2007
2HAG
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CRYSTAL STRUCTURE OF A PUTATIVE DYP-TYPE PEROXIDASE PROTEIN (SO_0740) FROM SHEWANELLA ONEIDENSIS AT 2.75 A RESOLUTION
Descriptor:Melanin biosynthesis protein TyrA, putative
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2006-06-12
Release date:2006-08-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.
Proteins, 69, 2007
2IIZ
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CRYSTAL STRUCTURE OF PUTATIVE MELANIN BIOSYNTHESIS PROTEIN TYRA WITH BOUND HEME (NP_716371.1) FROM SHEWANELLA ONEIDENSIS AT 2.30 A RESOLUTION
Descriptor:Melanin biosynthesis protein TyrA, putative, SODIUM ION, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2006-09-28
Release date:2006-11-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA.
Proteins, 69, 2007
4DPG
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CRYSTAL STRUCTURE OF HUMAN LYSRS: P38/AIMP2 COMPLEX I
Descriptor:Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, ...
Authors:Fang, P., Wang, J., Bennett, S.P., Guo, M.
Deposit date:2012-02-13
Release date:2013-02-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription.
Mol.Cell, 49, 2013
4EQE
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CRYSTAL STRUCTURE OF HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 (HINT1) FROM HUMAN COMPLEXED WITH LYS-AMS
Descriptor:Histidine triad nucleotide-binding protein 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
4EQG
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CRYSTAL STRUCTURE OF HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 (HINT1) FROM HUMAN COMPLEXED WITH ALA-AMS
Descriptor:Histidine triad nucleotide-binding protein 1, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
4EQH
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CRYSTAL STRUCTURE OF HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1 (HINT1) FROM HUMAN COMPLEXED WITH TRP-AMS
Descriptor:Histidine triad nucleotide-binding protein 1, 5'-O-[(L-TRYPTOPHYLAMINO)SULFONYL]ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.668 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
2G36
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CRYSTAL STRUCTURE OF TRYPTOPHANYL-TRNA SYNTHETASE (EC 6.1.1.2) (TRYPTOPHAN-TRNA LIGASE)(TRPRS) (TM0492) FROM THERMOTOGA MARITIMA AT 2.50 A RESOLUTION
Descriptor:Tryptophanyl-tRNA synthetase, IRON/SULFUR CLUSTER, TRYPTOPHAN
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2006-02-17
Release date:2006-03-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster.
Acta Crystallogr.,Sect.F, 66, 2010
2PME
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THE APO CRYSTAL STRUCTURE OF THE GLYCYL-TRNA SYNTHETASE
Descriptor:Glycyl-tRNA synthetase
Authors:Xie, W.
Deposit date:2007-04-21
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Long-range structural effects of a Charcot-Marie- Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2PMF
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THE CRYSTAL STRUCTURE OF A HUMAN GLYCYL-TRNA SYNTHETASE MUTANT
Descriptor:Glycyl-tRNA synthetase, CHLORIDE ION, GLYCEROL
Authors:Xie, W.
Deposit date:2007-04-21
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Long-range structural effects of a Charcot-Marie- Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2ZT5
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AP4A (COCRYSTALLIZED WITH ATP)
Descriptor:Glycyl-tRNA synthetase, BIS(ADENOSINE)-5'-TETRAPHOSPHATE
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT6
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AMPCPP
Descriptor:Glycyl-tRNA synthetase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT7
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH GLYCINE AND ATP
Descriptor:Glycyl-tRNA synthetase, GLYCINE, ADENOSINE-5'-TRIPHOSPHATE
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT8
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH GLY-AMP ANALOG
Descriptor:Glycyl-tRNA synthetase, [(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (aminoacetyl)sulfamate
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZXF
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AP4A (COCRYSTALLIZED WITH AP4A)
Descriptor:Glycyl-tRNA synthetase, BIS(ADENOSINE)-5'-TETRAPHOSPHATE
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-12-23
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published