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5D2N
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BU of 5d2n by Molmil
Crystal structure of C25-NLV-HLA-A2 complex
Descriptor: ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, C25 alpha, ...
Authors:Mariuzza, R.A, Yang, X.
Deposit date:2015-08-05
Release date:2015-10-07
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope.
J.Biol.Chem., 290, 2015
1NDG
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BU of 1ndg by Molmil
Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme
Descriptor: ACETIC ACID, Lysozyme C, antibody kappa light chain, ...
Authors:Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J.
Deposit date:2002-12-09
Release date:2003-06-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray snapshots of the maturation of an antibody response to a protein antigen
Nat.Struct.Biol., 10, 2003
1NBY
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BU of 1nby by Molmil
Crystal Structure of HyHEL-63 complexed with HEL mutant K96A
Descriptor: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain
Authors:Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J.
Deposit date:2002-12-04
Release date:2003-04-01
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
1NBZ
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BU of 1nbz by Molmil
Crystal Structure of HyHEL-63 complexed with HEL mutant K97A
Descriptor: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain
Authors:Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J.
Deposit date:2002-12-04
Release date:2003-04-01
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
1NDM
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BU of 1ndm by Molmil
Crystal structure of Fab fragment of antibody HyHEL-26 complexed with lysozyme
Descriptor: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain
Authors:Mariuzza, R.A, Li, Y, Li, H.
Deposit date:2002-12-09
Release date:2003-06-03
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray snapshots of the maturation of an antibody response to a protein antigen
Nat.Struct.Biol., 10, 2003
1KIP
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BU of 1kip by Molmil
FV MUTANT Y(B 32)A (VH DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME
Descriptor: LYSOZYME, MONOCLONAL ANTIBODY D1.3
Authors:Fields, B.A, Poljak, R.J, Mariuzza, R.A.
Deposit date:1996-10-23
Release date:1996-12-23
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Hydrogen bonding and solvent structure in an antigen-antibody interface. Crystal structures and thermodynamic characterization of three Fv mutants complexed with lysozyme.
Biochemistry, 35, 1996
1KIQ
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BU of 1kiq by Molmil
FV MUTANT Y(B 101)F (VH DOMAIN) OF MOUSE MONOCLONAL ANTIBODY D1.3 COMPLEXED WITH HEN EGG WHITE LYSOZYME
Descriptor: LYSOZYME, MONOCLONAL ANTIBODY D1.3
Authors:Fields, B.A, Poljak, R.J, Mariuzza, R.A.
Deposit date:1996-10-23
Release date:1996-12-23
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Hydrogen bonding and solvent structure in an antigen-antibody interface. Crystal structures and thermodynamic characterization of three Fv mutants complexed with lysozyme.
Biochemistry, 35, 1996
1TVD
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BU of 1tvd by Molmil
VARIABLE DOMAIN OF T CELL RECEPTOR DELTA CHAIN
Descriptor: T CELL RECEPTOR
Authors:Li, H.M, Lebedeva, M.I, Llera, A.S, Fields, B.A, Brenner, M.B, Mariuzza, R.A.
Deposit date:1997-10-19
Release date:1998-04-22
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Vdelta domain of a human gammadelta T-cell antigen receptor.
Nature, 391, 1998
5D2L
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BU of 5d2l by Molmil
Crystal structure of TCR C7 in complex with HCMV NLV epitope presented by HLA-A2
Descriptor: ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, C7 TCR alpha chain, ...
Authors:Gao, M, Mariuzza, R.A.
Deposit date:2015-08-05
Release date:2015-10-07
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.511 Å)
Cite:Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope.
J.Biol.Chem., 290, 2015
7RD2
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BU of 7rd2 by Molmil
Co-crystal structure of Chaetomium glucosidase with compound 2
Descriptor: (2R,3R,4R,5S)-1-{[4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-nitroanilino}methyl)phenyl]methyl}-2-(hydroxymethyl)piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chaetomium alpha glucosidase, ...
Authors:Karade, S.S, Mariuzza, R.A.
Deposit date:2021-07-09
Release date:2023-02-22
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity.
J.Med.Chem., 66, 2023
1AC6
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BU of 1ac6 by Molmil
CRYSTAL STRUCTURE OF A VARIABLE DOMAIN MUTANT OF A T-CELL RECEPTOR ALPHA CHAIN
Descriptor: T-CELL RECEPTOR ALPHA
Authors:Li, H.-M, Mariuzza, R.A.
Deposit date:1997-02-13
Release date:1998-02-25
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dual conformations of a T cell receptor V alpha homodimer: implications for variability in V alpha V beta domain association.
J.Mol.Biol., 269, 1997
1A2Y
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BU of 1a2y by Molmil
HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3
Descriptor: IGG1-KAPPA D1.3 FV (HEAVY CHAIN), IGG1-KAPPA D1.3 FV (LIGHT CHAIN), LYSOZYME, ...
Authors:Tsuchiya, D, Mariuzza, R.A.
Deposit date:1998-01-13
Release date:1998-04-29
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A mutational analysis of binding interactions in an antigen-antibody protein-protein complex.
Biochemistry, 37, 1998
1TWQ
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BU of 1twq by Molmil
Crystal structure of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with PGN analog muramyl tripeptide
Descriptor: N-acetyl-beta-muramic acid, NICKEL (II) ION, muramyl tripeptide, ...
Authors:Guan, R, Roychowdury, A, Boons, G.-A, Mariuzza, R.A.
Deposit date:2004-07-01
Release date:2004-12-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for peptidoglycan binding by peptidoglycan recognition proteins
Proc.Natl.Acad.Sci.USA, 101, 2004
7JTY
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BU of 7jty by Molmil
Co-crystal structure of alpha glucosidase with compound 1
Descriptor: (1S,2S,3R,4S,5S)-5-(butylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, Alpha glucosidase 2 alpha neutral subunit, ...
Authors:Karade, S.S, Mariuzza, R.A.
Deposit date:2020-08-18
Release date:2021-10-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity.
J.Med.Chem., 64, 2021
7RM4
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BU of 7rm4 by Molmil
Neoantigen p53R175H-specific TCR 6-11 binds to p53R175H-HLA-A2
Descriptor: 6-11 T cell receptor alpha chain, 6-11 T cell receptor beta chain, Beta-2-microglobulin, ...
Authors:Wu, D, Mariuzza, R.A.
Deposit date:2021-07-26
Release date:2022-02-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:T cell receptors employ diverse strategies to target a p53 cancer neoantigen.
J.Biol.Chem., 298, 2022
2IAM
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BU of 2iam by Molmil
Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
Descriptor: 15-mer peptide from Triosephosphate isomerase, CD4+ T cell receptor E8 alpha chain, CD4+ T cell receptor E8 beta chain, ...
Authors:Deng, L, Langley, R.J, Mariuzza, R.A.
Deposit date:2006-09-08
Release date:2007-04-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor
Nat.Immunol., 8, 2007
2IAN
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BU of 2ian by Molmil
Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
Descriptor: 15-mer peptide from Triosephosphate isomerase, CD4+ T cell receptor E8 alpha chain, CD4+ T cell receptor E8 beta chain, ...
Authors:Deng, L, Langley, R.J, Mariuzza, R.A.
Deposit date:2006-09-08
Release date:2007-04-03
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor
Nat.Immunol., 8, 2007
8YJ3
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BU of 8yj3 by Molmil
N17.1.2 recognition of NRAS neoantigens
Descriptor: tcr alpha, tcr beta
Authors:Wu, D.C, Mariuzza, R.A.
Deposit date:2024-02-29
Release date:2024-12-04
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.
Sci Adv, 10, 2024
8YJ2
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BU of 8yj2 by Molmil
N17.1.2 recognition of NRAS neoantigens
Descriptor: Beta-2-microglobulin, ILE-LEU-ASP-THR-ALA-GLY-ARG-GLU-GLU-TYR, human leukocyte antigen, ...
Authors:Wu, D.C, Mariuzza, R.A.
Deposit date:2024-02-29
Release date:2024-12-04
Method:X-RAY DIFFRACTION (2.261 Å)
Cite:Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.
Sci Adv, 10, 2024
8YIV
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BU of 8yiv by Molmil
N17.1.2 recognition of NRAS neoantigens
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ...
Authors:Wu, D.C, Mariuzza, R.A.
Deposit date:2024-02-29
Release date:2024-12-04
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens.
Sci Adv, 10, 2024
1KTK
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BU of 1ktk by Molmil
Complex of Streptococcal pyrogenic enterotoxin C (SpeC) with a human T cell receptor beta chain (Vbeta2.1)
Descriptor: Exotoxin type C, T-cell receptor beta chain
Authors:Sundberg, E.J, Li, H, Llera, A.S, McCormick, J.K, Tormo, J, Karjalainen, K, Schlievert, P.M, Mariuzza, R.A.
Deposit date:2002-01-16
Release date:2002-06-07
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.
Structure, 10, 2002
1L0Y
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BU of 1l0y by Molmil
T cell receptor beta chain complexed with superantigen SpeA soaked with zinc
Descriptor: 14.3.d T cell receptor beta chain, Exotoxin type A, GLYCEROL, ...
Authors:Li, H, Sundberg, E.J, Mariuzza, R.A.
Deposit date:2002-02-14
Release date:2002-04-03
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.
Structure, 10, 2002
3T0E
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BU of 3t0e by Molmil
Crystal structure of a complete ternary complex of T cell receptor, peptide-MHC and CD4
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y, Mariuzza, R.A.
Deposit date:2011-07-20
Release date:2012-03-07
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.
Proc.Natl.Acad.Sci.USA, 109, 2012
8TXQ
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BU of 8txq by Molmil
CryoEM structure of non-neutralizing antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2
Descriptor: CBH-4B Heavy chain, CBH-4B Light chain, envelope glycoprotein E2
Authors:Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A.
Deposit date:2023-08-24
Release date:2024-08-28
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.
Commun Biol, 8, 2025
8TZY
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BU of 8tzy by Molmil
CryoEM structure of non-neutralizing bivalent antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2
Descriptor: CBH4B Heavy chain, CBH4B Light chain, envelope glycoprotein E2
Authors:Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A.
Deposit date:2023-08-28
Release date:2024-09-04
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.
Commun Biol, 8, 2025

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