Author results

4N77
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CRYSTAL STRUCTURE OF CAS PROTEIN
分子名称:Uncharacterized protein
著者Tian, W., Sheng, G., Zhao, H., Wang, J., Wang, Y.
登録日2013-10-15
公開日2014-10-15
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Crystal strucute studies of CasD
To be Published
4RL1
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF A LOADING ACYLTRANSFERASE FROM THE AVERMECTIN MODULAR POLYKETIDE SYNTHASE
分子名称:Type I polyketide synthase AVES 1
著者Wang, F., Wang, Y., Zheng, J.
登録日2014-10-15
公開日2015-01-28
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase.
Acs Chem.Biol., 10, 2015
4WGI
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A SINGLE DIASTEREOMER OF A MACROLACTAM CORE BINDS SPECIFICALLY TO MYELOID CELL LEUKEMIA 1 (MCL1)
分子名称:Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, MALTOSE, (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, ...
著者Clifton, M.C., Fairman, J.W., Fang, C., D'Souza, B., Fulroth, B., Leed, A., McCarren, P., Wang, L., Wang, Y., Kaushik, V., Palmer, M., Wei, G., Golub, T.R., Hubbard, B.K., Serrano-Wu, M.H.
登録日2014-09-18
公開日2014-11-19
最終更新日2014-12-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).
Acs Med.Chem.Lett., 5, 2014
4WHF
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CRYSTAL STRUCTURE OF TR3 LBD IN COMPLEX WITH 1-(3,4,5-TRIHYDROXYPHENYL)DECAN-1-ONE
分子名称:Nuclear receptor subfamily 4 group A member 1, GLYCEROL, 1-(3,4,5-trihydroxyphenyl)decan-1-one
著者Li, F.W., Cai, Q.X., Li, A.Z., Tian, X.Y., Wang, W.J., Wang, Y., Hou, P.P., Wu, Q., Lin, T.W.
登録日2014-09-22
公開日2015-09-09
最終更新日2015-10-14
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity
Chem.Biol., 22, 2015
4WHG
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CRYSTAL STRUCTURE OF TR3 LBD IN COMPLEX WITH MOLECULE 3
分子名称:Nuclear receptor subfamily 4 group A member 1, GLYCEROL, 1-(3,4,5-trihydroxyphenyl)octan-1-one
著者Li, F.W., Cai, Q.X., Li, A.Z., Tian, X.Y., Wang, W.J., Wang, Y., Hou, P.P., Wu, Q., Lin, T.W.
登録日2014-09-22
公開日2015-09-09
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity
Chem.Biol., 22, 2015
4XKL
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CRYSTAL STRUCTURE OF NDP52 ZF2 IN COMPLEX WITH MONO-UBIQUITIN
分子名称:Ubiquitin, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL, ...
著者Xie, X., Li, F., Wang, Y., Lin, Z., Chen, X., Liu, J., Pan, L.
登録日2015-01-12
公開日2015-11-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2
Autophagy, 11, 2015
5FBJ
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COMPLEX STRUCTURE OF JMJD5 AND SUBSTRATE
分子名称:Lysine-specific demethylase 8, 2-OXOGLUTARIC ACID, (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, ...
著者Liu, H.L., Wang, Y., Wang, C., Zhang, G.Y.
登録日2015-12-14
公開日2016-12-14
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献to be published
To Be Published
5UY8
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CRYSTAL STRUCTURE OF AICARFT BOUND TO AN ANTIFOLATE
分子名称:Bifunctional purine biosynthesis protein PURH, 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ...
著者Wang, J., Wang, Y., Fales, K.R., Atwell, S., Clawson, D.
登録日2017-02-23
公開日2018-01-10
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J. Med. Chem., 60, 2017
5UZ0
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CRYSTAL STRUCTURE OF AICARFT BOUND TO AN ANTIFOLATE
分子名称:Bifunctional purine biosynthesis protein PURH, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, MAGNESIUM ION, ...
著者Atwell, S., Wang, Y., Fales, K.R., Clawson, D., Wang, J.
登録日2017-02-24
公開日2018-01-10
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J. Med. Chem., 60, 2017
5V9U
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-1620 COVALENTLY BOUND TO K-RAS G12C
分子名称:GTPase KRas, CALCIUM ION, (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, ...
著者Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.
登録日2017-03-23
公開日2018-02-07
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
5WTJ
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CRYSTAL STRUCTURE OF AN ENDONUCLEASE
分子名称:CRISPR-associated endoribonuclease C2c2
著者Liu, L., Wang, Y.
登録日2016-12-13
公開日2017-02-08
最終更新日2017-08-30
実験手法X-RAY DIFFRACTION (3.503 Å)
主引用文献Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
Cell, 168, 2017
5WTK
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CRYSTAL STRUCTURE OF RNP COMPLEX
分子名称:CRISPR-associated endoribonuclease C2c2, RNA (58-MER)
著者Liu, L., Wang, Y.
登録日2016-12-13
公開日2017-02-08
実験手法X-RAY DIFFRACTION (2.651 Å)
主引用文献Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
Cell, 168, 2017
5XOU
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 7T8 ON THE GUIDE STRAND
分子名称:TtAgo (D546N), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*TP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Wang, J., Zhao, H., Wang, Y.
登録日2017-05-31
公開日2017-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
5XOW
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 6'A7' ON THE TARGET STRAND
分子名称:TtAgo (D546N), DNA (5'-D(P*(TD)P*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), RNA (5'-R(P*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*AP*CP*CP*UP*CP*G)-3'), ...
著者Sheng, G., Wang, J., Zhao, H., Wang, Y.
登録日2017-05-31
公開日2017-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.902 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
5XP8
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 4A5 ON THE GUIDE STRAND
分子名称:TtAgo, DNA (5'-D(P*TP*GP*AP*GP*AP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*CP*AP*AP*CP*C*AP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, J.D., Wang, Y.
登録日2017-06-01
公開日2018-04-18
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
5XPA
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 9'U10' ON THE TARGET STRAND
分子名称:Uncharacterized protein Ago, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), RNA (5'-R(P*AP*UP*AP*CP*AP*AP*CP*CP*GP*UP*UP*CP*UP*AP*CP*UP*CP*CP*G)-3'), ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, J.D., Wang, Y.
登録日2017-06-01
公開日2018-04-18
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
5XPG
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 6'U7' ON THE TARGET STRAND
分子名称:Uncharacterized protein, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*A P*GP*T)-3', 5'-R(*UP*AP*U*AP*CP*AP*AP*CP*CP*UP*AP*CP*AP*UP*AP*CP*CP*UP*CP* G)-3', ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, J.D., Wang, Y.
登録日2017-06-02
公開日2018-04-18
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
5XQ2
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 5A6 ON THE GUIDE STRAND
分子名称:TtAgo (D546N), DNA (5'-D(P*TP*GP*AP*AP*GP*AP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, D., Wang, Y.
登録日2017-06-06
公開日2017-10-04
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
5XWP
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CRYSTAL STRUCTURE OF LBUCAS13A-CRRNA-TARGET RNA TERNARY COMPLEX
分子名称:Uncharacterized protein, RNA (59-MER), RNA (30-MER)
著者Liu, L., Li, X., Li, Z., Wang, Y.
登録日2017-06-30
公開日2017-09-13
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.086 Å)
主引用文献The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a.
Cell, 170, 2017
6JDJ
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CRYSTAL STRUCTURE OF ACRIIC2 DIMER IN COMPLEX WITH PARTIAL NME1CAS9
分子名称:AcrIIC2, CRISPR-associated endonuclease Cas9
著者Cheng, Z., Huang, X., Sun, W., Wang, Y.
登録日2019-02-01
公開日2019-05-15
最終更新日2019-07-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.
Nat Commun, 10, 2019
6JDX
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CRYSTAL STRUCTURE OF ACRIIC2 DIMER IN COMPLEX WITH PARTIAL NME1CAS9 PREPROCESSED WITH PROTEASE ALPHA-CHYMOTRYPSIN
分子名称:AcrIIC2, CRISPR-associated endonuclease Cas9, 1,2-ETHANEDIOL
著者Cheng, Z., Huang, X., Sun, W., Wang, Y.
登録日2019-02-02
公開日2019-05-15
最終更新日2019-08-28
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.
Nat Commun, 10, 2019
3PMR
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CRYSTAL STRUCTURE OF E2 DOMAIN OF HUMAN AMYLOID PRECURSOR-LIKE PROTEIN 1
分子名称:Amyloid-like protein 1, PHOSPHATE ION
著者Lee, S., Xue, Y., Hu, J., Wang, Y., Liu, X., Demeler, B., Ha, Y.
登録日2010-11-17
公開日2011-06-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization.
Biochemistry, 50, 2011
4OJV
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CRYSTAL STRUCTURE OF UNLIGANDED YEAST PDE1
分子名称:3',5'-cyclic-nucleotide phosphodiesterase 1, SULFATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
著者Tian, Y., Cui, W., Huang, M., Robinson, H., Wan, Y., Wang, Y., Ke, H.
登録日2014-01-21
公開日2014-12-03
最終更新日2015-07-01
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate.
Biochemistry, 53, 2014
4OJX
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CRYSTAL STRUCTURE OF YEAST PHOSPHODIESTERASE-1 IN COMPLEX WITH GMP
分子名称:3',5'-cyclic-nucleotide phosphodiesterase 1, (4S)-2-METHYL-2,4-PENTANEDIOL, GUANOSINE-5'-MONOPHOSPHATE, ...
著者Tian, Y., Cui, W., Huang, M., Robinson, H., Wan, Y., Wang, Y., Ke, H.
登録日2014-01-21
公開日2014-12-03
最終更新日2015-07-01
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate.
Biochemistry, 53, 2014
1A8E
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HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE
分子名称:SERUM TRANSFERRIN, CARBONATE ION, FE (III) ION
著者Macgillivray, R.T.A., Moore, S.A., Chen, J., Anderson, B.F., Baker, H., Luo, Y., Bewley, M., Smith, C.A., Murphy, M.E.P., Wang, Y., Mason, A.B., Woodworth, R.C., Brayer, G.D., Baker, E.N.
登録日1998-03-24
公開日1998-06-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.
Biochemistry, 37, 1998