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5TWM
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(TERT-BUTYLCARBAMOYL)PHENYL]-6-(ETHYLAMINO)-2-(4-FLUOROPHENYL)-N-METHYLFURO[2,3-B]PYRIDINE-3-CARBOXAMIDE
Descriptor:NS5B RNA-dependent RNA POLYMERASE, 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2016-11-14
Release date:2017-03-15
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Medchemcomm, 8, 2017
5TWN
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(TERT-BUTYLCARBAMOYL)PHENYL]-6-(ETHYLAMINO)-2-(4-FLUOROPHENYL)-N-METHYLFURO[2,3-B]PYRIDINE-3-CARBOXAMIDE
Descriptor:NS5B RNA- DEPENDENT RNA POLYMERASE, (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2016-11-14
Release date:2017-03-15
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Medchemcomm, 8, 2017
5WXH
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CRYSTAL STRUCTURE OF TAF3 PHD FINGER BOUND TO H3K4ME3
Descriptor:Transcription initiation factor TFIID subunit 3, Histone H3K4me3, ZINC ION
Authors:Zhao, S., Huang, J., Li, H.
Deposit date:2017-01-07
Release date:2017-08-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.297 Å)
Cite:Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6BKB
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STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE FROM GENOTYPE 6A BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3A
Descriptor:Fab AR3A heavy chain, Polyprotein, Fab AR3A light chain, ...
Authors:Tzarum, N., Wilson, I.A., Law, M.
Deposit date:2017-11-08
Release date:2018-12-26
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.
Sci Adv, 5, 2019
6BKC
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STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE FROM GENOTYPE 6A BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3B
Descriptor:Fab AR3B heavy chain, Fab AR3B light chain, Polyprotein, ...
Authors:Tzarum, N., Wilson, I.A., Law, M.
Deposit date:2017-11-08
Release date:2018-12-26
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.
Sci Adv, 5, 2019
6BKD
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STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE FROM GENOTYPE 6A BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3D
Descriptor:Polyprotein, Fab AR3D heavy chain, Fab AR3D light chain, ...
Authors:Tzarum, N., Wilson, I.A., Law, M.
Deposit date:2017-11-08
Release date:2018-12-26
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.
Sci Adv, 5, 2019
6DTL
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MITOGEN-ACTIVATED PROTEIN KINASE 6
Descriptor:Mitogen-activated protein kinase 6
Authors:Ruble, J.
Deposit date:2018-06-17
Release date:2019-05-15
Method:X-RAY DIFFRACTION (2.753 Å)
Cite:Bipartite anchoring of SCREAM enforces stomatal initiation by coupling MAP Kinases to SPEECHLESS
Nat.Plants, 2019
3DBD
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CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND 094
Descriptor:Polo-like kinase 1, 3'-chloro-5'-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)biphenyl-2-carboxamide
Authors:Elling, R.A., Barr, K.J., Romanowski, M.J.
Deposit date:2008-05-31
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
3DBE
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CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND 557
Descriptor:Polo-like kinase 1, 3'-chloro-5'-[6-({2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)-3-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl]biphenyl-2-carboxamide
Authors:Elling, R.A., Barr, K.J., Romanowski, M.J.
Deposit date:2008-05-31
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
3NGB
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV-1 GP120
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Zhou, T., Kwong, P.D.
Deposit date:2010-06-11
Release date:2010-07-07
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.
Science, 329, 2010
3TGQ
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CRYSTAL STRUCTURE OF UNLIGANDED HIV-1 CLADE B STRAIN YU2 GP120 CORE
Descriptor:HIV-1 YU2 gp120, N-ACETYL-D-GLUCOSAMINE
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2011-08-17
Release date:2012-04-04
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TGR
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CRYSTAL STRUCTURE OF UNLIGANDED HIV-1 CLADE C STRAIN C1086 GP120 CORE
Descriptor:HIV-1 clade C1086 gp120, N-ACETYL-D-GLUCOSAMINE
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2011-08-17
Release date:2012-04-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TGS
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CRYSTAL STRUCTURE OF HIV-1 CLADE C STRAIN C1086 GP120 CORE IN COMPLEX WITH NBD-556
Descriptor:HIV-1 clade C1086 gp120 core, N-ACETYL-D-GLUCOSAMINE, N-(4-chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)ethanediamide
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2011-08-17
Release date:2012-04-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TGT
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CRYSTAL STRUCTURE OF UNLIGANDED HIV-1 CLADE A/E STRAIN 93TH057 GP120 CORE
Descriptor:HIV-1 clade A/E 93TH057 gp120, N-ACETYL-D-GLUCOSAMINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2011-08-17
Release date:2012-04-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TIH
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CRYSTAL STRUCTURE OF UNLIGANDED HIV-1 CLADE C STRAIN ZM109F.PB4 GP120 CORE
Descriptor:HIV-1 clade C ZM109F.PB4 gp120
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2011-08-20
Release date:2012-04-04
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (4 Å)
Cite:Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Proc.Natl.Acad.Sci.USA, 109, 2012
4LSP
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-CH31 IN COMPLEX WITH HIV-1 CLADE A/E GP120 93TH057
Descriptor:HIV-1 CLADE A/E STRAIN 93TH057 GP120, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-09-04
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSQ
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-CH31 IN COMPLEX WITH HIV-1 CLADE A/E GP120 93TH057 WITH LOOP D AND LOOP V5 FROM CLADE A STRAIN 3415_V1_C1
Descriptor:ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN 3415_V1_C1, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSR
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-CH31 IN COMPLEX WITH HIV-1 CLADE A/E STRAN 93TH057 GP120 WITH LOOP D AND LOOP V5 FROM CLADE A STRAIN KER_2018_11
Descriptor:ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN ker_2018_11, HEAVY CHAIN OF ANTIBODY VRC-CH31, LIGHT CHAIN OF ANTIBODY VRC-CH31 (N70D MUTATION), ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSS
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV-1 CLADE A STRAIN KER_2018_11 GP120
Descriptor:envelope glycoprotein GP120, HEAVY CHAIN OF ANTIBODY VRC01, LIGHT CHAIN OF ANTIBODY VRC01 with N72T mutation, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LST
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC01 IN COMPLEX WITH HIV-1 CLADE C STRAIN ZM176.66 GP120
Descriptor:ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, HEAVY CHAIN OF ANTIBODY VRC01, LIGHT CHAIN OF ANTIBODY VRC01, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSU
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-PG20 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120
Descriptor:HIV-1 CLADE A/E STRAIN 93TH057 GP120, HEAVY CHAIN OF ANTIBODY VRC-PG20, LIGHT CHAIN OF ANTIBODY VRC-PG20, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSV
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 3BNC117 IN COMPLEX WITH HIV-1 CLADE C C1086 GP120
Descriptor:envelope glycoprotein GP120, HEAVY CHAIN OF ANTIBODY 3BNC117, LIGHT CHAIN OF ANTIBODY 3BNC117, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
5CD3
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STRUCTURE OF IMMATURE VRC01-CLASS ANTIBODY DRVIA7
Descriptor:DRVIA7 Heavy Chain, DRVIA7 Light Chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-02
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5CD5
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CRYSTAL STRUCTURE OF AN IMMATURE VRC01-CLASS ANTIBODY DRVIA7 FROM A CHINESE DONOR BOUND TO CLADE A/E HIV-1 GP120 CORE
Descriptor:93TH057 HIV-1 gp120 core, DRVIA7 Fab Heavy Chain, DRVIA7 Fab Light Chain, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-03
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5WXG
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STRUCTURE OF TAF PHD FINGER DOMAIN BINDS TO H3(1-15)K4AC
Descriptor:Transcription initiation factor TFIID subunit 3, Histone H3K4ac, ZINC ION, ...
Authors:Zhao, S., Li, H.
Deposit date:2017-01-07
Release date:2017-08-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017