Author results

3K3N
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CRYSTAL STRUCTURE OF THE CATALYTIC CORE DOMAIN OF HUMAN PHF8
分子名称:PHD finger protein 8, FE (II) ION
著者Yu, L., Wang, Y., Huang, S., Wang, J., Deng, Z., Wu, W., Gong, W., Chen, Z.
登録日2009-10-03
公開日2010-01-19
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights into a novel histone demethylase PHF8
Cell Res., 20, 2010
3K3O
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CRYSTAL STRUCTURE OF THE CATALYTIC CORE DOMAIN OF HUMAN PHF8 COMPLEXED WITH ALPHA-KETOGLUTARATE
分子名称:PHD finger protein 8, 2-OXOGLUTARIC ACID, FE (II) ION
著者Yu, L., Wang, Y., Huang, S., Wang, J., Deng, Z., Wu, W., Gong, W., Chen, Z.
登録日2009-10-03
公開日2010-01-19
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural insights into a novel histone demethylase PHF8
Cell Res., 20, 2010
4IFT
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CRYSTAL STRUCTURE OF DOUBLE MUTANT THERMOSTABLE NPPASE FROM GEOBACILLUS STEAROTHERMOPHILUS
分子名称:Thermostable NPPase
著者Guo, Z., Huang, J., Wang, F., Qiu, R., Wang, Y., Ji, C.
登録日2012-12-15
公開日2013-12-18
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.995 Å)
主引用文献Crystal structure of thermostable NPPase from Geobacillus stearothermophilus
To be Published
4IG4
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CRYSTAL STRUCTURE OF SINGLE MUTANT THERMOSTABLE NPPASE (N86S) FROM GEOBACILLUS STEAROTHERMOPHILUS
分子名称:Thermostable NPPase
著者Guo, Z., Wang, F., Huang, J., Qiu, R., Yang, Z., Wang, Y., Gong, W., Ji, C.
登録日2012-12-16
公開日2013-12-18
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.402 Å)
主引用文献Crystal structure of thermostable NPPase from Geobacillus stearothermophilus
To be Published
4MGR
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THE CRYSTAL STRUCTURE OF BACILLUS SUBTILIS GABR, AN AUTOREPRESSOR AND PLP- AND GABA-DEPENDENT TRANSCRIPTIONAL ACTIVATOR OF GABT
分子名称:HTH-type transcriptional regulatory protein GabR, ZINC ION, IMIDAZOLE, ...
著者Wu, R., Edayathumangalam, R., Garcia, R., Wang, Y., Wang, W., Kreinbring, C.A., Bach, A., Liao, J., Stone, T., Terwilliger, T., Hoang, Q.Q., Belitsky, B.R., Petsko, G.A., Ringe, D., Liu, D.
登録日2013-08-28
公開日2013-10-30
最終更新日2014-02-05
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.
Proc.Natl.Acad.Sci.USA, 110, 2013
4N0B
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CRYSTAL STRUCTURE OF BACILLUS SUBTILIS GABR, AN AUTOREPRESSOR AND TRANSCRIPTIONAL ACTIVATOR OF GABT
分子名称:HTH-type transcriptional regulatory protein GabR, ACETYL GROUP, ZINC ION, ...
著者Edayathumangalam, R., Wu, R., Garcia, R., Wang, Y., Wang, W., Kreinbring, C.A., Bach, A., Liao, J., Stone, T., Terwilliger, T., Hoang, Q.Q., Belitsky, B.R., Petsko, G.A., Ringe, D., Liu, D.
登録日2013-10-01
公開日2013-10-30
最終更新日2014-04-02
実験手法X-RAY DIFFRACTION (2.705 Å)
主引用文献Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.
Proc.Natl.Acad.Sci.USA, 110, 2013
4N77
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CRYSTAL STRUCTURE OF CAS PROTEIN
分子名称:Uncharacterized protein
著者Tian, W., Sheng, G., Zhao, H., Wang, J., Wang, Y.
登録日2013-10-15
公開日2014-10-15
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Crystal strucute studies of CasD
To be Published
4RL1
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF A LOADING ACYLTRANSFERASE FROM THE AVERMECTIN MODULAR POLYKETIDE SYNTHASE
分子名称:Type I polyketide synthase AVES 1
著者Wang, F., Wang, Y., Zheng, J.
登録日2014-10-15
公開日2015-01-28
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase.
Acs Chem.Biol., 10, 2015
4WGI
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A SINGLE DIASTEREOMER OF A MACROLACTAM CORE BINDS SPECIFICALLY TO MYELOID CELL LEUKEMIA 1 (MCL1)
分子名称:Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, MALTOSE, (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, ...
著者Clifton, M.C., Fairman, J.W., Fang, C., D'Souza, B., Fulroth, B., Leed, A., McCarren, P., Wang, L., Wang, Y., Kaushik, V., Palmer, M., Wei, G., Golub, T.R., Hubbard, B.K., Serrano-Wu, M.H.
登録日2014-09-18
公開日2014-11-19
最終更新日2014-12-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).
Acs Med.Chem.Lett., 5, 2014
4WHF
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CRYSTAL STRUCTURE OF TR3 LBD IN COMPLEX WITH 1-(3,4,5-TRIHYDROXYPHENYL)DECAN-1-ONE
分子名称:Nuclear receptor subfamily 4 group A member 1, GLYCEROL, 1-(3,4,5-trihydroxyphenyl)decan-1-one
著者Li, F.W., Cai, Q.X., Li, A.Z., Tian, X.Y., Wang, W.J., Wang, Y., Hou, P.P., Wu, Q., Lin, T.W.
登録日2014-09-22
公開日2015-09-09
最終更新日2015-10-14
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity
Chem.Biol., 22, 2015
4WHG
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CRYSTAL STRUCTURE OF TR3 LBD IN COMPLEX WITH MOLECULE 3
分子名称:Nuclear receptor subfamily 4 group A member 1, GLYCEROL, 1-(3,4,5-trihydroxyphenyl)octan-1-one
著者Li, F.W., Cai, Q.X., Li, A.Z., Tian, X.Y., Wang, W.J., Wang, Y., Hou, P.P., Wu, Q., Lin, T.W.
登録日2014-09-22
公開日2015-09-09
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity
Chem.Biol., 22, 2015
4XKL
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CRYSTAL STRUCTURE OF NDP52 ZF2 IN COMPLEX WITH MONO-UBIQUITIN
分子名称:Ubiquitin, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL, ...
著者Xie, X., Li, F., Wang, Y., Lin, Z., Chen, X., Liu, J., Pan, L.
登録日2015-01-12
公開日2015-11-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2
Autophagy, 11, 2015
5FBJ
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COMPLEX STRUCTURE OF JMJD5 AND SUBSTRATE
分子名称:Lysine-specific demethylase 8, 2-OXOGLUTARIC ACID, (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, ...
著者Liu, H.L., Wang, Y., Wang, C., Zhang, G.Y.
登録日2015-12-14
公開日2016-12-14
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献to be published
To Be Published
5UY8
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CRYSTAL STRUCTURE OF AICARFT BOUND TO AN ANTIFOLATE
分子名称:Bifunctional purine biosynthesis protein PURH, 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ...
著者Wang, J., Wang, Y., Fales, K.R., Atwell, S., Clawson, D.
登録日2017-02-23
公開日2018-01-10
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J. Med. Chem., 60, 2017
5UZ0
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CRYSTAL STRUCTURE OF AICARFT BOUND TO AN ANTIFOLATE
分子名称:Bifunctional purine biosynthesis protein PURH, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, MAGNESIUM ION, ...
著者Atwell, S., Wang, Y., Fales, K.R., Clawson, D., Wang, J.
登録日2017-02-24
公開日2018-01-10
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J. Med. Chem., 60, 2017
5V9U
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-1620 COVALENTLY BOUND TO K-RAS G12C
分子名称:GTPase KRas, CALCIUM ION, (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, ...
著者Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.
登録日2017-03-23
公開日2018-02-07
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
5WTJ
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CRYSTAL STRUCTURE OF AN ENDONUCLEASE
分子名称:CRISPR-associated endoribonuclease C2c2
著者Liu, L., Wang, Y.
登録日2016-12-13
公開日2017-02-08
最終更新日2017-08-30
実験手法X-RAY DIFFRACTION (3.503 Å)
主引用文献Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
Cell, 168, 2017
5WTK
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CRYSTAL STRUCTURE OF RNP COMPLEX
分子名称:CRISPR-associated endoribonuclease C2c2, RNA (58-MER)
著者Liu, L., Wang, Y.
登録日2016-12-13
公開日2017-02-08
実験手法X-RAY DIFFRACTION (2.651 Å)
主引用文献Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
Cell, 168, 2017
5XOU
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 7T8 ON THE GUIDE STRAND
分子名称:TtAgo (D546N), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*TP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Wang, J., Zhao, H., Wang, Y.
登録日2017-05-31
公開日2017-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
5XOW
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 6'A7' ON THE TARGET STRAND
分子名称:TtAgo (D546N), DNA (5'-D(P*(TD)P*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), RNA (5'-R(P*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*AP*CP*CP*UP*CP*G)-3'), ...
著者Sheng, G., Wang, J., Zhao, H., Wang, Y.
登録日2017-05-31
公開日2017-10-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.902 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
5XP8
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 4A5 ON THE GUIDE STRAND
分子名称:TtAgo, DNA (5'-D(P*TP*GP*AP*GP*AP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*CP*AP*AP*CP*C*AP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, J.D., Wang, Y.
登録日2017-06-01
公開日2018-04-18
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
5XPA
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 9'U10' ON THE TARGET STRAND
分子名称:Uncharacterized protein Ago, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), RNA (5'-R(P*AP*UP*AP*CP*AP*AP*CP*CP*GP*UP*UP*CP*UP*AP*CP*UP*CP*CP*G)-3'), ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, J.D., Wang, Y.
登録日2017-06-01
公開日2018-04-18
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
5XPG
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 6'U7' ON THE TARGET STRAND
分子名称:Uncharacterized protein, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*A P*GP*T)-3', 5'-R(*UP*AP*U*AP*CP*AP*AP*CP*CP*UP*AP*CP*AP*UP*AP*CP*CP*UP*CP* G)-3', ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, J.D., Wang, Y.
登録日2017-06-02
公開日2018-04-18
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
5XQ2
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CRYSTAL STRUCTURE OF T. THERMOPHILUS ARGONAUTE PROTEIN COMPLEXED WITH A BULGE 5A6 ON THE GUIDE STRAND
分子名称:TtAgo (D546N), DNA (5'-D(P*TP*GP*AP*AP*GP*AP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, D., Wang, Y.
登録日2017-06-06
公開日2017-10-04
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
5XWP
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CRYSTAL STRUCTURE OF LBUCAS13A-CRRNA-TARGET RNA TERNARY COMPLEX
分子名称:Uncharacterized protein, RNA (59-MER), RNA (30-MER)
著者Liu, L., Li, X., Li, Z., Wang, Y.
登録日2017-06-30
公開日2017-09-13
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.086 Å)
主引用文献The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a.
Cell, 170, 2017