Author results

4DH6
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STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH (2R)-N-((2S,3R)-1-(BENZO[D][1,3]DIOXOL-5-YL)-3-HYDROXY-4-((S)-6'-NEOPENTYL-3',4'-DIHYDROSPIRO[CYCLOBUTANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YLAMINO)BUTAN-2-YL)-2-METHOXYPROPANAMIDE
Descriptor:Beta-secretase 1, IODIDE ION, GLYCEROL, ...
Authors:Sickmier, E.A.
Deposit date:2012-01-27
Release date:2012-04-18
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design and preparation of a potent series of hydroxyethylamine containing beta-secretase inhibitors that demonstrate robust reduction of central beta-amyloid.
J.Med.Chem., 55, 2012
4DI2
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CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE INHIBITOR 37
Descriptor:Beta-secretase 1, (2R)-N-{(2S,3R)-4-{[(4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl]amino}-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl}-2-methoxypropanamide, GLYCEROL
Authors:Whittington, D.A., Long, A.M.
Deposit date:2012-01-30
Release date:2012-10-10
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and synthesis of potent, orally efficacious hydroxyethylamine derived beta-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J.Med.Chem., 55, 2012
4PPI
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CRYSTAL STRUCTURE OF BCL-XL HEXAMER
Descriptor:Bcl-2-like protein 1, GLYCEROL
Authors:Sreekanth, R., Yoon, H.S.
Deposit date:2014-02-27
Release date:2015-03-04
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.851 Å)
Cite:Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport
Sci Rep, 5, 2015
5HJB
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AF9 YEATS IN COMPLEX WITH HISTONE H3 CROTONYLATION AT K9
Descriptor:Protein AF-9, peptide of Histone H3.1
Authors:Li, Y.Y., Zhao, D., Guan, H.P., Li, H.T.
Deposit date:2016-01-12
Release date:2016-04-20
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Mol.Cell, 62, 2016
5HJC
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BRD3 SECOND BROMODOMAIN IN COMPLEX WITH HISTONE H3 ACETYLATION AT K18
Descriptor:Bromodomain-containing protein 3, peptide of Histone H3.1, 1,2-ETHANEDIOL, ...
Authors:Li, Y.Y., Zhao, D., Guan, H.P., Li, H.T.
Deposit date:2016-01-13
Release date:2016-04-20
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Mol.Cell, 62, 2016
5HJD
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AF9 YEATS IN COMPLEX WITH HISTONE H3 CROTONYLATION AT K18
Descriptor:Protein AF-9, peptide of Histone H3.1, COPPER (II) ION, ...
Authors:Li, Y.Y., Zhao, D., Guan, H.P., Li, H.T.
Deposit date:2016-01-13
Release date:2016-04-20
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.806 Å)
Cite:Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.
Mol.Cell, 62, 2016
5SZB
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STRUCTURE OF HUMAN DPF3 DOUBLE-PHD DOMAIN BOUND TO HISTONE H3 TAIL PEPTIDE WITH ACETYLATED K14
Descriptor:Zinc finger protein DPF3, Histone H3 tail peptide, ZINC ION, ...
Authors:Singh, N., Local, A., Shiau, A., Ren, B., Corbett, K.D.
Deposit date:2016-08-13
Release date:2017-08-16
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Identification of H3K4me1-associated proteins at mammalian enhancers.
Nat. Genet., 50, 2018
5SZC
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STRUCTURE OF HUMAN DPF3 DOUBLE-PHD DOMAIN BOUND TO HISTONE H3 TAIL PEPTIDE WITH MONOMETHYLATED K4 AND ACETYLATED K14
Descriptor:Zinc finger protein DPF3, Histone H3 tail peptide, ZINC ION, ...
Authors:Singh, N., Local, A., Shiau, A., Ren, B., Corbett, K.D.
Deposit date:2016-08-13
Release date:2017-08-16
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.193 Å)
Cite:Identification of H3K4me1-associated proteins at mammalian enhancers.
Nat. Genet., 50, 2018
5Z07
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CRYSTAL STRUCTURE OF CENTROMERE PROTEIN CENP-I
Descriptor:Cenp-I
Authors:Tian, W., Hu, L.Q., He, X.
Deposit date:2017-12-18
Release date:2018-10-31
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment.
Nucleic Acids Res., 47, 2019
5Z08
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THE CRYSTAL STRUCTURE OF KINETOCHORE SUBUNITS CENP-H/I/K TRIPLE COMPLEX
Descriptor:Cenp-I, Cenp-K, Cenp-H
Authors:Tian, W., Hu, L.Q., He, X.
Deposit date:2017-12-18
Release date:2018-10-31
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment.
Nucleic Acids Res., 47, 2019
6DRR
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CRYSTAL STRUCTURE OF CJ0485 DEHYDROGENASE
Descriptor:Short-chain dehydrogenase, 1,2-ETHANEDIOL
Authors:Pluvinage, B., Boraston, A.B.
Deposit date:2018-06-12
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:No longer asaccharolytic - L-fucose and D-arabinose metabolism in Campylobacter jejuni
To be published
6DS1
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CRYSTAL STRUCTURE OF CJ0485 DEHYDROGENASE IN COMPLEX WITH NADP+
Descriptor:Putative oxidoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ...
Authors:Pluvinage, B., Boraston, A.B.
Deposit date:2018-06-13
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.119 Å)
Cite:No longer asaccharolytic - L-fucose and D-arabinose metabolism in Campylobacter jejuni
To be published
6J8F
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CRYSTAL STRUCTURE OF SVBP-VASH1 WITH PEPTIDE MIMIC THE C-TERMINAL OF ALPHA-TUBULIN
Descriptor:Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1, 8-mer peptide
Authors:Liao, S., Gao, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2019-01-18
Release date:2019-06-19
Method:X-RAY DIFFRACTION (2.283 Å)
Cite:Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.
Cell Res., 2019
6J8N
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CRYSTAL STRUCTURE OF SVBP-VASH1 COMPLEX, MUTATION C169A OF VASH1
Descriptor:Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1
Authors:Liao, S., Gao, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2019-01-20
Release date:2019-06-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.
Cell Res., 2019
6J91
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STRUCTURE OF A HYPOTHETICAL PROTEASE
Descriptor:Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1
Authors:Liao, S., Gao, J., Xu, C.
Deposit date:2019-01-21
Release date:2019-06-19
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.
Cell Res., 2019
6J9H
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CRYSTAL STRUCTURE OF SVBP-VASH1 COMPLEX
Descriptor:Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1
Authors:Liao, S., Gao, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2019-01-22
Release date:2019-06-19
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.
Cell Res., 2019
6QBY
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CRYSTAL STRUCTURE OF VASH 2 IN COMPLEX WITH SVBP
Descriptor:Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein
Authors:Choi, S.R., Olieric, V., Steinmetz, M.O., Olieric, N.
Deposit date:2018-12-24
Release date:2019-04-24
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Nat.Struct.Mol.Biol., 2019
2CMG
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CRYSTAL STRUCTURE OF SPERMIDINE SYNTHASE FROM HELICOBACTER PYLORI
Descriptor:SPERMIDINE SYNTHASE
Authors:sun, y.-j., lu, p.-k.
Deposit date:2006-05-08
Release date:2007-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Helicobacter Pylori Spermidine Synthase: A Rossmann-Like Fold with a Distinct Active Site
Proteins: Struct., Funct., Bioinf., 67, 2007
2CMH
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CRYSTAL STRUCTURE OF SPERMIDINE SYNTHASE FROM HELICOBACTER PYLORI
Descriptor:SPERMIDINE SYNTHASE
Authors:Sun, Y.-J., Lu, P.-K.
Deposit date:2006-05-08
Release date:2007-05-08
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Helicobacter Pylori Spermidine Synthase: A Rossmann-Like Fold with a Distinct Active Site
Proteins: Struct., Funct., Bioinf., 67, 2007
2JR7
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SOLUTION STRUCTURE OF HUMAN DESR1
Descriptor:DPH3 homolog, ZINC ION
Authors:Wu, F., Wu, J., Shi, Y.
Deposit date:2007-06-21
Release date:2008-03-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human DESR1, a CSL zinc-binding protein
Proteins, 71, 2008
2KV8
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SOLUTION STRUCTURE OFRGS12 PDZ DOMAIN
Descriptor:Regulator of G-protein signaling 12
Authors:Lu, G., Ji, P., Huang, H.
Deposit date:2010-03-10
Release date:2011-03-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Determining the Molecular Basis for the pH-dependent Interaction between the PDZ of Human RGS12 and MEK2
To be Published
2L26
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RV0899 FROM MYCOBACTERIUM TUBERCULOSIS CONTAINS TWO SEPARATED DOMAINS
Descriptor:Uncharacterized protein Rv0899/MT0922
Authors:Shi, C., Li, J., Gao, Y., Wu, K., Huang, H., Tian, C.
Deposit date:2010-08-12
Release date:2011-08-17
Last modified:2011-12-07
Method:SOLUTION NMR
Cite:Structural Studies of Mycobacterium tuberculosis Rv0899 Reveal a Monomeric Membrane-Anchoring Protein with Two Separate Domains
J.Mol.Biol., 2011
2VW9
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SINGLE STRANDED DNA BINDING PROTEIN COMPLEX FROM HELICOBACTER PYLORI
Descriptor:SINGLE-STRANDED DNA BINDING PROTEIN, POLY-DT
Authors:Chan, K.-W., Wang, C.-H., Lee, Y.-J., Sun, Y.-J.
Deposit date:2008-06-18
Release date:2009-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Single-Stranded DNA-Binding Protein Complex from Helicobacter Pylori Suggests an Ssdna-Binding Surface.
J.Mol.Biol., 388, 2009
3H15
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CRYSTAL STRUCTURE OF REPLICATION INITIATION FACTOR MCM10-ID BOUND TO SSDNA
Descriptor:Protein MCM10 homolog, 5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*C)-3', ZINC ION
Authors:Warren, E.M., Eichman, B.F.
Deposit date:2009-04-10
Release date:2009-07-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Physical Interactions between Mcm10, DNA, and DNA Polymerase {alpha}.
J.Biol.Chem., 284, 2009
3MMZ
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CRYSTAL STRUCTURE OF PUTATIVE HAD FAMILY HYDROLASE FROM STREPTOMYCES AVERMITILIS MA-4680
Descriptor:putative HAD family hydrolase, CALCIUM ION, CHLORIDE ION
Authors:Malashkevich, V.N., Ramagopal, U.A., Toro, R., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2010-04-20
Release date:2010-04-28
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis.
Biochemistry, 52, 2013