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4D3O
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-(3-(2-(1H-PYRROLO(2,3-B)PYRIDIN-6-YL)ETHYL)-5-(AMINOMETHYL) PHENETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3T
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH N-{3-[(1S)-2-(3-{(Z)-[AMINO(THIOPHEN-2-YL)METHYLIDENE]AMINO}PHENOXY)-1-HYDROXYETHYL]PHENYL}THIOPHENE-2-CARBOXIMIDAMIDE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3U
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE H128S IN COMPLEX WITH N-{3-[(1S)-2-(3-{(Z)-[AMINO(THIOPHEN-2-YL)METHYLIDENE]AMINO}PHENOXY)-1-HYDROXYETHYL]PHENYL}THIOPHENE-2-CARBOXIMIDAMIDE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.981 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3V
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE I218V IN COMPLEX WITH N-{3-[(1S)-2-(3-{(Z)-[AMINO(THIOPHEN-2-YL)METHYLIDENE]AMINO}PHENOXY)-1-HYDROXYETHYL]PHENYL}THIOPHENE-2-CARBOXIMIDAMIDE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4DH6
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STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH (2R)-N-((2S,3R)-1-(BENZO[D][1,3]DIOXOL-5-YL)-3-HYDROXY-4-((S)-6'-NEOPENTYL-3',4'-DIHYDROSPIRO[CYCLOBUTANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YLAMINO)BUTAN-2-YL)-2-METHOXYPROPANAMIDE
Descriptor:Beta-secretase 1, IODIDE ION, GLYCEROL, ...
Authors:Sickmier, E.A.
Deposit date:2012-01-27
Release date:2012-04-18
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design and preparation of a potent series of hydroxyethylamine containing beta-secretase inhibitors that demonstrate robust reduction of central beta-amyloid.
J.Med.Chem., 55, 2012
4DI2
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CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH HYDROXYETHYLAMINE INHIBITOR 37
Descriptor:Beta-secretase 1, (2R)-N-{(2S,3R)-4-{[(4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl]amino}-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl}-2-methoxypropanamide, GLYCEROL
Authors:Whittington, D.A., Long, A.M.
Deposit date:2012-01-30
Release date:2012-10-10
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and synthesis of potent, orally efficacious hydroxyethylamine derived beta-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J.Med.Chem., 55, 2012
4PPI
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CRYSTAL STRUCTURE OF BCL-XL HEXAMER
Descriptor:Bcl-2-like protein 1, GLYCEROL
Authors:Sreekanth, R., Yoon, H.S.
Deposit date:2014-02-27
Release date:2015-03-04
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.851 Å)
Cite:Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport
Sci Rep, 5, 2015
5HJB
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AF9 YEATS IN COMPLEX WITH HISTONE H3 CROTONYLATION AT K9
Descriptor:Protein AF-9, peptide of Histone H3.1
Authors:Li, Y.Y., Zhao, D., Guan, H.P., Li, H.T.
Deposit date:2016-01-12
Release date:2016-04-20
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Mol.Cell, 62, 2016
5HJC
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BRD3 SECOND BROMODOMAIN IN COMPLEX WITH HISTONE H3 ACETYLATION AT K18
Descriptor:Bromodomain-containing protein 3, peptide of Histone H3.1, 1,2-ETHANEDIOL, ...
Authors:Li, Y.Y., Zhao, D., Guan, H.P., Li, H.T.
Deposit date:2016-01-13
Release date:2016-04-20
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Mol.Cell, 62, 2016
5HJD
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AF9 YEATS IN COMPLEX WITH HISTONE H3 CROTONYLATION AT K18
Descriptor:Protein AF-9, peptide of Histone H3.1, COPPER (II) ION, ...
Authors:Li, Y.Y., Zhao, D., Guan, H.P., Li, H.T.
Deposit date:2016-01-13
Release date:2016-04-20
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.806 Å)
Cite:Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.
Mol.Cell, 62, 2016
5SZB
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STRUCTURE OF HUMAN DPF3 DOUBLE-PHD DOMAIN BOUND TO HISTONE H3 TAIL PEPTIDE WITH ACETYLATED K14
Descriptor:Zinc finger protein DPF3, Histone H3 tail peptide, ZINC ION, ...
Authors:Singh, N., Local, A., Shiau, A., Ren, B., Corbett, K.D.
Deposit date:2016-08-13
Release date:2017-08-16
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Identification of H3K4me1-associated proteins at mammalian enhancers.
Nat. Genet., 50, 2018
5SZC
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STRUCTURE OF HUMAN DPF3 DOUBLE-PHD DOMAIN BOUND TO HISTONE H3 TAIL PEPTIDE WITH MONOMETHYLATED K4 AND ACETYLATED K14
Descriptor:Zinc finger protein DPF3, Histone H3 tail peptide, ZINC ION, ...
Authors:Singh, N., Local, A., Shiau, A., Ren, B., Corbett, K.D.
Deposit date:2016-08-13
Release date:2017-08-16
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.193 Å)
Cite:Identification of H3K4me1-associated proteins at mammalian enhancers.
Nat. Genet., 50, 2018
5Z07
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CRYSTAL STRUCTURE OF CENTROMERE PROTEIN CENP-I
Descriptor:Cenp-I
Authors:Tian, W., Hu, L.Q., He, X.
Deposit date:2017-12-18
Release date:2018-10-31
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment.
Nucleic Acids Res., 47, 2019
5Z08
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THE CRYSTAL STRUCTURE OF KINETOCHORE SUBUNITS CENP-H/I/K TRIPLE COMPLEX
Descriptor:Cenp-I, Cenp-K, Cenp-H
Authors:Tian, W., Hu, L.Q., He, X.
Deposit date:2017-12-18
Release date:2018-10-31
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment.
Nucleic Acids Res., 47, 2019
6DRR
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CRYSTAL STRUCTURE OF CJ0485 DEHYDROGENASE
Descriptor:Short-chain dehydrogenase, 1,2-ETHANEDIOL
Authors:Pluvinage, B., Boraston, A.B.
Deposit date:2018-06-12
Release date:2019-07-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:The gastrointestinal pathogen Campylobacter jejuni metabolizes sugars with potential help from commensal Bacteroides vulgatus.
Commun Biol, 3, 2020
6DS1
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CRYSTAL STRUCTURE OF CJ0485 DEHYDROGENASE IN COMPLEX WITH NADP+
Descriptor:Putative oxidoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ...
Authors:Pluvinage, B., Boraston, A.B.
Deposit date:2018-06-13
Release date:2019-07-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.119 Å)
Cite:The gastrointestinal pathogen Campylobacter jejuni metabolizes sugars with potential help from commensal Bacteroides vulgatus.
Commun Biol, 3, 2020
6J7N
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CRYSTAL STRUCTURE OF TOXIN TGLT (UNUSUAL TYPE GUANYLYLTRANSFERASE-LIKE TOXIN, RV1045) MUTANT D82A CO-EXPRESSED WITH TAKA FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:guanylyltransferase-like toxin, MAGNESIUM ION
Authors:Yu, X., Gao, X., Zhu, K., Wojdyla, J.A., Wang, M., Cui, S.
Deposit date:2019-01-18
Release date:2020-05-13
Last modified:2020-05-20
Method:X-RAY DIFFRACTION (2.294 Å)
Cite:Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
6J7O
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CRYSTAL STRUCTURE OF TOXIN TGLT (UNUSUAL TYPE GUANYLYLTRANSFERASE-LIKE TOXIN, RV1045) MUTANT E146Q FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:guanylyltransferase-like toxin, MAGNESIUM ION
Authors:Yu, X., Gao, X., Zhu, K., Wojdyla, J.A., Wang, M., Cui, S.
Deposit date:2019-01-18
Release date:2020-05-13
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
6J7P
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CRYSTAL STRUCTURE OF TOXIN TGLT (UNUSUAL TYPE GUANYLYLTRANSFERASE-LIKE TOXIN, RV1045) MUTANT E146Q CO-EXPRESSED WITH TAKA FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:guanylyltransferase-like toxin, MAGNESIUM ION
Authors:Yu, X., Gao, X., Zhu, K., Wojdyla, J.A., Wang, M., Cui, S.
Deposit date:2019-01-18
Release date:2020-05-13
Last modified:2020-05-20
Method:X-RAY DIFFRACTION (2.629 Å)
Cite:Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
6J7Q
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CRYSTAL STRUCTURE OF TOXIN TGLT (UNUSUAL TYPE GUANYLYLTRANSFERASE-LIKE TOXIN, RV1045) MUTANT S78A FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:guanylyltransferase-like toxin, MAGNESIUM ION, CALCIUM ION
Authors:Yu, X., Gao, X., Zhu, K., Wojdyla, J.A., Wang, M., Cui, S.
Deposit date:2019-01-18
Release date:2020-05-13
Last modified:2020-05-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
6J7R
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CRYSTAL STRUCTURE OF TOXIN TGLT (UNUSUAL TYPE GUANYLYLTRANSFERASE-LIKE TOXIN, RV1045) MUTANT S78A CO-EXPRESSED WITH TAKA FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:guanylyltransferase-like toxin, MAGNESIUM ION
Authors:Yu, X., Gao, X., Zhu, K., Wojdyla, J.A., Wang, M., Cui, S.
Deposit date:2019-01-18
Release date:2020-05-13
Last modified:2020-05-20
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
6J7S
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CRYSTAL STRUCTURE OF TOXIN TGLT (UNUSUAL TYPE GUANYLYLTRANSFERASE-LIKE TOXIN, RV1045) WILD TYPE PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:guanylyltransferase-like toxin, MAGNESIUM ION
Authors:Yu, X., Gao, X., Zhu, K., Wojdyla, J.A., Wang, M., Cui, S.
Deposit date:2019-01-18
Release date:2020-05-13
Last modified:2020-05-20
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
6J7T
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CRYSTAL STRUCTURE OF TOXIN TGLT (UNUSUAL TYPE GUANYLYLTRANSFERASE-LIKE TOXIN, RV1045) MUTANT D82A FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:guanylyltransferase-like toxin, MAGNESIUM ION, GLYCEROL
Authors:Yu, X., Gao, X., Zhu, K., Wojdyla, J.A., Wang, M., Cui, S.
Deposit date:2019-01-18
Release date:2020-05-13
Last modified:2020-05-20
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism.
Commun Biol, 3, 2020
6J8F
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CRYSTAL STRUCTURE OF SVBP-VASH1 WITH PEPTIDE MIMIC THE C-TERMINAL OF ALPHA-TUBULIN
Descriptor:Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1, 8-mer peptide
Authors:Liao, S., Gao, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2019-01-18
Release date:2019-06-19
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.283 Å)
Cite:Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.
Cell Res., 29, 2019
6J8N
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CRYSTAL STRUCTURE OF SVBP-VASH1 COMPLEX, MUTATION C169A OF VASH1
Descriptor:Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1
Authors:Liao, S., Gao, J., Xu, C., Structural Genomics Consortium (SGC)
Deposit date:2019-01-20
Release date:2019-06-19
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.
Cell Res., 29, 2019
167327
数据于2020-08-05公开中