Author results

5WP3
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CRYSTAL STRUCTURE OF EED IN COMPLEX WITH EB22
分子名称:Polycomb protein EED, EB22, UNKNOWN ATOM OR ION
著者Dong, C., Tempel, W., Zhu, L., Moody, J.D., Baker, D., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-08-03
公開日2017-09-13
最終更新日2017-12-06
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6BHD
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CRYSTAL STRUCTURE OF SETDB1 WITH A MODIFIED H3 PEPTIDE
分子名称:Histone-lysine N-methyltransferase SETDB1, Histone H3.1, UNKNOWN ATOM OR ION, ...
著者Qin, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-10-30
公開日2017-12-06
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6BHE
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CRYSTAL STRUCTURE OF SETDB1 WITH A MODIFIED H3 PEPTIDE
分子名称:Histone-lysine N-methyltransferase SETDB1, Histone H3.1, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-10-30
公開日2017-12-06
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6BHG
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CRYSTAL STRUCTURE OF SETDB1 WITH A MODIFIED H3 PEPTIDE
分子名称:Histone-lysine N-methyltransferase SETDB1, Histone H3.1, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-10-30
公開日2017-12-06
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6BHH
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CRYSTAL STRUCTURE OF SETDB1 WITH A MODIFIED H3 PEPTIDE
分子名称:Histone-lysine N-methyltransferase SETDB1, Histone H3.1, SULFATE ION, ...
著者Qin, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-10-30
公開日2017-11-22
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6BHI
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CRYSTAL STRUCTURE OF SETDB1 WITH A MODIFIED H3 PEPTIDE
分子名称:Histone-lysine N-methyltransferase SETDB1, Histone H3.1, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-10-30
公開日2017-12-06
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6C1A
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MBD2 IN COMPLEX WITH METHYLATED DNA
分子名称:Methyl-CpG-binding domain protein 2, dna strand 1, complement to dna strand 1, ...
著者Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-01-04
公開日2018-02-14
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1T
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MBD2 IN COMPLEX WITH A PARTIALLY METHYLATED DNA
分子名称:Methyl-CpG-binding domain protein 2, 12-mer DNA, SULFATE ION, ...
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-01-05
公開日2018-02-14
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1U
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MBD2 IN COMPLEX WITH A DEOXY-OLIGONUCLEOTIDE
分子名称:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-01-05
公開日2018-02-14
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1V
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MBD2 IN COMPLEX WITH DOUBLE-STRANDED DNA
分子名称:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
著者Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-01-05
公開日2018-02-14
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CC8
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CRYSTAL STRUCTURE MBD3 MBD DOMAIN IN COMPLEX WITH METHYLATED CPG DNA
分子名称:Methyl-CpG-binding domain protein 3, methylated CpG DNA, UNKNOWN ATOM OR ION
著者Liu, K., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-06
公開日2018-04-04
最終更新日2019-09-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
6CCG
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CRYSTAL STRUCTURE MBD3 MBD DOMAIN IN COMPLEX WITH METHYLATED CPG DNA
分子名称:Methyl-CpG-binding domain protein 3, DNA, UNKNOWN ATOM OR ION
著者Liu, K., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-07
公開日2018-05-09
最終更新日2019-09-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
6CEU
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MBD3 MBD IN COMPLEX WITH METHYLATED, NON-PALINDROMIC CPG DNA: ALTERNATIVE INTERPRETATION OF CRYSTALLOGRAPHIC DATA
分子名称:Methyl-CpG-binding domain protein 3, DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), ...
著者Liu, K., Tempel, W., Wernimont, A.K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-12
公開日2018-05-09
最終更新日2019-09-04
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
6CEV
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MBD3 MBD IN COMPLEX WITH METHYLATED, NON-PALINDROMIC CPG DNA: ALTERNATIVE INTERPRETATION OF CRYSTALLOGRAPHIC DATA
分子名称:Methyl-CpG-binding domain protein 3, DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), ...
著者Liu, K., Tempel, W., Wernimont, A.K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-12
公開日2018-05-09
最終更新日2019-09-04
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
6CKN
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CRYSTAL STRUCTURE OF AN AF10 FRAGMENT
分子名称:Protein AF-10, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-28
公開日2018-03-21
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Genes Dev., 32, 2018
6CKO
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CRYSTAL STRUCTURE OF AN AF10 FRAGMENT
分子名称:Protein AF-10, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ...
著者Zhang, H., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-02-28
公開日2018-03-21
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Genes Dev., 32, 2018
6CNP
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CRYSTAL STRUCTURE OF MBD2 COMPLEX WITH METHYLATED CPG ISLAND
分子名称:Methyl-CpG-binding domain protein 2, DNA (5'-D(*GP*CP*CP*AP*CP*(5CM)P*GP*GP*TP*GP*GP*C)-3'), CALCIUM ION, ...
著者Xu, C., Min, J., Structural Genomics Consortium (SGC)
登録日2018-03-08
公開日2018-03-28
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CNQ
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MBD2 IN COMPLEX WITH METHYLATED DNA
分子名称:Methyl-CpG-binding domain protein 2, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), UNKNOWN ATOM OR ION
著者Liu, K., Xu, C., Min, J., Structural Genomics Consortium (SGC)
登録日2018-03-08
公開日2018-03-28
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (2.151 Å)
主引用文献Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
2L11
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SOLUTION NMR STRUCTURE OF THE CBX3 IN COMPLEX WITH H3K9ME3 PEPTIDE
分子名称:Chromobox protein homolog 3, Histone H3
著者Kaustov, L., Lemak, A., Fares, C., Gutmanas, A., Quang, H., Loppnau, P., Min, J., Edwards, A., Arrowsmith, C., Structural Genomics Consortium (SGC)
登録日2010-07-22
公開日2010-08-04
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Recognition and specificity determinants of the human cbx chromodomains.
J.Biol.Chem., 286, 2011
2L12
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SOLUTION NMR STRUCTURE OF THE CHROMOBOX PROTEIN 7 WITH H3K9ME3
分子名称:Chromobox homolog 7, Histone H3
著者Kaustov, L., Lemak, A., Gutmanas, A., Fares, C., Quang, H., Loppnau, P., Min, J., Edwards, A., Arrowsmith, C., Structural Genomics Consortium (SGC)
登録日2010-07-22
公開日2010-08-04
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Recognition and specificity determinants of the human cbx chromodomains.
J.Biol.Chem., 286, 2011
2L1B
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SOLUTION NMR STRUCTURE OF THE CHROMOBOX PROTEIN CBX7 WITH H3K27ME3
分子名称:Chromobox protein homolog 7, Histone H3
著者Kaustov, L., Lemak, A., Fares, C., Gutmanas, A., Muhandiram, R., Quang, H., Loppnau, P., Min, J., Edwards, A., Arrowsmith, C., Structural Genomics Consortium (SGC)
登録日2010-07-27
公開日2010-08-25
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Recognition and specificity determinants of the human cbx chromodomains.
J.Biol.Chem., 286, 2011
2LLK
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SOLUTION NMR STRUCTURE OF THE N-TERMINAL MYB-LIKE 1 DOMAIN OF THE HUMAN CYCLIN-D-BINDING TRANSCRIPTION FACTOR 1 (HDMP1), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET ID HR8011A
分子名称:Cyclin-D-binding Myb-like transcription factor 1
著者Montecchio, M., Lemak, A., Yee, A., Xu, C., Garcia, M., Houliston, S., Min, J., Bellanda, M., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
登録日2011-11-10
公開日2011-11-23
実験手法SOLUTION NMR
主引用文献Solution NMR structure of the N-terminal myb-like 1 domain of the human cyclin D binding transcription factor 1 (hDMP1).
To be Published
2LLL
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SOLUTION NMR STRUCTURE OF C-TERMINAL GLOBULAR DOMAIN OF HUMAN LAMIN-B2, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR8546A
分子名称:Lamin-B2
著者Lemak, A., Yee, A., Houliston, S., Garcia, M., Xu, C., Min, J., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC), Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS)
登録日2011-11-11
公開日2011-12-07
最終更新日2011-12-14
実験手法SOLUTION NMR
主引用文献NMR solution structure of c-terminal globular domain of human Lamin-B2
To be Published
2LTP
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SOLUTION STRUCTURE OF THE SANT2 DOMAIN OF THE HUMAN NUCLEAR RECEPTOR COREPRESSOR 2 (NCOR2), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET ID HR4636E
分子名称:Nuclear receptor corepressor 2
著者Montecchio, M., Lemak, A., Yee, A., Xu, C., Garcia, M., Houliston, S., Bellanda, M., Min, J., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC)
登録日2012-05-30
公開日2012-06-20
実験手法SOLUTION NMR
主引用文献Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2).
To be Published
2LV9
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SOLUTION NMR STRUCTURE OF THE PHD DOMAIN OF HUMAN MLL5, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR6512A
分子名称:Histone-lysine N-methyltransferase MLL5, ZINC ION
著者Lemak, A., Yee, A., Houliston, S., Garcia, M., Wu, H., Min, J., Montelione, G.T., Arrowsmith, C., Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC), Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS)
登録日2012-06-29
公開日2012-09-05
最終更新日2012-11-28
実験手法SOLUTION NMR
主引用文献NMR solution structure of the human MLL5 PHD domain (CASP Target)
To be Published