Author results

4S03
  • Download 4s03
  • View 4s03
Molmil generated image of 4s03
BIPHENYLALANINE MODIFIED THREONYL-TRNA SYNTHETASE FROM PYROCOCCUS ABYSSI: I11BIF, Y79I, AND F123A MUTANT
Descriptor:Threonine--tRNA ligase
Authors:Pearson, A.D., Mills, J.H., Song, Y., Nasertorabi, F., Han, G.W., Baker, D., Stevens, R.C., Schultz, P.G.
Deposit date:2014-12-30
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Transition states. Trapping a transition state in a computationally designed protein bottle.
Science, 347, 2015
4S0I
  • Download 4s0i
  • View 4s0i
Molmil generated image of 4s0i
BIPHENYLALANINE MODIFIED THREONYL-TRNA SYNTHETASE FROM PYROCOCCUS ABYSSI: 11BIF, 42F, 79S, AND 123A MUTANT
Descriptor:Threonine--tRNA ligase
Authors:Pearson, A.D., Mills, J.H., Song, Y., Nasertorabi, F., Han, G.W., Baker, D., Stevens, R.C., Schultz, P.G.
Deposit date:2014-12-31
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Transition states. Trapping a transition state in a computationally designed protein bottle.
Science, 347, 2015
4S0J
  • Download 4s0j
  • View 4s0j
Molmil generated image of 4s0j
BIPHENYLALANINE MODIFIED THREONYL-TRNA SYNTHETASE FROM PYROCOCCUS ABYSSI: 11BIF, 42F, 79S, AND 123V MUTANT
Descriptor:Threonine--tRNA ligase
Authors:Pearson, A.D., Mills, J.H., Song, Y., Nasertorabi, F., Han, G.W., Baker, D., Stevens, R.C., Schultz, P.G.
Deposit date:2014-12-31
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Transition states. Trapping a transition state in a computationally designed protein bottle.
Science, 347, 2015
4S0K
  • Download 4s0k
  • View 4s0k
Molmil generated image of 4s0k
BIPHENYLALANINE MODIFIED THREONYL-TRNA SYNTHETASE FROM PYROCOCCUS ABYSSI: 11BIF, 42F, 79V, AND 123A MUTANT
Descriptor:Threonine--tRNA ligase, DI(HYDROXYETHYL)ETHER
Authors:Pearson, A.D., Mills, J.H., Song, Y., Nasertorabi, F., Han, G.W., Baker, D., Stevens, R.C., Schultz, P.G.
Deposit date:2014-12-31
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Transition states. Trapping a transition state in a computationally designed protein bottle.
Science, 347, 2015
4S0L
  • Download 4s0l
  • View 4s0l
Molmil generated image of 4s0l
BIPHENYLALANINE MODIFIED THREONYL-TRNA SYNTHETASE FROM PYROCOCCUS ABYSSI: I11BIF, Y79V, AND F123V MUTANT
Descriptor:Threonine--tRNA ligase
Authors:Pearson, A.D., Mills, J.H., Song, Y., Nasertorabi, F., Han, G.W., Baker, D., Stevens, R.C., Schultz, P.G.
Deposit date:2014-12-31
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Transition states. Trapping a transition state in a computationally designed protein bottle.
Science, 347, 2015
4TQL
  • Download 4tql
  • View 4tql
Molmil generated image of 4tql
COMPUTATIONALLY DESIGNED THREE HELIX BUNDLE
Descriptor:Three helix bundle
Authors:Nannenga, B.L., Oberdorfer, G., DiMaio, F., Baker, D., Gonen, T.
Deposit date:2014-06-11
Release date:2014-10-15
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:High thermodynamic stability of parametrically designed helical bundles.
Science, 346, 2014
5A0E
  • Download 5a0e
  • View 5a0e
Molmil generated image of 5a0e
CRYSTAL STRUCTURE OF CYCLOPHILIN D IN COMPLEX WITH CSA ANALOGUE, JW47.
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL, JW47
Authors:Warne, J., Pryce, G., Hill, J., Shi, X., Lenneras, F., Puentes, F., Kip, M., Hilditch, L., Walker, P., Simone, M., Chan, A.W.E., Towers, G., Coker, A.R., Duchen, M., Szabadkai, G., Baker, D., Selwood, D.L.
Deposit date:2015-04-19
Release date:2015-12-30
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects Against Neuro-Degeneration in Experimental Multiple Sclerosis.
J.Biol.Chem., 291, 2016
5CW9
  • Download 5cw9
  • View 5cw9
Molmil generated image of 5cw9
CRYSTAL STRUCTURE OF DE NOVO DESIGNED FERREDOXIN-FERREDOXIN DOMAIN INSERTION PROTEIN
Descriptor:De novo designed ferredoxin-ferredoxin domain insertion protein
Authors:DiMaio, F., King, I.C., Gleixner, J., Doyle, L., Stoddard, B., Baker, D.
Deposit date:2015-07-28
Release date:2015-09-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.108 Å)
Cite:Precise assembly of complex beta sheet topologies from de novo designed building blocks.
Elife, 4, 2015
5EC0
  • Download 5ec0
  • View 5ec0
Molmil generated image of 5ec0
CRYSTAL STRUCTURE OF ACTIN-LIKE PROTEIN ALP7A
Descriptor:Alp7A, GLYCEROL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Petek, N.A., Kraemer, J.A., Mullins, R.D., Agard, D.A., DiMaio, F., Baker, D.
Deposit date:2015-10-20
Release date:2016-11-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and function of Alp7A reveal both conserved and unique features of plasmid segregation.
To Be Published
5EIL
  • Download 5eil
  • View 5eil
Molmil generated image of 5eil
COMPUTATIONAL DESIGN OF A HIGH-AFFINITY METALLOPROTEIN HOMOTRIMER CONTAINING A METAL CHELATING NON-CANONICAL AMINO ACID
Descriptor:TRI-05, FE (III) ION
Authors:Sankaran, B., Zwart, P.H., Mills, J.H., Pereira, J.H., Baker, D.
Deposit date:2015-10-30
Release date:2016-11-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Computational design of a homotrimeric metalloprotein with a trisbipyridyl core.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5IZS
  • Download 5izs
  • View 5izs
Molmil generated image of 5izs
DE NOVO DESIGN OF PROTEIN HOMO-OLIGOMERS WITH MODULAR HYDROGEN BOND NETWORK-MEDIATED SPECIFICITY
Descriptor:Designed protein 5L6HC3_1
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Boyken, S., Chen, Z., Oberdorfer, G.
Deposit date:2016-03-25
Release date:2016-05-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5J0H
  • Download 5j0h
  • View 5j0h
Molmil generated image of 5j0h
DE NOVO DESIGN OF PROTEIN HOMO-OLIGOMERS WITH MODULAR HYDROGEN BOND NETWORK-MEDIATED SPECIFICITY
Descriptor:Design construct 2L6HC3_13
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Boyken, S., Chen, Z., Groves, B., Langan, R.A., Oberdorfer, G., Ford, A., Gilmore, J., Xu, C., DiMaio, F., Seelig, G.
Deposit date:2016-03-28
Release date:2016-05-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5J0I
  • Download 5j0i
  • View 5j0i
Molmil generated image of 5j0i
DE NOVO DESIGN OF PROTEIN HOMO-OLIGOMERS WITH MODULAR HYDROGEN BOND NETWORK-MEDIATED SPECIFICITY
Descriptor:Designed protein 2L6HC3_12
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Boyken, S., Chen, Z., Groves, B., Langan, R.A., Oberdorfer, G., Ford, A., Gilmore, J., Xu, C., DiMaio, F., Seelig, G.
Deposit date:2016-03-28
Release date:2016-05-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5J0J
  • Download 5j0j
  • View 5j0j
Molmil generated image of 5j0j
DE NOVO DESIGN OF PROTEIN HOMO-OLIGOMERS WITH MODULAR HYDROGEN BOND NETWORK-MEDIATED SPECIFICITY
Descriptor:designed protein 2L6HC3_6
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Boyken, S., Chen, Z., Groves, B., Langan, R.A., Oberdorfer, G., Ford, A., Gilmore, J., Xu, C., DiMaio, F., Seelig, G.
Deposit date:2016-03-28
Release date:2016-05-25
Method:X-RAY DIFFRACTION (2.256 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5J0K
  • Download 5j0k
  • View 5j0k
Molmil generated image of 5j0k
DE NOVO DESIGN OF PROTEIN HOMO-OLIGOMERS WITH MODULAR HYDROGEN BOND NETWORK-MEDIATED SPECIFICITY
Descriptor:designed protein 2L4HC2_23
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Boyken, S., Chen, Z., Groves, B., Langan, R.A., Oberdorfer, G., Ford, A., Gilmore, J., Xu, C., DiMaio, F., Seelig, G.
Deposit date:2016-03-28
Release date:2016-05-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5J0L
  • Download 5j0l
  • View 5j0l
Molmil generated image of 5j0l
DE NOVO DESIGN OF PROTEIN HOMO-OLIGOMERS WITH MODULAR HYDROGEN BOND NETWORK-MEDIATED SPECIFICITY
Descriptor:designed protein 3L6HC2_2
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Boyken, S., Chen, Z., Groves, B., Langan, R.A., Oberdorfer, G., Ford, A., Gilmore, J., Xu, C., DiMaio, F., Seelig, G.
Deposit date:2016-03-28
Release date:2016-07-06
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5J10
  • Download 5j10
  • View 5j10
Molmil generated image of 5j10
DE NOVO DESIGN OF PROTEIN HOMO-OLIGOMERS WITH MODULAR HYDROGEN BOND NETWORK-MEDIATED SPECIFICITY
Descriptor:peptide design 2L4HC2_24
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Boyken, S., Chen, Z., Groves, B., Langan, R.A., Oberdorfer, G., Ford, A., Gilmore, J., Xu, C., DiMaio, F., Seelig, G.
Deposit date:2016-03-28
Release date:2016-05-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5J2L
  • Download 5j2l
  • View 5j2l
Molmil generated image of 5j2l
DE NOVO DESIGN OF PROTEIN HOMO-OLIGOMERS WITH MODULAR HYDROGEN BOND NETWORK-MEDIATED SPECIFICITY
Descriptor:protein design 2L4HC2_11
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Boyken, S., Chen, Z., Groves, B., Langan, R.A., Oberdorfer, G., Ford, A., Gilmore, J., Xu, C., DiMaio, F., Seelig, G.
Deposit date:2016-03-29
Release date:2016-05-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5J73
  • Download 5j73
  • View 5j73
Molmil generated image of 5j73
DE NOVO DESIGN OF PROTEIN HOMO-OLIGOMERS WITH MODULAR HYDROGEN BOND NETWORK-MEDIATED SPECIFICITY
Descriptor:protein design 2L4HC2_9
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Boyken, S., Chen, Z., Groves, B., Langan, R.A., Oberdorfer, G., Ford, A., Gilmore, J., Xu, C., DiMaio, F., Seelig, G.
Deposit date:2016-04-05
Release date:2016-05-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5JHI
  • Download 5jhi
  • View 5jhi
Molmil generated image of 5jhi
SOLUTION STRUCTURE OF THE DE NOVO MINI PROTEIN GEHE_06
Descriptor:W35
Authors:Buchko, G.W., Bahl, C.D., Gilmore, J.M., Pulavarti, S.V., Baker, D., Szyperski, T.
Deposit date:2016-04-21
Release date:2016-09-28
Last modified:2017-09-27
Method:SOLUTION NMR
Cite:Accurate de novo design of hyperstable constrained peptides.
Nature, 538, 2016
5JI4
  • Download 5ji4
  • View 5ji4
Molmil generated image of 5ji4
SOLUTION STRUCTURE OF THE DE NOVO MINI PROTEIN GEEHE_02
Descriptor:W37
Authors:Buchko, G.W., Bahl, C.D., Pulavarti, S.V., Baker, D., Szyperski, T.
Deposit date:2016-04-21
Release date:2016-09-28
Last modified:2016-11-02
Method:SOLUTION NMR
Cite:Accurate de novo design of hyperstable constrained peptides.
Nature, 538, 2016
5JQZ
  • Download 5jqz
  • View 5jqz
Molmil generated image of 5jqz
DESIGNED TWO-RING HOMOTETRAMER AT 3.8A RESOLUTION
Descriptor:De novo designed homotetramer
Authors:Sankaran, B., Zwart, P.H., Pereira, J.H., Baker, D., Oberdorfer, G., Boyken, S.E., Chen, Z.
Deposit date:2016-05-05
Release date:2016-06-29
Method:X-RAY DIFFRACTION (3.83 Å)
Cite:De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity.
Science, 352, 2016
5KPE
  • Download 5kpe
  • View 5kpe
Molmil generated image of 5kpe
SOLUTION NMR STRUCTURE OF DENOVO BETA SHEET DESIGN PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR664
Descriptor:De novo Beta Sheet Design Protein OR664
Authors:Tang, Y., Liu, G., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2016-07-03
Release date:2016-09-21
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
5L33
  • Download 5l33
  • View 5l33
Molmil generated image of 5l33
CRYSTAL STRUCTURE OF A DE NOVO DESIGNED PROTEIN WITH CURVED BETA-SHEET
Descriptor:denovo NTF2
Authors:Oberdorfer, G., Marcos, E., Basanta, B., Chidyausiku, T.M., Sankaran, B., Baker, D.
Deposit date:2016-08-03
Release date:2017-01-25
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
5TPH
  • Download 5tph
  • View 5tph
Molmil generated image of 5tph
CRYSTAL STRUCTURE OF A DE NOVO DESIGNED PROTEIN HOMODIMER WITH CURVED BETA-SHEET
Descriptor:de novo NTF2 homodimer, DI(HYDROXYETHYL)ETHER, CHLORIDE ION
Authors:Basanta, B., Marcos, E., Oberdorfer, G., Chidyausiku, T.M., Sankaran, B., Baker, D.
Deposit date:2016-10-20
Release date:2017-01-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017