2KUN
| Three dimensional structure of HuPrP(90-231 M129 Q212P) | Descriptor: | Major prion protein | Authors: | Ilc, G, Giachin, G, Jaremko, M, Jaremko, L, Zhukov, I, Plavec, J, Legname, G, Benetti, F. | Deposit date: | 2010-02-23 | Release date: | 2010-08-25 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | NMR structure of the human prion protein with the pathological Q212P mutation reveals unique structural features. Plos One, 5, 2010
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2MVK
| Solution structure of phosphorylated cytosolic part of Trop2 | Descriptor: | Tumor-associated calcium signal transducer 2 | Authors: | Ilc, G, Plavec, J, Vidmar, T, Pavsic, M, Lenarcic, B. | Deposit date: | 2014-10-08 | Release date: | 2015-05-06 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The cytosolic tail of the tumor marker protein Trop2--a structural switch triggered by phosphorylation. Sci Rep, 5, 2015
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2MVL
| Solution structure of cytosolic part of Trop2 | Descriptor: | Tumor-associated calcium signal transducer 2 | Authors: | Ilc, G, Plavec, J, Vidmar, T, Pavsic, M, Lenarcic, B. | Deposit date: | 2014-10-08 | Release date: | 2015-05-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The cytosolic tail of the tumor marker protein Trop2--a structural switch triggered by phosphorylation. Sci Rep, 5, 2015
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5LKN
| NMR solution structure of human FNIII domain 2 of NCAM | Descriptor: | Neural cell adhesion molecule 1 | Authors: | Slapsak, U, Salzano, G, Amin, L, Abskharon, R.N.N, Ilc, G, Zupancic, B, Biljan, I, Plavec, J, Giachin, G, Legname, G. | Deposit date: | 2016-07-22 | Release date: | 2016-09-14 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain. J.Biol.Chem., 291, 2016
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2LEJ
| human prion protein mutant HuPrP(90-231, M129, V210I) | Descriptor: | Major prion protein | Authors: | Biljan, I, Ilc, G, Giachin, G, Raspadori, A, Zhukov, I, Plavec, J, Legname, G. | Deposit date: | 2011-06-16 | Release date: | 2011-08-17 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Toward the Molecular Basis of Inherited Prion Diseases: NMR Structure of the Human Prion Protein with V210I Mutation. J.Mol.Biol., 412, 2011
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6FNV
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2LFT
| Human prion protein with E219K protective polymorphism | Descriptor: | Major prion protein | Authors: | Biljan, I, Ilc, G, Giacin, G, Zhukov, I, Plavec, J, Legname, G. | Deposit date: | 2011-07-14 | Release date: | 2012-06-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism. Biochem.J., 446, 2012
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2LSB
| Solution-state NMR structure of the human prion protein | Descriptor: | Major prion protein | Authors: | Biljan, I, Ilc, G, Giancin, G, Zhukov, I, Plavec, J, Legname, G. | Deposit date: | 2012-04-26 | Release date: | 2012-06-27 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism. Biochem.J., 446, 2012
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2LV1
| Solution-state NMR structure of prion protein mutant V210I at neutral pH | Descriptor: | Major prion protein | Authors: | Biljan, I, Ilc, G, Giachin, G, Legname, G, Plavec, J. | Deposit date: | 2012-06-26 | Release date: | 2012-09-19 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural Rearrangements at Physiological pH: Nuclear Magnetic Resonance Insights from the V210I Human Prion Protein Mutant. Biochemistry, 51, 2012
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5L6R
| PrP226* - Solution-state NMR structure of truncated human prion protein | Descriptor: | Major prion protein | Authors: | Kovac, V, Zupancic, B, Ilc, G, Curin Serbec, V, Plavec, J. | Deposit date: | 2016-05-31 | Release date: | 2016-10-05 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Truncated prion protein PrP226* - A structural view on its role in amyloid disease. Biochem. Biophys. Res. Commun., 484, 2017
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2MAE
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2N8Z
| Apo form of Calmodulin-Like Domain of Human Non-Muscle alpha-actinin 1 | Descriptor: | Alpha-actinin-1 | Authors: | Drmota Prebil, S, Slapsak, U, de Almeida Ribeiro, E, Pavsic, M, Ilc, G, Zielinska, K, Hartl, M, Backman, L, Plavec, J, Lenarcic, B, Djinovic-Carugo, K. | Deposit date: | 2015-10-28 | Release date: | 2016-06-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure and calcium-binding studies of calmodulin-like domain of human non-muscle alpha-actinin-1. Sci Rep, 6, 2016
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2N8Y
| Holo form of Calmodulin-Like Domain of Human Non-Muscle alpha-actinin 1 | Descriptor: | Alpha-actinin-1, CALCIUM ION | Authors: | Drmota Prebil, S, Slapsak, U, de Almeida Ribeiro, E, Pavsic, M, Ilc, G, Zielinska, K, Hartl, M, Backman, L, Plavec, J, Lenarcic, B, Djinovic-Carugo, K. | Deposit date: | 2015-10-28 | Release date: | 2016-06-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure and calcium-binding studies of calmodulin-like domain of human non-muscle alpha-actinin-1. Sci Rep, 6, 2016
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1XS7
| Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase). | Descriptor: | Beta-secretase 1, N-[(4S,5S,7R)-8-({(S)-1-[(BENZYLAMINO)OXOMETHYL]-2-METHYLPROPYL}AMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXO-OCT-4-YL]-(4S,7S)-4 -ISOPROPYL-2,5,9-TRIOXO-1-OXA-3,6,10-TRIAZACYCLOHEXADECANE-7-CARBOXAMIDE | Authors: | Ghosh, A, Devasamudram, T, Hong, L, DeZutter, C, Xu, X, Weerasena, V, Koelsch, G, Bilcer, G, Tang, J. | Deposit date: | 2004-10-18 | Release date: | 2004-12-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). Bioorg.Med.Chem.Lett., 15, 2005
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1HE7
| Human Nerve growth factor receptor TrkA | Descriptor: | GLYCEROL, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR | Authors: | Banfield, M, Robertson, A, Allen, S, Dando, J, Tyler, S, Bennett, G, Brain, S, Mason, G, Holden, P, Clarke, A, Naylor, R, Wilcock, G, Brady, R, Dawbarn, D. | Deposit date: | 2000-11-20 | Release date: | 2001-04-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Identification and Structure of the Nerve Growth Factor Binding Site on Trka. Biochem.Biophys.Res.Commun., 282, 2001
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2G94
| Crystal structure of beta-secretase bound to a potent and highly selective inhibitor. | Descriptor: | Beta-secretase 1, N~2~-[(2R,4S,5S)-5-{[N-{[(3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHOXY]CARBONYL}-3-(METHYLSULFONYL)-L-ALANYL]AMINO}-4-HYDROXY-2,7-DIMETHYLOCTANOYL]-N-ISOBUTYL-L-VALINAMIDE | Authors: | Hong, L, Ghosh, A, Tang, J. | Deposit date: | 2006-03-05 | Release date: | 2006-04-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. J.Am.Chem.Soc., 128, 2006
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2P4J
| Crystal structure of beta-secretase bond to an inhibitor with Isophthalamide Derivatives at P2-P3 | Descriptor: | Beta-secretase 1, N-[(1S,2S,4R)-2-HYDROXY-1-ISOBUTYL-5-({(1S)-1-[(ISOPROPYLAMINO)CARBONYL]-2-METHYLPROPYL}AMINO)-4-METHYL-5-OXOPENTYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N'-[(1R)-1-PHENYLETHYL]ISOPHTHALAMIDE | Authors: | Hong, L, Ghosh, A.K, Tang, J. | Deposit date: | 2007-03-12 | Release date: | 2007-07-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. J.Med.Chem., 50, 2007
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6N3W
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6N3Y
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6N3V
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6N3X
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2IEN
| Crystal structure analysis of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETIC ACID, CHLORIDE ION, ... | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Manna, D, Hussain, A.K, Leshchenko, S, Ghosh, A.K, Louis, J.M, Harrison, R.W, Weber, I.T. | Deposit date: | 2006-09-19 | Release date: | 2006-10-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains. J.Mol.Biol., 338, 2004
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