7V6K
| Crystal structure of Sortase A from Streptococcus pyogenes in complex with ML346 | Descriptor: | 5-[3-(4-methoxyphenyl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione, MAGNESIUM ION, Sortase | Authors: | Yang, C.G, Gan, J. | Deposit date: | 2021-08-20 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella. Rsc Med Chem, 13, 2022
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4MGT
| ALKBH2 R110A cross-linked to undamaged dsDNA | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, DNA1, DNA2, ... | Authors: | Chen, B, Gan, J, Yang, C.G. | Deposit date: | 2013-08-28 | Release date: | 2014-02-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The complex structures of ALKBH2 mutants cross-linked to
dsDNA reveal the conformational swing of β-hairpin Sci China Chem, 57, 2014
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4ZS3
| Structural complex of 5-aminofluorescein bound to the FTO protein | Descriptor: | 2-OXOGLUTARIC ACID, 5-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | Authors: | Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X. | Deposit date: | 2015-05-13 | Release date: | 2015-11-04 | Last modified: | 2015-11-18 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein J.Am.Chem.Soc., 137, 2015
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4ZS2
| Structural complex of FTO/fluorescein | Descriptor: | 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID, 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | Authors: | Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X. | Deposit date: | 2015-05-13 | Release date: | 2015-11-04 | Last modified: | 2015-11-18 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein J.Am.Chem.Soc., 137, 2015
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4QBA
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3OLJ
| Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) | Descriptor: | Ribonucleoside-diphosphate reductase subunit M2, SODIUM ION | Authors: | Chen, X.H, Xu, Z.J, Chen, B.E, Jiang, H.J, Yang, C.G, Zhu, W.L, Shao, J.M. | Deposit date: | 2010-08-26 | Release date: | 2011-08-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | hRRM2 To be Published
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5HLG
| Structure of reduced AbfR bound to DNA | Descriptor: | DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator | Authors: | Liu, G, Liu, X, Gan, J, Yang, C.G. | Deposit date: | 2016-01-15 | Release date: | 2017-01-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR. J. Am. Chem. Soc., 139, 2017
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4MG2
| ALKBH2 F102A cross-linked to undamaged dsDNA | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, DNA-1, DNA-2, ... | Authors: | Chen, B, Gan, J, Yang, C.G. | Deposit date: | 2013-08-28 | Release date: | 2014-02-26 | Last modified: | 2014-06-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The complex structures of ALKBH2 mutants cross-linked to
dsDNA reveal the conformational swing of β-hairpin Sci China Chem, 57, 2014
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3BU0
| crystal structure of human ABH2 cross-linked to dsDNA with cofactors | Descriptor: | 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, DNA (5'-D(*CP*TP*GP*TP*AP*TP*(2YR)P*AP*TP*TP*GP*CP*G)-3'), ... | Authors: | Yang, C.-G, Yi, C, He, C. | Deposit date: | 2007-12-31 | Release date: | 2008-04-22 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature, 452, 2008
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3BTX
| X-ray structure of human ABH2 bound to dsDNA through active site cross-linking | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, DNA (5'-D(*CP*TP*GP*TP*AP*TP*(2YR)P*AP*TP*TP*GP*CP*G)-3'), DNA (5'-D(*DTP*DCP*DGP*DCP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*DCP*DA)-3'), ... | Authors: | Yang, C.-G, Yi, C, He, C. | Deposit date: | 2007-12-31 | Release date: | 2008-04-22 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature, 452, 2008
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3BI3
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3BTY
| Crystal structure of human ABH2 bound to dsDNA containing 1meA through cross-linking away from active site | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, DNA (5'-D(*DCP*DTP*DGP*DTP*DAP*DTP*(MA7)P*DAP*DCP*DTP*DGP*DCP*DG)-3'), DNA (5'-D(*DTP*DCP*DGP*DCP*DAP*DGP*DTP*DTP*DAP*DTP*DAP*DCP*DA)-3'), ... | Authors: | Yang, C.-G, Yi, C, He, C. | Deposit date: | 2007-12-31 | Release date: | 2008-04-22 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature, 452, 2008
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3BTZ
| Crystal structure of human ABH2 cross-linked to dsDNA | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, DNA (5'-D(*AP*GP*GP*TP*GP*AP*(2YR)P*AP*AP*TP*GP*CP*G)-3'), DNA (5'-D(*DTP*DCP*DGP*DCP*DAP*DTP*DTP*DAP*DTP*DCP*DAP*DCP*DC)-3') | Authors: | Yang, C.-G, Yi, C, He, C. | Deposit date: | 2007-12-31 | Release date: | 2008-04-22 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature, 452, 2008
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3BUC
| X-ray structure of human ABH2 bound to dsDNA with Mn(II) and 2KG | Descriptor: | 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, DNA (5'-D(*DCP*DTP*DGP*DTP*DAP*DTP*(MA7)P*DAP*DCP*DTP*DGP*DCP*DG)-3'), ... | Authors: | Yang, C.-G, Yi, C, He, C. | Deposit date: | 2008-01-02 | Release date: | 2008-04-22 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature, 452, 2008
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3RZH
| Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage | Descriptor: | 5'-D(*CP*TP*GP*TP*CP*TP*(ME6)P*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*GP*AP*GP*AP*CP*A)-3', Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, ... | Authors: | Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C. | Deposit date: | 2011-05-11 | Release date: | 2012-06-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Duplex interrogation by a direct DNA repair protein in search of base damage Nat.Struct.Mol.Biol., 19, 2012
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3RZG
| Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage | Descriptor: | 5'-D(*CP*TP*GP*TP*CP*AP*TP*CP*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*GP*AP*TP*GP*AP*CP*A)-3', Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, ... | Authors: | Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C. | Deposit date: | 2011-05-11 | Release date: | 2012-06-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Duplex interrogation by a direct DNA repair protein in search of base damage Nat.Struct.Mol.Biol., 19, 2012
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3RZM
| Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage | Descriptor: | 5'-D(*AP*TP*GP*TP*AP*TP*AP*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*TP*AP*TP*AP*CP*A)-3', Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, ... | Authors: | Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C. | Deposit date: | 2011-05-11 | Release date: | 2012-06-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | Duplex interrogation by a direct DNA repair protein in search of base damage Nat.Struct.Mol.Biol., 19, 2012
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3RZK
| Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage | Descriptor: | 2-OXOGLUTARIC ACID, 5'-D(*CP*TP*GP*TP*CP*TP*(EDA)P*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*TP*AP*GP*AP*CP*A)-3', ... | Authors: | Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C. | Deposit date: | 2011-05-11 | Release date: | 2012-06-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Duplex interrogation by a direct DNA repair protein in search of base damage Nat.Struct.Mol.Biol., 19, 2012
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3RZJ
| Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage | Descriptor: | 2-OXOGLUTARIC ACID, 5'-D(*CP*TP*GP*TP*CP*TP*(ME6)P*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*GP*AP*GP*AP*CP*A)-3', ... | Authors: | Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C. | Deposit date: | 2011-05-11 | Release date: | 2012-06-06 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Duplex interrogation by a direct DNA repair protein in search of base damage Nat.Struct.Mol.Biol., 19, 2012
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6IHT
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6IHL
| Crystal structure of bacterial serine phosphatase | Descriptor: | MAGNESIUM ION, Phosphorylated protein phosphatase | Authors: | Yang, C.-G, yang, T. | Deposit date: | 2018-09-30 | Release date: | 2019-08-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.573 Å) | Cite: | Structural Insight into the Mechanism of Staphylococcus aureus Stp1 Phosphatase. Acs Infect Dis., 5, 2019
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6IHW
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6IHV
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6IHU
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8HGK
| Crystal structure of human ClpP in complex with ZK53 | Descriptor: | 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | Authors: | Yang, C.-G, Gan, J.H, Zhou, L.-L. | Deposit date: | 2022-11-14 | Release date: | 2023-09-27 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma. Nat Commun, 14, 2023
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