7V6K
Crystal structure of Sortase A from Streptococcus pyogenes in complex with ML346
Summary for 7V6K
| Entry DOI | 10.2210/pdb7v6k/pdb |
| Descriptor | Sortase, 5-[3-(4-methoxyphenyl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | sortase a, transpetidase, hydrolase |
| Biological source | Streptococcus pyogenes |
| Total number of polymer chains | 2 |
| Total formula weight | 42116.49 |
| Authors | Yang, C.G.,Gan, J. (deposition date: 2021-08-20, release date: 2021-12-29, Last modification date: 2023-11-29) |
| Primary citation | Guan, X.N.,Zhang, T.,Yang, T.,Dong, Z.,Yang, S.,Lan, L.,Gan, J.,Yang, C.G. Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella. Rsc Med Chem, 13:138-149, 2022 Cited by PubMed: 35308030DOI: 10.1039/d1md00316j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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