4G5R | | STRUCTURE OF LGN GL4/GALPHAI3 COMPLEX | | Descriptor: | Guanine nucleotide-binding protein G(k) subunit alpha, G-protein-signaling modulator 2, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Jia, M., Li, J., Zhu, J., Wen, W., Zhang, M., Wang, W. | | Deposit date: | 2012-07-18 | | Release date: | 2012-09-05 | | Method: | X-RAY DIFFRACTION (3.481 Å) | | Cite: | Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Galphai subunits in G-coupled heterotrimeric proteins
To be Published
|
|
4H6J | | IDENTIFICATION OF CYS 255 IN HIF-1 AS A NOVEL SITE FOR DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 /ARNT PASB DOMAIN PROTEIN-PROTEIN INTERACTION. | | Descriptor: | HYPOXIA INDUCIBLE FACTOR 1-ALPHA, ARYL HYDROCARBON NUCLEAR TRANSLOCATOR | | Authors: | Cardoso, R., Love, R.A., Nilsson, C., Bergqvist, S., Nowlin, D., Yan, J., Liu, K., Zhu, J., Chen, P., Deng, Y.-L., Dyson, H.J., Greig, M.J., Brooun, A. | | Deposit date: | 2012-09-19 | | Release date: | 2012-12-05 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Identification of Cys255 in HIF-1 alpha as a novel site for development of covalent inhibitors of HIF-1 alpha /ARNT PasB domain protein-protein interaction.
Protein Sci., 21, 2012
|
|
4HJW | | CRYSTAL STRUCTURE OF METARHIZIUM ANISOPLIAE IDCASE IN APO FORM | | Descriptor: | Uracil-5-carboxylate decarboxylase, ZINC ION | | Authors: | Xu, S., Zhu, J., Ding, J. | | Deposit date: | 2012-10-14 | | Release date: | 2013-09-11 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
|
|
4HK5 | | CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE IN APO FORM | | Descriptor: | Uracil-5-carboxylate decarboxylase, ZINC ION | | Authors: | Xu, S., Zhu, J., Ding, J. | | Deposit date: | 2012-10-15 | | Release date: | 2013-09-11 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
|
|
4HK6 | |
4HK7 | | CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE IN COMPLEX WITH URACIL | | Descriptor: | Uracil-5-carboxylate decarboxylase, ZINC ION, URACIL | | Authors: | Xu, S., Zhu, J., Ding, J. | | Deposit date: | 2012-10-15 | | Release date: | 2013-09-11 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.189 Å) | | Cite: | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
|
|
4LAK | | CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE D323N MUTANT IN APO FORM | | Descriptor: | Uracil-5-carboxylate decarboxylase, ZINC ION | | Authors: | Xu, S., Li, W., Zhu, J., Wang, R., Li, Z., Xu, G.L., Ding, J. | | Deposit date: | 2013-06-20 | | Release date: | 2013-10-02 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
|
|
4LAL | | CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE D323A MUTANT IN COMPLEX WITH 5-CARBOXYL-URACIL | | Descriptor: | Uracil-5-carboxylate decarboxylase, ZINC ION, 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, ... | | Authors: | Xu, S., Li, W., Zhu, J., Ding, J. | | Deposit date: | 2013-06-20 | | Release date: | 2013-10-02 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
|
|
4LAM | | CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE D323N MUTANT IN COMPLEX WITH 5-CARBOXYL-URACIL | | Descriptor: | Uracil-5-carboxylate decarboxylase, ZINC ION, 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, ... | | Authors: | Xu, S., Li, W., Zhu, J., Ding, J. | | Deposit date: | 2013-06-20 | | Release date: | 2013-10-02 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
|
|
4LAN | | CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE H195A MUTANT | | Descriptor: | Uracil-5-carboxylate decarboxylase, ZINC ION | | Authors: | Xu, S., Li, W., Zhu, J., Ding, J. | | Deposit date: | 2013-06-20 | | Release date: | 2013-10-02 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
|
|
4LAO | | CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE H195A MUTANT (ZN) | | Descriptor: | Cordyceps militaris IDCase, ZINC ION, DI(HYDROXYETHYL)ETHER | | Authors: | Xu, S., Li, W., Zhu, J., Ding, J. | | Deposit date: | 2013-06-20 | | Release date: | 2013-10-02 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
|
|
4UQ8 | | ELECTRON CRYO-MICROSCOPY OF BOVINE COMPLEX I | | Descriptor: | NADH UBIQUINONE OXIDOREDUCTASE CHAIN 3, NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL, ... | | Authors: | Vinothkumar, K.R., Zhu, J., Hirst, J. | | Deposit date: | 2014-06-21 | | Release date: | 2014-10-01 | | Last modified: | 2017-08-02 | | Method: | ELECTRON MICROSCOPY (4.95 Å) | | Cite: | Architecture of Mammalian Respiratory Complex I.
Nature, 515, 2014
|
|
5GK9 | | CRYSTAL STRUCTURE OF HUMAN HBO1 IN COMPLEX WITH BRPF2 | | Descriptor: | Histone acetyltransferase KAT7, BRD1 protein, ZINC ION, ... | | Authors: | Tao, Y., Zhu, J., Xu, S., Ding, J. | | Deposit date: | 2016-07-04 | | Release date: | 2017-03-29 | | Last modified: | 2017-12-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2.
Nucleic Acids Res., 45, 2017
|
|
6JJ3 | | BRD4 IN COMPLEX WITH 138A | | Descriptor: | Bromodomain-containing protein 4, 2-methoxy-N-[2-methyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]benzenesulfonamide | | Authors: | Xu, J., Chen, Y., Jiang, F., Zhu, J. | | Deposit date: | 2019-02-25 | | Release date: | 2020-01-22 | | Method: | X-RAY DIFFRACTION (1.718 Å) | | Cite: | Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.
J.Med.Chem., 62, 2019
|
|
6JJ5 | | BRD4 IN COMPLEX WITH 259 | | Descriptor: | Bromodomain-containing protein 4, 3-((1-methyl-2-oxo-1,2,2a1,5a-tetrahydro-6H-pyrido[3',2':6,7]azepino[4,3,2-cd]isoindol-6-yl)methyl)benzamide | | Authors: | Xu, J., Chen, Y., Jiang, F., Zhu, J. | | Deposit date: | 2019-02-25 | | Release date: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | BRD4 in complex with ZZM1
To Be Published
|
|
6JJ6 | | BRD4 IN COMPLEX WITH 500 | | Descriptor: | Bromodomain-containing protein 4, 1-methyl-6-(3-(4-methylpiperazine-1-carbonyl)benzyl)-1,2a1,5a,6-tetrahydro-2H-pyrido[3',2':6,7]azepino[4,3,2-cd]isoindol-2-one | | Authors: | Xu, J., Chen, Y., Jiang, F., Zhu, J. | | Deposit date: | 2019-02-25 | | Release date: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | BRD4 in complex with ZZM1
To Be Published
|
|
6JJB | | BRD4 IN COMPLEX WITH ZZM1 | | Descriptor: | Bromodomain-containing protein 4, 2-methoxy-N-(1-methyl-2-oxidanylidene-benzo[cd]indol-6-yl)benzenesulfonamide | | Authors: | Xu, J., Chen, Y., Jiang, F., Zhu, J. | | Deposit date: | 2019-02-25 | | Release date: | 2020-01-22 | | Method: | X-RAY DIFFRACTION (1.508 Å) | | Cite: | Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.
J.Med.Chem., 62, 2019
|
|
6JLS | | CRYSTAL STRUCTURE OF FMN-DEPENDENT CYSTEINE DECARBOXYLASES TVAF FROM THIOVIRIDAMIDE BIOSYNTHESIS | | Descriptor: | Putative flavoprotein decarboxylase, FLAVIN MONONUCLEOTIDE | | Authors: | Li, J., Lu, J., Wang, H., Zhu, J. | | Deposit date: | 2019-03-06 | | Release date: | 2019-06-26 | | Last modified: | 2019-07-10 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Characterization of the FMN-Dependent Cysteine Decarboxylase from Thioviridamide Biosynthesis.
Org.Lett., 21, 2019
|
|
1P4A | | CRYSTAL STRUCTURE OF THE PURR COMPLEXED WITH CPRPP | | Descriptor: | Pur operon repressor, 1-ALPHA-PYROPHOSPHORYL-2-ALPHA,3-ALPHA-DIHYDROXY-4-BETA-CYCLOPENTANE-METHANOL-5-PHOSPHATE | | Authors: | Bera, A.K., Zhu, J., Zalkin, H., Smith, J.L. | | Deposit date: | 2003-04-22 | | Release date: | 2003-12-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Functional dissection of the Bacillus subtilis pur operator site.
J.Bacteriol., 185, 2003
|
|
1YCL | | CRYSTAL STRUCTURE OF B. SUBTILIS LUXS IN COMPLEX WITH A CATALYTIC 2-KETONE INTERMEDIATE | | Descriptor: | S-ribosylhomocysteinase, COBALT (II) ION, SULFATE ION, ... | | Authors: | Rajan, R., Zhu, J., Hu, X., Pei, D., Bell, C.E. | | Deposit date: | 2004-12-22 | | Release date: | 2005-03-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of S-Ribosylhomocysteinase (LuxS) in Complex with a Catalytic 2-Ketone Intermediate.
Biochemistry, 44, 2005
|
|
2FQO | | CRYSTAL STRUCTURE OF B. SUBTILIS LUXS IN COMPLEX WITH (2S)-2-AMINO-4-[(2R,3R)-2,3-DIHYDROXY-3-N- HYDROXYCARBAMOYL-PROPYLMERCAPTO]BUTYRIC ACID | | Descriptor: | S-ribosylhomocysteine lyase, COBALT (II) ION, SULFATE ION, ... | | Authors: | Shen, G., Rajan, R., Zhu, J., Bell, C.E., Pei, D. | | Deposit date: | 2006-01-18 | | Release date: | 2006-05-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Design and Synthesis of Substrate and Intermediate Analogue Inhibitors of S-Ribosylhomocysteinase
J.Med.Chem., 49, 2006
|
|
2FQT | | CRYSTAL STRUCTURE OF B.SUBTILIS LUXS IN COMPLEX WITH (2S)-2-AMINO-4-[(2R,3S)-2,3-DIHYDROXY-3-N-HYDROXYCARBAMOYL-PROPYLMERCAPTO]BUTYRIC ACID | | Descriptor: | S-ribosylhomocysteine lyase, SULFATE ION, COBALT (II) ION, ... | | Authors: | Shen, G., Rajan, R., Zhu, J., Bell, C.E., Pei, D. | | Deposit date: | 2006-01-18 | | Release date: | 2006-05-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Design and Synthesis of Substrate Analogue Inhibitors of S-Ribosylhomocysteinase (LuxS)
J.Med.Chem., 49, 2006
|
|
2IC7 | | CRYSTAL STRUCTURE OF MALTOSE TRANSACETYLASE FROM GEOBACILLUS KAUSTOPHILUS | | Descriptor: | Maltose transacetylase | | Authors: | Liu, Z.J., Li, Y., Chen, L., Zhu, J., Rose, J.P., Ebihara, A., Yokoyama, S., Wang, B.C., Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI), RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-09-12 | | Release date: | 2006-11-07 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Crystal Structure of Maltose Transacetylase From Geobacillus kaustophilus at 1.78 Angstrom Resolution
To be Published
|
|
2LIR | | NMR SOLUTION STRUCTURE OF YEAST ISO-1-CYTOCHROME C MUTANT P71H IN OXIDIZED STATES | | Descriptor: | Cytochrome c iso-1, HEME C | | Authors: | Lan, W., Wang, Z., Yang, Z., Zhu, J., Ying, T., Jiang, X., Zhang, X., Wu, H., Liu, M., Tan, X., Cao, C., Huang, Z.X. | | Deposit date: | 2011-08-31 | | Release date: | 2011-12-07 | | Method: | SOLUTION NMR | | Cite: | Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced States.
Plos One, 6, 2011
|
|
2LIT | | NMR SOLUTION STRUCTURE OF YEAST ISO-1-CYTOCHROME C MUTANT P71H IN REDUCED STATES | | Descriptor: | Cytochrome c iso-1, HEME C | | Authors: | Lan, W., Wang, Z., Yang, Z., Zhu, J., Ying, T., Jiang, X., Zhang, X., Wu, H., Liu, M., Tan, X., Cao, C., Huang, Z.X. | | Deposit date: | 2011-08-31 | | Release date: | 2011-12-07 | | Method: | SOLUTION NMR | | Cite: | Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced States.
Plos One, 6, 2011
|
|
