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424D
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BU of 424d by Molmil
5'-D(*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3'
Descriptor: DNA (5'-D(*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3')
Authors:Rozenberg, H, Rabinovich, D, Frolow, F, Hegde, R.S, Shakked, Z.
Deposit date:1998-09-14
Release date:1999-10-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural code for DNA recognition revealed in crystal structures of papillomavirus E2-DNA targets.
Proc.Natl.Acad.Sci.USA, 95, 1998
425D
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BU of 425d by Molmil
5'-D(*AP*CP*CP*GP*GP*TP*AP*CP*CP*GP*GP*T)-3'
Descriptor: DNA (5'-D(*AP*CP*CP*GP*GP*TP*AP*CP*CP*GP*GP*T)-3')
Authors:Rozenberg, H, Rabinovich, D, Frolow, F, Hegde, R.S, Shakked, Z.
Deposit date:1998-09-14
Release date:1999-10-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural code for DNA recognition revealed in crystal structures of papillomavirus E2-DNA targets.
Proc.Natl.Acad.Sci.USA, 95, 1998
423D
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BU of 423d by Molmil
5'-D(*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3'
Descriptor: DNA (5'-D(*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3'), MAGNESIUM ION
Authors:Rozenberg, H, Rabinovich, D, Frolow, F, Hegde, R.S, Shakked, Z.
Deposit date:1998-09-14
Release date:1999-10-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural code for DNA recognition revealed in crystal structures of papillomavirus E2-DNA targets.
Proc.Natl.Acad.Sci.USA, 95, 1998
3KZ8
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BU of 3kz8 by Molmil
Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3)
Descriptor: Cellular tumor antigen p53, DNA (5'-D(*TP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*C)-3'), IODIDE ION, ...
Authors:Rozenberg, H, Suad, O, Shakked, Z.
Deposit date:2009-12-08
Release date:2010-03-31
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs
Nat.Struct.Mol.Biol., 17, 2010
5MF7
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BU of 5mf7 by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-GADD45)
Descriptor: Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, DNA, ...
Authors:Rozenberg, H, Diskin-Posner, Y, Golovenko, D, Shakked, Z.
Deposit date:2016-11-17
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
5MG7
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BU of 5mg7 by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-p53R2)
Descriptor: Cellular tumor antigen p53, DNA, ZINC ION
Authors:Rozenberg, H, Braeuning, B, Golovenko, D, Shakked, Z.
Deposit date:2016-11-21
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
6ZNC
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BU of 6znc by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (I)
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ...
Authors:Rozenberg, H, Degtjarik, O, Diskin-Posner, Y, Shakked, Z.
Deposit date:2020-07-06
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
4P3C
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BU of 4p3c by Molmil
MT1-MMP:Fab complex (Form I)
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ...
Authors:Rozenberg, H, Udi, Y, Sagi, I.
Deposit date:2014-03-06
Release date:2014-12-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.943 Å)
Cite:Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.
Structure, 23, 2015
4P3D
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BU of 4p3d by Molmil
MT1-MMP:Fab complex (Form II)
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Rozenberg, H, Udi, Y, Sagi, I.
Deposit date:2014-03-07
Release date:2014-12-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.
Structure, 23, 2015
3D09
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BU of 3d09 by Molmil
Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Rozenberg, H, Suad, O, Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D06
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BU of 3d06 by Molmil
Human p53 core domain with hot spot mutation R249S (I)
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Rozenberg, H, Suad, O, Shimon, L.J.W, Frolow, F, Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
4IBQ
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BU of 4ibq by Molmil
Human p53 core domain with hot spot mutation R273C
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ...
Authors:Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IBS
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BU of 4ibs by Molmil
Human p53 core domain with hot spot mutation R273H (form I)
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, ZINC ION
Authors:Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IJT
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BU of 4ijt by Molmil
Human p53 core domain with hot spot mutation R273H (form II)
Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Cellular tumor antigen p53, ...
Authors:Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z.
Deposit date:2012-12-23
Release date:2013-08-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
7B4D
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BU of 7b4d by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ...
Authors:Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B4N
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BU of 7b4n by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II)
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ...
Authors:Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B49
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BU of 7b49 by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ...
Authors:Rozenberg, H, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B4F
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BU of 7b4f by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I)
Descriptor: Cellular tumor antigen p53, DNA target, FORMIC ACID, ...
Authors:Rozenberg, H, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7NBN
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BU of 7nbn by Molmil
Allostery through DNA drives phenotype switching
Descriptor: AddAB promoter
Authors:Rosenblum, G, Elad, N, Rozenberg, H, Wiggers, F, Jungwirth, J, Hofmann, H.
Deposit date:2021-01-27
Release date:2021-04-07
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Allostery through DNA drives phenotype switching.
Nat Commun, 12, 2021
2ADY
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BU of 2ady by Molmil
Structural Basis of DNA Recognition by p53 Tetramers (complex IV)
Descriptor: 5'-D(*CP*GP*GP*AP*CP*AP*TP*GP*TP*CP*CP*G)-3', Cellular tumor antigen p53, ZINC ION
Authors:Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z.
Deposit date:2005-07-21
Release date:2006-07-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of DNA Recognition by p53 Tetramers
Mol.Cell, 22, 2006
2AC0
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BU of 2ac0 by Molmil
Structural Basis of DNA Recognition by p53 Tetramers (complex I)
Descriptor: 5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3', Cellular tumor antigen p53, ZINC ION
Authors:Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z.
Deposit date:2005-07-18
Release date:2006-07-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of DNA Recognition by p53 Tetramers
Mol.Cell, 22, 2006
2ATA
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BU of 2ata by Molmil
Structural Basis of DNA Recognition by p53 Tetramers (complex II)
Descriptor: 5'-D(*AP*AP*GP*GP*CP*AP*TP*GP*CP*CP*TP*T)-3', Cellular tumor antigen p53, ZINC ION
Authors:Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z.
Deposit date:2005-08-24
Release date:2006-07-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis of DNA Recognition by p53 Tetramers
Mol.Cell, 22, 2006
5MCU
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BU of 5mcu by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG2)
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ...
Authors:Golovenko, D, Rozenberg, H, Shakked, Z.
Deposit date:2016-11-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
5MCV
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BU of 5mcv by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC1)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ...
Authors:Golovenko, D, Rozenberg, H, Shakked, Z.
Deposit date:2016-11-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
5MCW
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BU of 5mcw by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC2)
Descriptor: Cellular tumor antigen p53, DNA, FORMYL GROUP, ...
Authors:Golovenko, D, Rozenberg, H, Shakked, Z.
Deposit date:2016-11-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018

 

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