5E0O
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2A6J
| Crystal structure analysis of the anti-arsonate germline antibody 36-65 | Descriptor: | Germline antibody 36-65 Fab heavy chain, Germline antibody 36-65 Fab light chain | Authors: | Sethi, D.K, Agarwal, A, Manivel, V, Rao, K.V, Salunke, D.M. | Deposit date: | 2005-07-02 | Release date: | 2006-06-13 | Last modified: | 2018-03-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response. Immunity, 24, 2006
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2A6I
| Crystal structure analysis of the anti-arsonate germline antibody 36-65 in complex with a phage display derived dodecapeptide KLASIPTHTSPL | Descriptor: | Dodecapeptide: KLASIPTHTSPL, Germline antibody 36-65 Fab heavy chain, Germline antibody 36-65 Fab light chain | Authors: | Sethi, D.K, Agarwal, A, Manivel, V, Rao, K.V, Salunke, D.M. | Deposit date: | 2005-07-02 | Release date: | 2006-06-13 | Last modified: | 2018-03-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response. Immunity, 24, 2006
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2A6D
| Crystal structure analysis of the anti-arsonate germline antibody 36-65 in complex with a phage display derived dodecapeptide RLLIADPPSPRE | Descriptor: | Dodecapeptide, RLLIADPPSPRE, Germline antibody 36-65 Fab Heavy chain, ... | Authors: | Sethi, D.K, Agarwal, A, Manivel, V, Rao, K.V, Salunke, D.M. | Deposit date: | 2005-07-02 | Release date: | 2006-06-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response. Immunity, 24, 2006
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2A6K
| Crystal Structure Analysis of the germline antibody 36-65 Fab in complex with the dodecapeptide SLGDNLTNHNLR | Descriptor: | DODECAPEPTIDE: SLGDNLTNHNLR, Germline antibody 36-65 Fab heavy chain, Germline antibody 36-65 Fab light chain | Authors: | Sethi, D.K, Agarwal, A, Manivel, V, Rao, K.V, Salunke, D.M. | Deposit date: | 2005-07-03 | Release date: | 2006-06-13 | Last modified: | 2018-03-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response. Immunity, 24, 2006
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7ESS
| Structure-guided studies of the Holliday junction resolvase RuvX provide novel insights into ATP-stimulated cleavage of branched DNA and RNA substrates | Descriptor: | Putative pre-16S rRNA nuclease | Authors: | Thakur, M, Mohan, D, Singh, A.K, Agarwal, A, Gopal, B, Muniyappa, K. | Deposit date: | 2021-05-11 | Release date: | 2021-05-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Novel insights into ATP-Stimulated Cleavage of branched DNA and RNA Substrates through Structure-Guided Studies of the Holliday Junction Resolvase RuvX. J.Mol.Biol., 433, 2021
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2GC8
| Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase | Descriptor: | 1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE, RNA-directed RNA polymerase | Authors: | Gopalsamy, A, Chopra, R, Lim, K, Ciszewski, G, Shi, M, Curran, K.J, Sukits, S.F, Svenson, K, Bard, J, Ellingboe, J.W, Agarwal, A, Krishnamurthy, G, Howe, A.Y, Orlowski, M, Feld, B, O'connell, J, Mansour, T.S. | Deposit date: | 2006-03-13 | Release date: | 2006-06-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of Proline Sulfonamides as Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site. J.Med.Chem., 49, 2006
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7U9G
| Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein, RVA122 Fab Heavy Chain, ... | Authors: | Callaway, H.M, Zyla, D, Larrous, F, Dias de Melo, G, Hastie, K.M, Avalos, R.D, Agarwal, A, Bouhry, H, Corti, D, Saphire, E.O. | Deposit date: | 2022-03-10 | Release date: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Sci Adv, 8, 2022
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1Q2P
| SHV-1 class A beta-lactamase complexed with penem WAY185229 | Descriptor: | (6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, beta-lactamase SHV-1 | Authors: | Nukaga, M, Venkatesan, A.M, Mansour, T.S, Hujer, A, Bonomo, R.A, Knox, J.R. | Deposit date: | 2003-07-25 | Release date: | 2004-09-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates J.Med.Chem., 47, 2004
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1Q2Q
| Enterobacter cloacae GC1 class C beta-lactamase complexed with penem WAY185229 | Descriptor: | (6,7-DIHYDRO-5H-CYCLOPENTA[D]IMIDAZO[2,1-B]THIAZOL-2-YL]-4,7-DIHYDRO[1,4]THIAZEPINE-3,6-DICARBOXYLIC ACID, GLYCEROL, class C beta-lactamase | Authors: | Nukaga, M, Venkatesan, A.M, Mansour, T.S, Hujer, A, Bonomo, R.A, Knox, J.R. | Deposit date: | 2003-07-25 | Release date: | 2004-09-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates J.Med.Chem., 47, 2004
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2QE5
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2QE2
| Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor | Descriptor: | 2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID, RNA-directed RNA polymerase | Authors: | Chopra, R, Svenson, K, Bard, J. | Deposit date: | 2007-06-22 | Release date: | 2007-10-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase J.Med.Chem., 50, 2007
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5VGA
| Alternative model for Fab 36-65 | Descriptor: | Fab 36-65 heavy chain, Fab 36-65 light chain, TRIETHYLENE GLYCOL | Authors: | Stanfield, R.L, Rupp, B, Wlodawer, A, Dauter, Z, Porebski, P.J, Minor, W, Jaskolski, M, Pozharski, E, Weichenberger, C.X. | Deposit date: | 2017-04-10 | Release date: | 2017-12-06 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Detect, correct, retract: How to manage incorrect structural models. FEBS J., 285, 2018
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6VC8
| Crystal structure of wild-type KRAS4b(1-169) in complex with GMPPNP and Mg ion | Descriptor: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | Authors: | Tran, T.H, Davies, D.R, Edwards, T.E, Simanshu, D.K. | Deposit date: | 2019-12-20 | Release date: | 2021-02-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7T3F
| Development of BRD4 inhibitors as arsenicals antidotes | Descriptor: | 4-fluoro-3-methyl-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzene-1-sulfonamide, Bromodomain-containing protein 4, GLYCEROL | Authors: | Wu, M, Yatchang, M, Mathew, B, Zhai, L, Ruiz, P, Bostwick, R, Augelli-Szafran, C.E, Suto, M.J. | Deposit date: | 2021-12-07 | Release date: | 2022-08-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals. Bioorg.Med.Chem.Lett., 64, 2022
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2JJF
| N328A mutant of M. tuberculosis Rv3290c | Descriptor: | L-LYSINE EPSILON AMINOTRANSFERASE | Authors: | tripathi, S.M, Ramachandran, R. | Deposit date: | 2008-04-04 | Release date: | 2009-06-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Mutational Analysis of Mycobacterium Tuberculosis Lysine Epsilon-Aminotransferase and Inhibitor Co-Crystal Structures, Reveals Distinct Binding Modes. Biochem.Biophys.Res.Commun., 463, 2015
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2JJH
| E243 mutant of M. tuberculosis Rv3290C | Descriptor: | 2-OXOGLUTARIC ACID, L-LYSINE EPSILON AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Tripathi, S.M, Ramachandran, R. | Deposit date: | 2008-04-04 | Release date: | 2009-06-30 | Last modified: | 2020-01-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mutational Analysis of Mycobacterium Tuberculosis Lysine Epsilon-Aminotransferase and Inhibitor Co-Crystal Structures, Reveals Distinct Binding Modes. Biochem.Biophys.Res.Commun., 463, 2015
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2JJG
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2JJE
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