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4LAK
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CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE D323N MUTANT IN APO FORM
Descriptor:Uracil-5-carboxylate decarboxylase, ZINC ION
Authors:Xu, S., Li, W., Zhu, J., Wang, R., Li, Z., Xu, G.L., Ding, J.
Deposit date:2013-06-20
Release date:2013-10-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
4LAL
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CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE D323A MUTANT IN COMPLEX WITH 5-CARBOXYL-URACIL
Descriptor:Uracil-5-carboxylate decarboxylase, ZINC ION, 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, ...
Authors:Xu, S., Li, W., Zhu, J., Ding, J.
Deposit date:2013-06-20
Release date:2013-10-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
4LAM
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CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE D323N MUTANT IN COMPLEX WITH 5-CARBOXYL-URACIL
Descriptor:Uracil-5-carboxylate decarboxylase, ZINC ION, 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, ...
Authors:Xu, S., Li, W., Zhu, J., Ding, J.
Deposit date:2013-06-20
Release date:2013-10-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
4LAN
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CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE H195A MUTANT
Descriptor:Uracil-5-carboxylate decarboxylase, ZINC ION
Authors:Xu, S., Li, W., Zhu, J., Ding, J.
Deposit date:2013-06-20
Release date:2013-10-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
4LAO
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CRYSTAL STRUCTURE OF CORDYCEPS MILITARIS IDCASE H195A MUTANT (ZN)
Descriptor:Cordyceps militaris IDCase, ZINC ION, DI(HYDROXYETHYL)ETHER
Authors:Xu, S., Li, W., Zhu, J., Ding, J.
Deposit date:2013-06-20
Release date:2013-10-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Cell Res., 23, 2013
4UQ8
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ELECTRON CRYO-MICROSCOPY OF BOVINE COMPLEX I
Descriptor:NADH UBIQUINONE OXIDOREDUCTASE CHAIN 3, NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL, ...
Authors:Vinothkumar, K.R., Zhu, J., Hirst, J.
Deposit date:2014-06-21
Release date:2014-10-01
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.95 Å)
Cite:Architecture of Mammalian Respiratory Complex I.
Nature, 515, 2014
5GK9
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CRYSTAL STRUCTURE OF HUMAN HBO1 IN COMPLEX WITH BRPF2
Descriptor:Histone acetyltransferase KAT7, BRD1 protein, ZINC ION, ...
Authors:Tao, Y., Zhu, J., Xu, S., Ding, J.
Deposit date:2016-07-04
Release date:2017-03-29
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2.
Nucleic Acids Res., 45, 2017
5XZR
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THE ATOMIC STRUCTURE OF SHP2 E76A MUTANT IN COMPLEX WITH ALLOSTERIC INHIBITOR 9B
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, 4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine
Authors:Li, D., Xie, J., Zhu, J., Liu, C.
Deposit date:2017-07-13
Release date:2017-12-13
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
J. Med. Chem., 60, 2017
6JLS
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CRYSTAL STRUCTURE OF FMN-DEPENDENT CYSTEINE DECARBOXYLASES TVAF FROM THIOVIRIDAMIDE BIOSYNTHESIS
Descriptor:Putative flavoprotein decarboxylase, FLAVIN MONONUCLEOTIDE
Authors:Li, J., Lu, J., Wang, H., Zhu, J.
Deposit date:2019-03-06
Release date:2019-06-26
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Characterization of the FMN-Dependent Cysteine Decarboxylase from Thioviridamide Biosynthesis.
Org.Lett., 21, 2019
2VC2
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST L-739758
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-09-18
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDK
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDL
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDM
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDN
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RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST EPTIFIBATIDE
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, EPTIFIBATIDE, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDO
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQAGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDP
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO FIBRINOGEN GAMMA CHAIN PEPTIDE,LGGAKQAGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDQ
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, HHLGGAKQRGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
2VDR
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INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO A CHIMERIC FIBRINOGEN GAMMA CHAIN PEPTIDE, LGGAKQRGDV
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, FIBRINOGEN, ...
Authors:Springer, T.A., Zhu, J., Xiao, T.
Deposit date:2007-10-10
Release date:2008-09-02
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182, 2008
3DBC
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CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND 257
Descriptor:Polo-like kinase 1, 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
Authors:Elling, R.A., Zhu, J., Barr, K.J., Romanowski, M.J.
Deposit date:2008-05-31
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
3DBF
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CRYSTAL STRUCTURE OF AN ACTIVATED (THR->ASP) POLO-LIKE KINASE 1 (PLK1) CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND 562
Descriptor:Polo-like kinase, 4-({1-[3-(3-amino-3-oxopropyl)-5-chlorophenyl]-3-methyl-1H-pyrazolo[4,3-c]pyridin-6-yl}amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
Authors:Elling, R.A., Zhu, J., Barr, K.J., Romanowski, M.J.
Deposit date:2008-05-31
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
3H3B
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CRYSTAL STRUCTURE OF THE SINGLE-CHAIN FV (SCFV) FRAGMENT OF AN ANTI-ERBB2 ANTIBODY CHA21 IN COMPLEX WITH RESIDUES 1-192 OF ERBB2 EXTRACELLULAR DOMAIN
Descriptor:Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21
Authors:Zhou, H., Liu, Y., Niu, L., Zhu, J., Teng, M.
Deposit date:2009-04-16
Release date:2010-04-28
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21.
J.Biol.Chem., 286, 2011
3K6S
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STRUCTURE OF INTEGRIN ALPHAXBETA2 ECTODOMAIN
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-09
Release date:2010-01-12
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3K71
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STRUCTURE OF INTEGRIN ALPHAX BETA2 ECTODOMAIN
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-11
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3K72
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STRUCTURE OF INTEGRIN ALPHAX BETA2
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-11
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3MME
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STRUCTURE AND FUNCTIONAL DISSECTION OF PG16, AN ANTIBODY WITH BROAD AND POTENT NEUTRALIZATION OF HIV-1
Descriptor:PG16 HEAVY CHAIN FAB, PG16 LIGHT CHAIN FAB, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Pancera, M., McLellan, J., Zhou, T., Zhu, J., Kwong, P.
Deposit date:2010-04-19
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.97 Å)
Cite:Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
J.Virol., 84, 2010