Author results

3JTY
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CRYSTAL STRUCTURE OF A BENF-LIKE PORIN FROM PSEUDOMONAS FLUORESCENS PF-5
Descriptor:BenF-like porin, LAURYL DIMETHYLAMINE-N-OXIDE
Authors:Sampathkumar, P., Lu, F., Zhao, X., Wasserman, S., Iuzuka, M., Bain, K., Rutter, M., Gheyi, T., Atwell, S., Luz, J., Gilmore, J., Sauder, J.M., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2009-09-14
Release date:2009-10-20
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure of a putative BenF-like porin from Pseudomonas fluorescens Pf-5 at 2.6 A resolution.
Proteins, 78, 2010
3KO2
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I-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY (-7C)
Descriptor:Site-specific DNA endonuclease I-MsoI, 5'-D(*GP*CP*AP*GP*AP*CP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*GP*TP*CP*TP*GP*C)-3', ...
Authors:Taylor, G.K., Stoddard, B.L.
Deposit date:2009-11-13
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
3LEF
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_S0_1Z6NA_001
Descriptor:Uncharacterized protein 4E10_S0_1Z6NA_001 (T18), 1,2-ETHANEDIOL
Authors:Holmes, M.A.
Deposit date:2010-01-14
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LF6
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_1XIZA_S0_001_N
Descriptor:Putative phosphotransferase system, PHOSPHATE ION
Authors:Holmes, M.A.
Deposit date:2010-01-15
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LF9
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_D0_1IS1A_001_C
Descriptor:4E10_D0_1IS1A_001_C (T161)
Authors:Holmes, M.A.
Deposit date:2010-01-16
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LG7
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_S0_1EZ3A_002_C
Descriptor:4E10_S0_1EZ3A_002_C (T246), SULFATE ION
Authors:Holmes, M.A.
Deposit date:2010-01-19
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LH2
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_1VI7A_S0_002_N 4E10 FV COMPLEX
Descriptor:4E10_1VI7A_S0_002_N (T88), Fv 4E10 heavy chain, Fv 4E10 light chain
Authors:Holmes, M.A.
Deposit date:2010-01-21
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LHP
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CRYSTAL STRUCTURE OF HIV EPITOPE-SCAFFOLD 4E10_D0_1ISEA_004_N 4E10 FV COMPLEX
Descriptor:Fv 4E10 heavy chain, Fv 4E10 light chain, 4E10_D0_1ISEA_004_N (T93), ...
Authors:Holmes, M.A.
Deposit date:2010-01-22
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3MIP
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I-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY (-8GCG)
Descriptor:Mso-8G, DNA (5'-D(*GP*CP*AP*GP*GP*CP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*GP*CP*CP*TP*GP*C)-3'), ...
Authors:Taylor, G.K., Stoddard, B.L.
Deposit date:2010-04-11
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
3MIS
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I-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY (-8G)
Descriptor:Mso-8G, DNA (5'-D(*GP*CP*AP*GP*GP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*CP*CP*TP*GP*C)-3'), ...
Authors:Taylor, G.K., Stoddard, B.L.
Deposit date:2010-04-12
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
3QA9
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CRYSTAL STRUCTURE OF PRB (PH1109 PROTEIN REDESIGNED FOR BINDING)
Descriptor:CoA binding domain protein
Authors:Spiegel, P.C.
Deposit date:2011-01-10
Release date:2011-04-20
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A de novo protein binding pair by computational design and directed evolution.
Mol.Cell, 42, 2011
3R2X
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CRYSTAL STRUCTURE OF THE DE NOVO DESIGNED BINDING PROTEIN HB36.3 IN COMPLEX THE THE 1918 INFLUENZA VIRUS HEMAGGLUTININ
Descriptor:Hemagglutinin, HB36.3, designed hemagglutinin binding protein, ...
Authors:Ekiert, D.C., Wilson, I.A.
Deposit date:2011-03-14
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Computational design of proteins targeting the conserved stem region of influenza hemagglutinin.
Science, 332, 2011
3RPT
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CRYSTAL STRUCTURE OF THE ANTI-HIV B12 SCAFFOLD PROTEIN
Descriptor:Endoglucanase E-2, SULFATE ION
Authors:Chen, L., Kwong, P.D.
Deposit date:2011-04-27
Release date:2011-12-21
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.303 Å)
Cite:Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
Science, 334, 2011
3RU8
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STRUCTURE OF AN HIV EPITOPE SCAFFOLD IN COMPLEX WITH NEUTRALIZING ANTIBODY B12 FAB
Descriptor:Epitope Scaffold 2bodx43, Antibody b12, Heavy Chain, ...
Authors:Carrico, C.T.D., Strong, R.K.
Deposit date:2011-05-04
Release date:2011-11-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
Science, 334, 2011
3T1G
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ENGINEERING OF ORGANOPHOSPHATE HYDROLASE BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION
Descriptor:organophosphate hydrolase, ZINC ION, CALCIUM ION
Authors:Takeuchi, R., Stoddard, B.L.
Deposit date:2011-07-21
Release date:2012-02-08
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Nat.Chem.Biol., 8, 2012
3U26
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CRYSTAL STRUCTURE OF ENGINEERED PROTEIN. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET OR48
Descriptor:PF00702 domain protein
Authors:Seetharaman, J., Lew, S., Nivon, L., Baker, D., Bjelic, S., Ciccosanti, C., Sahdev, S., Xiao, R., Everett, J.K., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2011-09-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR48
To be Published
3U43
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CRYSTAL STRUCTURE OF THE COLICIN E2 DNASE-IM2 COMPLEX
Descriptor:Colicin-E2 immunity protein, Colicin-E2, ZINC ION, ...
Authors:Wojdyla, J.A., Kleanthous, C.
Deposit date:2011-10-07
Release date:2012-03-21
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structure of the Ultra-High-Affinity Colicin E2 DNase-Im2 Complex.
J.Mol.Biol., 417, 2012
4EEF
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CRYSTAL STRUCTURE OF THE DESIGNED INHIBITOR PROTEIN F-HB80.4 IN COMPLEX WITH THE 1918 INFLUENZA VIRUS HEMAGGLUTININ.
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, F-HB80.4, ...
Authors:Dreyfus, C., Wilson, I.A.
Deposit date:2012-03-28
Release date:2012-06-27
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing.
Nat.Biotechnol., 30, 2012
4F2V
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED SERINE HYDROLASE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR165
Descriptor:De novo designed serine hydrolase, DODECYL-ALPHA-D-MALTOSIDE, DI(HYDROXYETHYL)ETHER
Authors:Kuzin, A., Lew, S., Seetharaman, J., Maglaqui, M., Xiao, R., Kohan, E., Rajagopalan, S., Everett, J.K., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-05-08
Release date:2012-05-30
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
4G08
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CRYSTAL STRUCTURE OF THE PERIPLASMIC DOMAIN OF INVG
Descriptor:Protein InvG
Authors:Bergeron, J.R.C., Strynadka, N.C.J.
Deposit date:2012-07-09
Release date:2013-05-08
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
Plos Pathog., 9, 2013
4G1I
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STRUCTURE OF THE PRGH PERIPLASMIC DOMAIN
Descriptor:Protein prgH, PENTAETHYLENE GLYCOL, PHOSPHATE ION
Authors:Bergeron, J.R.C., Worrall, L.J., Strynadka, N.C.J.
Deposit date:2012-07-10
Release date:2013-05-08
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
Plos Pathog., 9, 2013
4G2S
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CRYSTAL STRUCTURE OF A SALMONELLA TYPE III SECRETION SYSTEM PROTEIN
Descriptor:Protein prgH, CALCIUM ION
Authors:Worrall, L.J., Vuckovic, M., Strynadka, N.C.J.
Deposit date:2012-07-12
Release date:2013-05-15
Method:X-RAY DIFFRACTION (1.858 Å)
Cite:A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly.
Plos Pathog., 9, 2013
4J3O
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CRYSTAL STRUCTURE OF THE FIMD USHER TRAVERSED BY THE PILUS TIP COMPLEX ASSEMBLY COMPOSED OF FIMC:FIMF:FIMG:FIMH
Descriptor:Protein FimG, Protein FimH, Chaperone protein FimC, ...
Authors:Geibel, S., Waksman, G.
Deposit date:2013-02-06
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural and energetic basis of folded-protein transport by the FimD usher.
Nature, 496, 2013
4J8T
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ENGINEERED DIGOXIGENIN BINDER DIG10.2
Descriptor:Engineered Digoxigenin binder protein DIG10.2, DIGOXIGENIN
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2013-02-14
Release date:2013-06-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Computational design of ligand-binding proteins with high affinity and selectivity.
Nature, 501, 2013
4J9A
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ENGINEERED DIGOXIGENIN BINDER DIG10.3
Descriptor:Engineered Digoxigenin binder protein DIG10.3, DIGOXIGENIN
Authors:Stoddard, B.L., Doyle, L.A.
Deposit date:2013-02-15
Release date:2013-06-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Computational design of ligand-binding proteins with high affinity and selectivity.
Nature, 501, 2013