8SUE
| Human asparagine synthetase (apo-ASNS) | Descriptor: | Asparagine synthetase [glutamine-hydrolyzing] | Authors: | Coricello, A, Zhu, W, Lupia, A, Gratteri, C, Vos, M, Chaptal, V, Alcaro, S, Takagi, Y, Richards, N. | Deposit date: | 2023-05-12 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Human asparagine synthetase (apo-ASNS) To Be Published
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6GQ3
| Human asparagine synthetase (ASNS) in complex with 6-diazo-5-oxo-L-norleucine (DON) at 1.85 A resolution | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-OXO-L-NORLEUCINE, ... | Authors: | Zhu, W, Radadiya, A, Bisson, C, Jin, Y, Nordin, B.E, Imasaki, T, Wenzel, S, Sedelnikova, S.E, Berry, A.H, Nomanbhoy, T.K, Kozarich, J.W, Takagi, Y, Rice, D.W, Richards, N.G.J. | Deposit date: | 2018-06-07 | Release date: | 2019-09-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity. Commun Biol, 2, 2019
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2PW6
| Crystal structure of uncharacterized protein JW3007 from Escherichia coli K12 | Descriptor: | Uncharacterized protein ygiD, ZINC ION | Authors: | Newton, M.G, Takagi, Y, Ebihara, A, Shinkai, A, Kuramitsu, S, Yokayama, S, Li, Y, Chen, L, Zhu, J, Ruble, J, Liu, Z.J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-10 | Release date: | 2007-06-12 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Crystal structure of uncharacterized protein JW3007 from Escherichia coli K12. To be Published
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7ROZ
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7RQS
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6OBI
| Remarkable rigidity of the single alpha-helical domain of myosin-VI revealed by NMR spectroscopy | Descriptor: | Myosin-VI | Authors: | Barnes, A, Shen, Y, Ying, J, Takagi, Y, Torchia, D.A, Sellers, J, Bax, A. | Deposit date: | 2019-03-20 | Release date: | 2019-06-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Remarkable Rigidity of the Single alpha-Helical Domain of Myosin-VI As Revealed by NMR Spectroscopy. J.Am.Chem.Soc., 141, 2019
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4YTK
| Structure of the KOW1-Linker1 domain of Transcription Elongation Factor Spt5 | Descriptor: | Transcription elongation factor SPT5 | Authors: | Meyer, P.A, Li, S, Zhang, M, Yamada, K, Takagi, Y, Hartzog, G.A, Fu, J. | Deposit date: | 2015-03-17 | Release date: | 2015-08-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.0904 Å) | Cite: | Structures and Functions of the Multiple KOW Domains of Transcription Elongation Factor Spt5. Mol.Cell.Biol., 35, 2015
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4YTL
| Structure of the KOW2-KOW3 Domain of Transcription Elongation Factor Spt5. | Descriptor: | GLYCEROL, SULFATE ION, Transcription elongation factor SPT5 | Authors: | Meyer, P.A, Li, S, ZHang, M, Yamada, K, Takagi, Y, Hartzog, G.A, Fu, J. | Deposit date: | 2015-03-17 | Release date: | 2015-08-12 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Structures and Functions of the Multiple KOW Domains of Transcription Elongation Factor Spt5. Mol.Cell.Biol., 35, 2015
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3RJ1
| Architecture of the Mediator Head module | Descriptor: | Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, Mediator of RNA polymerase II transcription subunit 18, ... | Authors: | Imasaki, T, Calero, G, Cai, G, Tsai, K.L, Yamada, K, Cardelli, F, Erdjument-Bromage, H, Tempst, P, Berger, I, Kornberg, G.L, Asturias, F.J, Kornberg, R.D, Takagi, Y. | Deposit date: | 2011-04-14 | Release date: | 2011-07-27 | Last modified: | 2017-08-02 | Method: | X-RAY DIFFRACTION (4.3 Å) | Cite: | Architecture of the Mediator head module. Nature, 475, 2011
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6L7V
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6L7X
| Crystal structure of Cet1 from Trypanosoma cruzi in complex with #951 ligand | Descriptor: | 1,3-dimethyl-7-propyl-purine-2,6-dione, SULFATE ION, mRNA_triPase domain-containing protein | Authors: | Kuwabara, N, Ho, K. | Deposit date: | 2019-11-03 | Release date: | 2020-06-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Crystal structures of the RNA triphosphatase fromTrypanosoma cruziprovide insights into how it recognizes the 5'-end of the RNA substrate. J.Biol.Chem., 295, 2020
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6L7W
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6L7Y
| Crystal structure of Cet1 from Trypanosoma cruzi in complex with #466 ligand. | Descriptor: | 3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione, SULFATE ION, mRNA_triPase domain-containing protein | Authors: | Kuwabara, N, Ho, K. | Deposit date: | 2019-11-03 | Release date: | 2020-06-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Crystal structures of the RNA triphosphatase fromTrypanosoma cruziprovide insights into how it recognizes the 5'-end of the RNA substrate. J.Biol.Chem., 295, 2020
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5WU1
| Crystal structure of apo human Tut1, form I | Descriptor: | CHLORIDE ION, Speckle targeted PIP5K1A-regulated poly(A) polymerase | Authors: | Yamashita, S, Tomita, K. | Deposit date: | 2016-12-16 | Release date: | 2017-05-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of U6 snRNA-specific terminal uridylyltransferase Nat Commun, 8, 2017
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6XAF
| 1.9A crystal structure of the GTPase domain of Parkinson's disease-associated protein LRRK2 carrying R1398H | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION | Authors: | Hoang, Q.Q, Liao, J, Huang, X, Park, Y, Wu, C.X. | Deposit date: | 2020-06-04 | Release date: | 2021-06-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.968 Å) | Cite: | Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2 To be Published
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6SWT
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7F2X
| Crystal structure of MEK1 C121S mutant | Descriptor: | MEK1 F11, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Fujioka, Y, Noda, N.N. | Deposit date: | 2021-06-15 | Release date: | 2022-06-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.007 Å) | Cite: | Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer. Nat Commun, 13, 2022
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3L85
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6OJE
| Dimeric structure of LRRK2 GTPase domain | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION | Authors: | Hoang, Q.Q, Wu, C.X, Liao, J, Park, Y. | Deposit date: | 2019-04-11 | Release date: | 2020-10-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2 To Be Published
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6OJF
| Dimeric structure of LRRK2 GTPase domain | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION | Authors: | Hoang, Q.Q, Wu, C.X, Liao, J, Park, Y. | Deposit date: | 2019-04-11 | Release date: | 2020-10-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2 To be published
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3J1O
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3J1N
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5WU4
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5WU3
| Crystal structure of human Tut1 bound with MgUTP, form II | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Yamashita, S, Tomita, K. | Deposit date: | 2016-12-16 | Release date: | 2017-05-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.703 Å) | Cite: | Crystal structures of U6 snRNA-specific terminal uridylyltransferase Nat Commun, 8, 2017
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3OLR
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