6XAF
1.9A crystal structure of the GTPase domain of Parkinson's disease-associated protein LRRK2 carrying R1398H
Summary for 6XAF
Entry DOI | 10.2210/pdb6xaf/pdb |
Descriptor | Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | parkinson's disease, lrrk2, gtpase, dimer, interswitch, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 47686.79 |
Authors | Hoang, Q.Q.,Liao, J.,Huang, X.,Park, Y.,Wu, C.X. (deposition date: 2020-06-04, release date: 2021-06-09, Last modification date: 2023-10-18) |
Primary citation | Wu, C.X.,Liao, J.,Park, Y.,Hoang, N.C.,Engel, V.A.,Sanishvili, R.,Takagi, Y.,Johnson, S.M.,Wang, M.,Federici, M.,Nichols, R.J.,Cookson, M.R.,Hoang, Q.Q. Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2 To be Published, |
Experimental method | X-RAY DIFFRACTION (1.968 Å) |
Structure validation
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