6XAF

1.9A crystal structure of the GTPase domain of Parkinson's disease-associated protein LRRK2 carrying R1398H

Summary for 6XAF

• Entry DOI: 10.2210/pdb6xaf/pdb
• Descriptor: Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: parkinson's disease, lrrk2, gtpase, dimer, interswitch, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 47686.79

Authors

Hoang, Q.Q.,Liao, J.,Huang, X.,Park, Y.,Wu, C.X. (deposition date: 2020-06-04, release date: 2021-06-09, Last modification date: 2023-10-18)

• Primary citation: Wu, C.X.,Liao, J.,Park, Y.,Hoang, N.C.,Engel, V.A.,Sanishvili, R.,Takagi, Y.,Johnson, S.M.,Wang, M.,Federici, M.,Nichols, R.J.,Cookson, M.R.,Hoang, Q.Q.; Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2; To be Published,

Experimental method

X-RAY DIFFRACTION (1.968 Å)