6XAF

1.9A crystal structure of the GTPase domain of Parkinson's disease-associated protein LRRK2 carrying R1398H

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Leucine-rich repeat serine/threonine-protein kinase 2	polymer	206	23375.9	2	UniProt (Q5S007) Pfam (PF08477)	Homo sapiens (Human)	Dardarin
2	C, E (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D, F (A, B)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
4	G, H (A, B)	water	water		18.0	134	Chemie (HOH)

Sequence modifications

A, B: 1329 - 1520 (UniProt: Q5S007)

PDB	External Database	Details
Met 1315	-	expression tag
Gly 1316	-	expression tag
Ser 1317	-	expression tag
Ser 1318	-	expression tag
His 1319	-	expression tag
His 1320	-	expression tag
His 1321	-	expression tag
His 1322	-	expression tag
His 1323	-	expression tag
His 1324	-	expression tag
Ser 1325	-	expression tag
Gln 1326	-	expression tag
Asp 1327	-	expression tag
Pro 1328	-	expression tag
His 1398	Arg 1398	engineered mutation
Ala 1460	Lys 1460	engineered mutation
Ala 1463	Lys 1463	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	46751.8
Non-Polymers*	Number of molecules	4
	Total formula weight	935.0
All*	Total formula weight	47686.8

*Water molecules are not included.