7F2X

Crystal structure of MEK1 C121S mutant

Summary for 7F2X

• Entry DOI: 10.2210/pdb7f2x/pdb
• Descriptor: MEK1 F11, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
• Functional Keywords: kinase, signaling protein
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 36219.26

Authors

Fujioka, Y.,Noda, N.N. (deposition date: 2021-06-15, release date: 2022-06-22, Last modification date: 2023-11-29)

• Primary citation: Kubota, Y.,Fujioka, Y.,Patil, A.,Takagi, Y.,Matsubara, D.,Iijima, M.,Momose, I.,Naka, R.,Nakai, K.,Noda, N.N.,Takekawa, M.; Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.; Nat Commun, 13:4063-4063, 2022; PubMed: 35831322; DOI: 10.1038/s41467-022-31690-w

Experimental method

X-RAY DIFFRACTION (2.007 Å)