6OJF

Dimeric structure of LRRK2 GTPase domain

Summary for 6OJF

• Entry DOI: 10.2210/pdb6ojf/pdb
• Descriptor: Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: parkinson's disease, lrrk2, gtpase, dimer, interswitch, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 47773.49

Authors

Hoang, Q.Q.,Wu, C.X.,Liao, J.,Park, Y. (deposition date: 2019-04-11, release date: 2020-10-14, Last modification date: 2023-10-11)

• Primary citation: Wu, C.X.,Liao, J.,Park, Y.,Hoang, N.C.,Engel, V.A.,Sanishvili, R.,Takagi, Y.,Johnson, S.M.,Wang, M.,Federici, M.,Nichols, R.J.,Cookson, M.R.,Hoang, Q.Q.; Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2; To be published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)