6OJF

Dimeric structure of LRRK2 GTPase domain

Summary for 6OJF

• Entry DOI: 10.2210/pdb6ojf/pdb
• Descriptor: Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: parkinson's disease, lrrk2, gtpase, dimer, interswitch, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 47773.49

Authors

Hoang, Q.Q.,Wu, C.X.,Liao, J.,Park, Y. (deposition date: 2019-04-11, release date: 2020-10-14, Last modification date: 2026-04-22)

• Primary citation: Park, Y.,Wu, C.,Tennessen, K.,Wan, L.,Hoang, N.C.,Hoang, C.W.,Liao, J.,Hoang, Q.Q.; Structural and biochemical basis of ROC-dependent activation of LRRK2; Pnas Nexus, 2026; DOI: 10.1093/pnasnexus/pgag112

Experimental method

X-RAY DIFFRACTION (1.6 Å)