Author results

1MT7
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VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE MUTANT: STRUCTURAL INSIGHTS FOR BETTER ANTIVIRAL THERAPY
分子名称:PROTEASE RETROPEPSIN, Substrate analogue, ACETATE ION
著者Prabu-Jeyabalan, M., Nalivaika, E.A., King, N.M., Schiffer, C.A.
登録日2002-09-20
公開日2003-01-07
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Viability of drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy
J.Virol., 77, 2003
1MT8
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VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE MUTANT: STRUCTURAL INSIGHTS FOR BETTER ANTIVIRAL THERAPY
分子名称:PROTEASE RETROPEPSIN, Capsid-p2 substrate peptide of HIV-1 Gag polyprotein, ACETATE ION
著者Prabu-Jeyabalan, M., Nalivaika, E.A., King, N.M., Schiffer, C.A.
登録日2002-09-20
公開日2003-01-07
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Viability of drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy
J.Virol., 77, 2003
1MT9
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VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE MUTANT: STRUCTURAL INSIGHTS FOR BETTER ANTIVIRAL THERAPY
分子名称:PROTEASE RETROPEPSIN, p1-p6 Gag substrate decapeptide, PHOSPHATE ION
著者Prabu-Jeyabalan, M., Nalivaika, E.A., King, N.M., Schiffer, C.A.
登録日2002-09-20
公開日2003-01-07
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Viability of drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy
J.Virol., 77, 2003
1MTB
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VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE MUTANT: STRUCTURAL INSIGHTS FOR BETTER ANTIVIRAL THERAPY
分子名称:PROTEASE RETROPEPSIN, quinoline-2-carboxylic acid, ASPARAGINE, ...
著者Prabu-Jeyabalan, M., Nalivaika, E.A., King, N.M., Schiffer, C.A.
登録日2002-09-20
公開日2003-01-07
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Viability of drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy
J.Virol., 77, 2003
1N49
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VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE VARIANT: STRUCTURAL INSIGHTS FOR BETTER ANTI-VIRAL THERAPY
分子名称:Protease, RITONAVIR
著者Prabu-Jeyabalan, M., Nalivaika, E.A., King, N.M., Schiffer, C.A.
登録日2002-10-30
公開日2003-01-07
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights for Better Antiviral Therapy
J.VIROL., 77, 2003
2FNS
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CRYSTAL STRUCTURE OF WILD-TYPE INACTIVE (D25N) HIV-1 PROTEASE COMPLEXED WITH WILD-TYPE HIV-1 NC-P1 SUBSTRATE.
分子名称:Protease, NC-P1 SUBSTRATE PEPTIDE, ACETATE ION, ...
著者Prabu-Jeyabalan, M., Nalivaika, E.A., Schiffer, C.A.
登録日2006-01-11
公開日2006-09-05
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.
J.Virol., 80, 2006
2FNT
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CRYSTAL STRUCTURE OF A DRUG-RESISTANT (V82A) INACTIVE (D25N) HIV-1 PROTEASE COMPLEXED WITH AP2V VARIANT OF HIV-1 NC-P1 SUBSTRATE.
分子名称:protease, NC-p1 substrate PEPTIDE, ACETATE ION, ...
著者Prabu-Jeyabaln, M., Nalivaika, E.A., Schiffer, C.A.
登録日2006-01-11
公開日2006-09-05
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.
J.Virol., 80, 2006
1TSQ
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CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT
分子名称:Pol polyprotein, AP2V NC-P1 SUBSTRATE PEPTIDE, ACETATE ION
著者Prabu-Jeyabalan, M., Nalivaika, E.A., King, N.M., Schiffer, C.A.
登録日2004-06-21
公開日2005-03-29
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease
J.Virol., 78, 2004
1TSU
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CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT
分子名称:Pol polyprotein, NC-P1 SUBSTRATE PEPTIDE
著者Prabu-Jeyabalan, M., Nalivaika, E.A., King, N.M., Schiffer, C.A.
登録日2004-06-21
公開日2005-03-29
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease
J.Virol., 78, 2004
2F3K
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SUBSTRATE ENVELOPE AND DRUG RESISTANCE: CRYSTAL STRUCTURE OF R01 IN COMPLEX WITH WILD-TYPE HIV-1 PROTEASE
分子名称:Protease, PHOSPHATE ION, (3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE
著者Prabu-Jeyabalan, M., King, N.M., Nalivaika, E.A., Heilek-Snyder, G., Cammack, N., Schiffer, C.A.
登録日2005-11-21
公開日2006-11-21
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.
Antimicrob.Agents Chemother., 50, 2006
3EM6
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CRYSTAL STRUCTURE OF I50L/A71V MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR DARUNAVIR
分子名称:Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ...
著者Royer, C.J., King, N.M., Prabu-Jeyabalan, M., Ng, C., Nalivaika, E.A., Schiffer, C.A.
登録日2008-09-23
公開日2009-09-01
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Kinetic and structural studies on atazanavir specific I50L drug-resistant HIV-1 protease mutant.
To be Published
3OY4
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CRYSTAL STRUCTURE OF HIV-1 L76V PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR DARUNAVIR.
分子名称:HIV-1 PROTEASE, PHOSPHATE ION, ACETATE ION, ...
著者Schiffer, C.A., Nalivaika, E.A., Bandaranayake, R.M.
登録日2010-09-22
公開日2011-02-09
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
To be Published
4Q1W
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MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE
分子名称:ASPARTYL PROTEASE, PHOSPHATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ...
著者Ragland, D.A., Nalam, M.N.L., Cao, H., Nalivaika, E.A., Cai, Y., Kurt-Yilmaz, N., Schiffer, C.A.
登録日2014-04-04
公開日2015-02-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
J.Am.Chem.Soc., 136, 2014
4Q1X
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MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE
分子名称:ASPARTYL PROTEASE, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, GLYCEROL, ...
著者Ragland, D.A., Nalam, M.N.L., Cao, H., Nalivaika, E.A., Cai, Y., Kurt-Yilmaz, N., Schiffer, C.A.
登録日2014-04-04
公開日2015-02-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
J.Am.Chem.Soc., 136, 2014
4Q1Y
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MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE
分子名称:aspartyl protease, PHOSPHATE ION, ACETATE ION, ...
著者Ragland, D.A., Nalam, M.N.L., Cao, H., Nalivaika, E.A., Cai, Y., Kurt-Yilmaz, N., Schiffer, C.A.
登録日2014-04-04
公開日2015-02-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
J.Am.Chem.Soc., 136, 2014
6OOS
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HIV-1 PROTEASE NL4-3 L90M MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:NL4-3 PROTEASE, SULFATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Henes, M., Kosovrasti, K., Lockbaum, G.J., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A., Whitfield, T.W.
登録日2019-04-23
公開日2019-08-21
最終更新日2019-09-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Biochemistry, 58, 2019
6OOT
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HIV-1 PROTEASE NL4-3 L89V, L90M MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:NL4-3 PROTEASE, SULFATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Henes, M., Kosovrasti, K., Lockbaum, G.J., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A., Whitfield, T.W.
登録日2019-04-23
公開日2019-08-21
最終更新日2019-09-11
実験手法X-RAY DIFFRACTION (1.822 Å)
主引用文献Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Biochemistry, 58, 2019
6OOU
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 L89V MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:NL4-3 PROTEASE, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SULFATE ION
著者Henes, M., Kosovrasti, K., Lockbaum, G.J., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A., Whitfield, T.W.
登録日2019-04-23
公開日2019-08-21
最終更新日2019-09-11
実験手法X-RAY DIFFRACTION (2.127 Å)
主引用文献Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
Biochemistry, 58, 2019
6OPS
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HIV-1 PROTEASE NL4-3 WT IN COMPLEX WITH DARUNAVIR
分子名称:Protease NL4-3, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Lockbaum, G.J., Henes, M., Kosovrasti, K., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A.
登録日2019-04-25
公開日2019-09-04
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Acs Chem.Biol., 2019
6OPT
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HIV-1 PROTEASE NL4-3 V82F, I84V MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:Protease NL4-3, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SULFATE ION
著者Lockbaum, G.J., Henes, M., Kosovrasti, K., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A.
登録日2019-04-25
公開日2019-09-04
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Acs Chem.Biol., 2019
6OPU
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HIV-1 PROTEASE NL4-3 K45I, M46I, V82F, I84V MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:Protease NL4-3, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Lockbaum, G.J., Henes, M., Kosovrasti, K., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A.
登録日2019-04-25
公開日2019-09-04
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Acs Chem.Biol., 2019
6OPV
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HIV-1 PROTEASE NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, V82F, I84V MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:Protease NL4-3, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Lockbaum, G.J., Henes, M., Kosovrasti, K., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A.
登録日2019-04-25
公開日2019-09-04
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Acs Chem.Biol., 2019
6OPW
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HIV-1 PROTEASE NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, V82F, I84V MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:Protease NL4-3, SULFATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Lockbaum, G.J., Henes, M., Kosovrasti, K., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A.
登録日2019-04-25
公開日2019-09-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Acs Chem.Biol., 2019
6OPX
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HIV-1 PROTEASE NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, L76V, V82F, I84V MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:Protease NL4-3, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Lockbaum, G.J., Henes, M., Kosovrasti, K., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A.
登録日2019-04-25
公開日2019-09-04
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Acs Chem.Biol., 2019
6OPY
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HIV-1 PROTEASE NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, L76V, V82F, I84V MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:Protease NL4-3, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Lockbaum, G.J., Henes, M., Kosovrasti, K., Leidner, F., Nachum, G.S., Nalivaika, E.A., Bolon, D.N.A., KurtYilmaz, N., Schiffer, C.A.
登録日2019-04-25
公開日2019-09-04
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
Acs Chem.Biol., 2019