2F3K

Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease

Summary for 2F3K

• Entry DOI: 10.2210/pdb2f3k/pdb
• Descriptor: Protease, PHOSPHATE ION, (3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE, ... (4 entities in total)
• Functional Keywords: substrate envelope, drug resistance, hiv protease, ro1, hydrolase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 2
• Total formula weight: 22818.35

Authors

Prabu-Jeyabalan, M.,King, N.M.,Nalivaika, E.A.,Heilek-Snyder, G.,Cammack, N.,Schiffer, C.A. (deposition date: 2005-11-21, release date: 2006-11-21, Last modification date: 2023-08-23)

• Primary citation: Prabu-Jeyabalan, M.,King, N.M.,Nalivaika, E.A.,Heilek-Snyder, G.,Cammack, N.,Schiffer, C.A.; Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease.; Antimicrob.Agents Chemother., 50:1518-1521, 2006; PubMed: 16569872; DOI: 10.1128/AAC.50.4.1518-1521.2006

Experimental method

X-RAY DIFFRACTION (1.599 Å)