2F3K
Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10815.8 | 2 | UniProt (P03369) Pfam (PF00077) UniProt (by SIFTS) (O38708) | Human immunodeficiency virus 1 | Retropepsin, PR |
| 2 | C, D, E, G, H (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 3 | F (A) | (3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE | non-polymer | 711.9 | 1 | Chemie (RO1) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 206 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 496 | engineered mutation |
| Ile 64 | Val 553 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21631.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1186.8 | |
| All* | Total formula weight | 22818.3 |
