Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 501 |
| Chain | Residue |
| A | ARG14 |
| B | HOH550 |
| A | ILE15 |
| A | GLY16 |
| A | GLY17 |
| A | HOH548 |
| B | ARG14 |
| B | ILE15 |
| B | GLY16 |
| B | HOH531 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 502 |
| Chain | Residue |
| A | LYS7 |
| A | ARG8 |
| A | HOH568 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 503 |
| Chain | Residue |
| A | GLY68 |
| A | HIS69 |
| A | LYS70 |
| A | HOH564 |
| B | PRO1 |
| B | LYS55 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 504 |
| Chain | Residue |
| A | MET36 |
| A | ASN37 |
| A | HOH593 |
| A | HOH608 |
| B | PRO39 |
| B | GLY40 |
| B | HOH548 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 505 |
| Chain | Residue |
| A | LYS20 |
| A | GLU21 |
| A | ASN83 |
| A | HOH528 |
| A | HOH599 |
| A | HOH609 |
| site_id | AC6 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE RO1 A 506 |
| Chain | Residue |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | VAL32 |
| A | ILE47 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| A | THR80 |
| A | PRO81 |
| A | VAL82 |
| A | ILE84 |
| A | HOH507 |
| A | HOH508 |
| A | HOH509 |
| A | HOH510 |
| A | HOH511 |
| A | HOH527 |
| B | TRP6 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | VAL32 |
| B | ILE47 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | THR80 |
| B | PRO81 |
| B | VAL82 |
| B | ILE84 |
| B | HOH510 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| Chain | Residue | Details |
| A | ALA22-LEU33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| B | ASP25 | |
| B | THR26 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP25 | |
