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1MT8

Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy

Summary for 1MT8
Entry DOI10.2210/pdb1mt8/pdb
Related1KJ4 1MT7 1MT9 1MTB 1MTR
DescriptorPROTEASE RETROPEPSIN, Capsid-p2 substrate peptide of HIV-1 Gag polyprotein, ACETATE ION, ... (4 entities in total)
Functional Keywordsmatrix, capsid, gag cleavage, drug resistance, substrate recognition, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
Total number of polymer chains3
Total formula weight22799.88
Authors
Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (deposition date: 2002-09-20, release date: 2003-01-07, Last modification date: 2024-02-14)
Primary citationPrabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.
Viability of drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy
J.Virol., 77:1305-1315, 2003
Cited by
PubMed: 12502847
DOI: 10.1128/JVI.77.2.1306-1315.2003
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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