1MT8
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | PROTEASE RETROPEPSIN | polymer | 99 | 10772.7 | 2 | UniProt (P03369) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
2 | P | Capsid-p2 substrate peptide of HIV-1 Gag polyprotein | polymer | 10 | 1077.3 | 1 | UniProt (Q9YX54) In PDB | ||
3 | B, P | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
4 | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 63 | engineered mutation |
Asn 25 | Asp 81 | engineered mutation |
Ala 82 | Val 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 22622.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 177.1 | |
All* | Total formula weight | 22799.9 |