1MT8
Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEASE RETROPEPSIN | polymer | 99 | 10772.7 | 2 | UniProt (P03369) Pfam (PF00077) | Human immunodeficiency virus 1 | HIV-1 PROTEASE |
| 2 | C (P) | Capsid-p2 substrate peptide of HIV-1 Gag polyprotein | polymer | 10 | 1077.3 | 1 | UniProt (Q9YX54) | ||
| 3 | D, E, F (B, P) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 4 | G, H, I (A, B, P) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 63 | engineered mutation |
| Asn 25 | Asp 81 | engineered mutation |
| Ala 82 | Val 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22622.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 177.1 | |
| All* | Total formula weight | 22799.9 |
