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5D2N
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BU of 5d2n by Molmil
Crystal structure of C25-NLV-HLA-A2 complex
Descriptor: ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, C25 alpha, ...
Authors:Mariuzza, R.A, Yang, X.
Deposit date:2015-08-05
Release date:2015-10-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope.
J.Biol.Chem., 290, 2015
1NDG
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BU of 1ndg by Molmil
Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme
Descriptor: ACETIC ACID, Lysozyme C, antibody kappa light chain, ...
Authors:Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J.
Deposit date:2002-12-09
Release date:2003-06-03
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray snapshots of the maturation of an antibody response to a protein antigen
Nat.Struct.Biol., 10, 2003
1NBY
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BU of 1nby by Molmil
Crystal Structure of HyHEL-63 complexed with HEL mutant K96A
Descriptor: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain
Authors:Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J.
Deposit date:2002-12-04
Release date:2003-04-01
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
1NBZ
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BU of 1nbz by Molmil
Crystal Structure of HyHEL-63 complexed with HEL mutant K97A
Descriptor: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain
Authors:Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J.
Deposit date:2002-12-04
Release date:2003-04-01
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen
Biochemistry, 42, 2003
1NDM
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BU of 1ndm by Molmil
Crystal structure of Fab fragment of antibody HyHEL-26 complexed with lysozyme
Descriptor: Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain
Authors:Mariuzza, R.A, Li, Y, Li, H.
Deposit date:2002-12-09
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray snapshots of the maturation of an antibody response to a protein antigen
Nat.Struct.Biol., 10, 2003
4XVJ
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BU of 4xvj by Molmil
STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC 2 REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HC33.1
Descriptor: HCV E2 antigen, antibody heavy chain variable domain, antibody light chain variable domain
Authors:Li, Y, Mariuzza, R.A.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for penetration of the glycan shield of hepatitis C virus e2 glycoprotein by a broadly neutralizing human antibody.
J.Biol.Chem., 290, 2015
6VQO
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BU of 6vqo by Molmil
T cell receptor-p53-HLA-A2 complex
Descriptor: Beta-2-microglobulin, MHC class I antigen, T-cell receptor 1a2, ...
Authors:Wu, D, Gallagher, D.T, Pierce, B.G, Mariuzza, R.A.
Deposit date:2020-02-05
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Nat Commun, 11, 2020
6VR1
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BU of 6vr1 by Molmil
Complex of HLA-A2, a class I MHC, with a p53 peptide
Descriptor: Beta-2-microglobulin, Cellular tumor antigen p53 peptide, MHC class I antigen
Authors:Wu, D, Pierce, B.G, Gallagher, D.T, Mariuzza, R.A.
Deposit date:2020-02-06
Release date:2020-06-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Nat Commun, 11, 2020
6VTH
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BU of 6vth by Molmil
p53-specific T cell receptor
Descriptor: SULFATE ION, T-cell Receptor 12-6, Alfa chain, ...
Authors:Wu, D, Gallagher, D.T, Gowthaman, R, Pierce, B.G, Mariuzza, R.A.
Deposit date:2020-02-12
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Nat Commun, 11, 2020
6VRN
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BU of 6vrn by Molmil
T cell receptor-p53-HLA-A2 complex
Descriptor: Beta-2-microglobulin, Cellular tumor antigen p53 peptide, MHC class I antigen, ...
Authors:Wu, D, Gallagher, D.T, Gowthaman, R, Pierce, B.G, Mariuzza, R.A.
Deposit date:2020-02-08
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Nat Commun, 11, 2020
6VTC
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BU of 6vtc by Molmil
p53-specific T cell receptor
Descriptor: T-cell Receptor 1a2, p53-specific T cell receptor, B-chain
Authors:Wu, D, Gallagher, D.T, Gowthaman, R, Pierce, B.G, Mariuzza, R.A.
Deposit date:2020-02-12
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Nat Commun, 11, 2020
6VRM
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BU of 6vrm by Molmil
T cell receptor-p53-HLA-A2 complex
Descriptor: Beta-2-microglobulin, Cellular tumor antigen p53 peptide, MHC class I antigen, ...
Authors:Wu, D, Gallagher, D.T, Gowthaman, R, Pierce, B.G, Mariuzza, R.A.
Deposit date:2020-02-08
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Nat Commun, 11, 2020
4E41
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BU of 4e41 by Molmil
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ...
Authors:Deng, L, Langley, R.J, Wang, Q, Topalian, S.L, Mariuzza, R.A.
Deposit date:2012-03-11
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Proc.Natl.Acad.Sci.USA, 2012
3L6F
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BU of 3l6f by Molmil
Structure of MHC class II molecule HLA-DR1 complexed with phosphopeptide MART-1
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ...
Authors:Li, Y, Mariuzza, R.A.
Deposit date:2009-12-23
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Presentation of Tumor-Associated MHC Class II-Restricted Phosphopeptides to CD4(+) T Cells.
J.Mol.Biol., 399, 2010
3M19
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BU of 3m19 by Molmil
Crystal structure of variable lymphocyte receptor VLRA.R5.1
Descriptor: Variable lymphocyte receptor A diversity region
Authors:Deng, L, Velikovsky, C.A, Mariuzza, R.A.
Deposit date:2010-03-04
Release date:2010-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MC0
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BU of 3mc0 by Molmil
Crystal Structure of Staphylococcal Enterotoxin G (SEG) in Complex with a Mouse T-cell Receptor beta Chain
Descriptor: ACETATE ION, Enterotoxin SEG, variable beta 8.2 mouse T cell receptor
Authors:Fernandez, M.M, Cho, S, Robinson, H, Mariuzza, R.A, Malchiodi, E.L.
Deposit date:2010-03-26
Release date:2010-10-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of staphylococcal enterotoxin G (SEG) in complex with a mouse T-cell receptor {beta} chain.
J.Biol.Chem., 286, 2011
3M18
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BU of 3m18 by Molmil
Crystal structure of variable lymphocyte receptor VLRA.R2.1 in complex with hen egg lysozyme
Descriptor: Lysozyme C, PHOSPHATE ION, Variable lymphocyte receptor A diversity region
Authors:Deng, L, Velikovsky, C.A, Mariuzza, R.A.
Deposit date:2010-03-04
Release date:2010-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey.
Proc.Natl.Acad.Sci.USA, 107, 2010
4E42
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BU of 4e42 by Molmil
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Descriptor: CHLORIDE ION, NITRATE ION, SODIUM ION, ...
Authors:Deng, L, Langley, R.J, Wang, Q, Topalian, S.L, Mariuzza, R.A.
Deposit date:2012-03-11
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Proc.Natl.Acad.Sci.USA, 2012
3T0E
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BU of 3t0e by Molmil
Crystal structure of a complete ternary complex of T cell receptor, peptide-MHC and CD4
Descriptor: HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y, Mariuzza, R.A.
Deposit date:2011-07-20
Release date:2012-03-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.
Proc.Natl.Acad.Sci.USA, 109, 2012
4Z0X
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BU of 4z0x by Molmil
Structure of Hepatitis C Virus Envelope glycoprotein E2 antigenic region 434-446 bound to the broadly neutralizing antibody HC26AM
Descriptor: Antibody HC26AM heavy chain variable domain, Antibody HC26AM light chain variable domain, HCV E2 Antigen (residues 432-446)
Authors:Rangarajan, S, Shahid, S, Mariuzza, R.A.
Deposit date:2015-03-26
Release date:2016-07-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice.
Hepatology, 64, 2016
4ZSO
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BU of 4zso by Molmil
Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ...
Authors:Xu, X, Li, Y, Mariuzza, R.A.
Deposit date:2015-05-13
Release date:2016-05-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody
to be published
2PTT
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BU of 2ptt by Molmil
Structure of NK cell receptor 2B4 (CD244) bound to its ligand CD48
Descriptor: CD48 antigen, Natural killer cell receptor 2B4, SULFATE ION
Authors:Deng, L, Velikovsky, C.A, Mariuzza, R.A.
Deposit date:2007-05-08
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.
Immunity, 27, 2007
2PTU
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BU of 2ptu by Molmil
Structure of NK cell receptor 2B4 (CD244)
Descriptor: Natural killer cell receptor 2B4
Authors:Deng, L, Velikovsky, C.A, Mariuzza, R.A.
Deposit date:2007-05-08
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.
Immunity, 27, 2007
2PTV
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BU of 2ptv by Molmil
Structure of NK cell receptor ligand CD48
Descriptor: CD48 antigen
Authors:Deng, L, Velikovsky, C.A, Mariuzza, R.A.
Deposit date:2007-05-08
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.
Immunity, 27, 2007
7K9N
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BU of 7k9n by Molmil
Co-crystal structure of alpha glucosidase with compound 2
Descriptor: (1S,2S,3R,4S,5S)-1-(hydroxymethyl)-5-[(9-methoxynonyl)amino]cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, Alpha glucosidase 2 alpha neutral subunit, ...
Authors:Karade, S.S, Mariuzza, R.A.
Deposit date:2020-09-29
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity.
J.Med.Chem., 64, 2021

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