4XVJ

STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC 2 REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HC33.1

Summary for 4XVJ

Entry DOI	10.2210/pdb4xvj/pdb
Descriptor	HCV E2 antigen, antibody heavy chain variable domain, antibody light chain variable domain, ... (4 entities in total)
Functional Keywords	antibody-antigen complex, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	28246.96
Authors	Li, Y.,Mariuzza, R.A. (deposition date: 2015-01-27, release date: 2015-03-11, Last modification date: 2016-12-28)
Primary citation	Li, Y.,Pierce, B.G.,Wang, Q.,Keck, Z.Y.,Fuerst, T.R.,Foung, S.K.,Mariuzza, R.A. Structural basis for penetration of the glycan shield of hepatitis C virus e2 glycoprotein by a broadly neutralizing human antibody. J.Biol.Chem., 290:10117-10125, 2015 Cited by PubMed: 25737449 DOI: 10.1074/jbc.M115.643528 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation