6BWD
| 3.7 angstrom cryoEM structure of truncated mouse TRPM7 | 分子名称: | CHOLESTEROL HEMISUCCINATE, MAGNESIUM ION, Transient receptor potential cation channel subfamily M member 7 | 著者 | Zhang, J, Li, Z, Duan, J, Li, J, Hulse, R.E, Santa-Cruz, A, Abiria, S.A, Krapivinsky, G, Clapham, D.E. | 登録日 | 2017-12-14 | 公開日 | 2018-08-15 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6BWM
| Crystal structure of the TRPV2 ion channel | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily V member 2 | 著者 | Zubcevic, L, Le, S, Yang, H, Lee, S.Y. | 登録日 | 2017-12-15 | 公開日 | 2018-05-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Conformational plasticity in the selectivity filter of the TRPV2 ion channel. Nat. Struct. Mol. Biol., 25, 2018
|
|
6BO5
| TRPV2 ion channel in partially closed state | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | 著者 | Dosey, T.L, Wang, Z. | 登録日 | 2017-11-18 | 公開日 | 2018-12-05 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat.Struct.Mol.Biol., 26, 2019
|
|
6V3G
| |
6BWF
| 4.1 angstrom Mg2+-unbound structure of mouse TRPM7 | 分子名称: | TRPM7 | 著者 | Zhang, J, Li, Z, Duan, J, Abiria, S.A, Clapham, D.E. | 登録日 | 2017-12-14 | 公開日 | 2018-08-15 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6UQK
| Cryo-EM structure of type 3 IP3 receptor revealing presence of a self-binding peptide | 分子名称: | ZINC ION, inositol 1,4,5-triphosphate receptor, type 3 | 著者 | Azumaya, C.M, Linton, E.A, Risener, C.J, Nakagawa, T, Karakas, E. | 登録日 | 2019-10-20 | 公開日 | 2020-01-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist. J.Biol.Chem., 295, 2020
|
|
6UZ8
| Cryo-EM structure of human TRPC6 in complex with agonist AM-0883 | 分子名称: | (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Bai, Y, Yu, X, Huang, X, Chen, H. | 登録日 | 2019-11-14 | 公開日 | 2020-03-18 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9, 2020
|
|
6V01
| |
6BPQ
| Structure of the cold- and menthol-sensing ion channel TRPM8 | 分子名称: | Transient receptor potential cation channel subfamily M member 8 | 著者 | Yin, Y, Wu, M, Zubcevic, L, Borschel, W.F, Lander, G.C, Lee, S.-Y. | 登録日 | 2017-11-25 | 公開日 | 2017-12-13 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure of the cold- and menthol-sensing ion channel TRPM8. Science, 359, 2018
|
|
6BOB
| Cryo-EM structure of rat TRPV6* in nanodiscs | 分子名称: | Transient receptor potential cation channel subfamily V member 6 | 著者 | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | 登録日 | 2017-11-18 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Opening of the human epithelial calcium channel TRPV6. Nature, 553, 2018
|
|
6UZ0
| Cardiac sodium channel with flecainide | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jiang, D, Shi, H, Tonggu, L, Lenaeus, M.J, Zheng, N, Catterall, W.A. | 登録日 | 2019-11-14 | 公開日 | 2020-01-01 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structure of the Cardiac Sodium Channel. Cell, 180, 2020
|
|
6V35
| Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Tao, X, MacKinnon, R. | 登録日 | 2019-11-25 | 公開日 | 2019-12-25 | 最終更新日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Molecular structures of the human Slo1 K + channel in complex with beta 4. Elife, 8, 2019
|
|
6BWJ
| Crystal structure of the TRPV2 ion channel in complex with RTx | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily V member 2, resiniferatoxin | 著者 | Zubcevic, L, Le, S, Yang, H, Lee, S.Y. | 登録日 | 2017-12-15 | 公開日 | 2018-05-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Conformational plasticity in the selectivity filter of the TRPV2 ion channel. Nat. Struct. Mol. Biol., 25, 2018
|
|
6V38
| Cryo-EM structure of Ca2+-bound hsSlo1 channel | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... | 著者 | Tao, X, MacKinnon, R. | 登録日 | 2019-11-25 | 公開日 | 2019-12-25 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Molecular structures of the human Slo1 K + channel in complex with beta 4. Elife, 8, 2019
|
|
6W6O
| NaChBac-Nav1.7VSDII chimera and HWTX-IV complex | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Huwentoxin-IV, NaChBac-Nav1.7VSDII chimera | 著者 | Yan, N, Gao, S. | 登録日 | 2020-03-17 | 公開日 | 2020-06-24 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na + channels in nanodisc. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6CUD
| Structure of the human TRPC3 in a lipid-occupied, closed state | 分子名称: | (2R)-3-hydroxypropane-1,2-diyl dihexanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lu, W, Du, J, Fan, C, Choi, W. | 登録日 | 2018-03-25 | 公開日 | 2018-05-16 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the human lipid-gated cation channel TRPC3. Elife, 7, 2018
|
|
8GZ1
| Cryo-EM structure of human NaV1.6/beta1/beta2,apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Sodium channel protein type 8 subunit alpha, ... | 著者 | Li, Y, Jiang, D. | 登録日 | 2022-09-24 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nat Commun, 14, 2023
|
|
8GZ2
| Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin | 分子名称: | (1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 8 subunit alpha, ... | 著者 | Li, Y, Jiang, D. | 登録日 | 2022-09-24 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nat Commun, 14, 2023
|
|
8GHF
| cryo-EM structure of hSlo1 in plasma membrane vesicles | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... | 著者 | Tao, X, Zhao, C, MacKinnon, R. | 登録日 | 2023-03-10 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Membrane protein isolation and structure determination in cell-derived membrane vesicles. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8GHG
| |
8GH9
| |
8I5B
| Structure of human Nav1.7 in complex with bupivacaine | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-24 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
8I5X
| Structure of human Nav1.7 in complex with Vinpocetine | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-26 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
8I5Y
| Structure of human Nav1.7 in complex with vixotrigine | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-26 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
8I5G
| Structure of human Nav1.7 in complex with PF-05089771 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-25 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|