1FU5
 
 | | NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE COMPLEXED TO A DOUBLY PHOSPHORYLATED PEPTIDE DERIVED FROM POLYOMAVIRUS MIDDLE T ANTIGEN | | Descriptor: | DOUBLY PHOSPHORYLATED MIDDLE T ANTIGEN, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT | | Authors: | Weber, T, Schaffhausen, B, Liu, Y, Guenther, U.L. | | Deposit date: | 2000-09-14 | | Release date: | 2001-02-21 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site.
Biochemistry, 39, 2000
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1H9O
 | | PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A | | Descriptor: | BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE | | Authors: | Pauptit, R.A, Rowsell, S, Breeze, A.L, Murshudov, G.N, Dennis, C.A, Derbyshire, D.J, Weston, S.A. | | Deposit date: | 2001-03-14 | | Release date: | 2001-03-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | NMR Trial Models: Experiences with the Colicin Immunity Protein Im7 and the P85Alpha C-Terminal Sh2-Peptide Complex
Acta Crystallogr.,Sect.D, 57, 2001
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1G83
 | | CRYSTAL STRUCTURE OF FYN SH3-SH2 | | Descriptor: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN | | Authors: | Arold, S.T, Ulmer, T.S, Mulhern, T.D, Werner, J.M, Ladbury, J.E, Campbell, I.D, Noble, M.E.M. | | Deposit date: | 2000-11-16 | | Release date: | 2001-05-30 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
J.Biol.Chem., 276, 2001
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1JWO
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1KA7
 | | SAP/SH2D1A bound to peptide n-Y-c | | Descriptor: | SH2 DOMAIN PROTEIN 1A, peptide n-Y-c | | Authors: | Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. | | Deposit date: | 2001-10-31 | | Release date: | 2001-11-07 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
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1KA6
 | | SAP/SH2D1A bound to peptide n-pY | | Descriptor: | SH2 DOMAIN PROTEIN 1A, peptide n-pY | | Authors: | Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. | | Deposit date: | 2001-10-31 | | Release date: | 2001-11-07 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
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1IS0
 | | Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor | | Descriptor: | AY0 GLU GLU ILE peptide, Tyrosine-protein kinase transforming protein SRC | | Authors: | Davidson, J.P, Lubman, O, Rose, T, Waksman, G, Martin, S.F. | | Deposit date: | 2001-11-02 | | Release date: | 2002-02-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding.
J.Am.Chem.Soc., 124, 2002
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1KSW
 | | Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP | | Descriptor: | N6-BENZYL ADENOSINE-5'-DIPHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | | Authors: | Witucki, L.A, Huang, X, Shah, K, Liu, Y, Kyin, S, Eck, M.J, Shokat, K.M. | | Deposit date: | 2002-01-14 | | Release date: | 2002-02-27 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.
Chem.Biol., 9, 2002
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1JYQ
 | | Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide | | Descriptor: | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor | | Authors: | Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. | | Deposit date: | 2001-09-13 | | Release date: | 2002-03-13 | | Last modified: | 2018-04-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
J.Mol.Biol., 315, 2002
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1JYR
 | | Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide | | Descriptor: | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN | | Authors: | Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. | | Deposit date: | 2001-09-13 | | Release date: | 2002-03-13 | | Last modified: | 2018-10-10 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
J.Mol.Biol., 315, 2002
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1JYU
 | | Xray Structure of Grb2 SH2 Domain | | Descriptor: | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 | | Authors: | Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. | | Deposit date: | 2001-09-13 | | Release date: | 2002-03-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
J.Mol.Biol., 315, 2002
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1K9A
 | | Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution | | Descriptor: | Carboxyl-terminal Src kinase | | Authors: | Ogawa, A, Takayama, Y, Nagata, A, Chong, K.T, Takeuchi, S, Sakai, H, Nakagawa, A, Nada, S, Okada, M, Tsukihara, T. | | Deposit date: | 2001-10-28 | | Release date: | 2002-03-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the carboxyl-terminal Src kinase, Csk.
J.Biol.Chem., 277, 2002
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1KC2
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1IJR
 | | Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic | | Descriptor: | (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK | | Authors: | Kawahata, N.H, Yang, M.H, Luke, G.P, Shakespeare, W.C, Sundaramoorthi, R. | | Deposit date: | 2001-04-27 | | Release date: | 2002-05-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.
Bioorg.Med.Chem.Lett., 11, 2001
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1JU5
 | | Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy | | Descriptor: | Abl, Crk | | Authors: | Donaldson, L.W, Pawson, T, Kay, L.E, Forman-Kay, J.D. | | Deposit date: | 2001-08-23 | | Release date: | 2002-11-06 | | Last modified: | 2021-11-10 | | Method: | SOLUTION NMR | | Cite: | Structure of a regulatory complex involving the Abl SH3 domain, the Crk
SH2 domain, and a Crk-derived phosphopeptide
Proc.Natl.Acad.Sci.USA, 99, 2002
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1LUI
 | | NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures | | Descriptor: | Tyrosine-protein kinase ITK/TSK | | Authors: | Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M. | | Deposit date: | 2002-05-22 | | Release date: | 2002-11-27 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain
Nat.Struct.Biol., 9, 2002
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1LUK
 | | NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure | | Descriptor: | Tyrosine-protein kinase ITK/TSK | | Authors: | Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. | | Deposit date: | 2002-05-22 | | Release date: | 2002-11-27 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain
Nat.Struct.Biol., 9, 2002
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1LUN
 | | NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure | | Descriptor: | Tyrosine-protein kinase ITK/TSK | | Authors: | Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. | | Deposit date: | 2002-05-22 | | Release date: | 2002-11-27 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain
Nat.Struct.Biol., 9, 2002
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1LUM
 | | NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures | | Descriptor: | Tyrosine-protein kinase ITK/TSK | | Authors: | Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. | | Deposit date: | 2002-05-22 | | Release date: | 2002-11-27 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain
Nat.Struct.Biol., 9, 2002
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1OO4
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1OO3
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1I3Z
 | | MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE | | Descriptor: | EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE | | Authors: | Lu, J, Poy, F, Morra, M, Terhorst, C, Eck, M.J. | | Deposit date: | 2001-02-19 | | Release date: | 2003-04-08 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural basis for the interaction of the free SH2 domain EAT-2 with
SLAM receptors in hematopoietic cells.
Eur.J.Biochem., 20, 2001
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1OPK
 | | Structural basis for the auto-inhibition of c-Abl tyrosine kinase | | Descriptor: | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... | | Authors: | Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. | | Deposit date: | 2003-03-06 | | Release date: | 2003-04-08 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
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1OPL
 | | Structural basis for the auto-inhibition of c-Abl tyrosine kinase | | Descriptor: | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase | | Authors: | Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. | | Deposit date: | 2003-03-06 | | Release date: | 2003-04-08 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.42 Å) | | Cite: | Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
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1NRV
 | | Crystal structure of the SH2 domain of Grb10 | | Descriptor: | Growth factor receptor-bound protein 10 | | Authors: | Stein, E.G, Hubbard, S.R. | | Deposit date: | 2003-01-25 | | Release date: | 2003-04-15 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.
J.Biol.Chem., 278, 2003
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