1JYR

Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide

Summary for 1JYR

Entry DOI	10.2210/pdb1jyr/pdb
Related	1JYQ 1JYU
Descriptor	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN (3 entities in total)
Functional Keywords	receptor binding, regulatory, inhibitor, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	12125.46
Authors	Nioche, P.,Liu, W.-Q.,Broutin, I.,Charbonnier, F.,Latreille, M.-T.,Vidal, M.,Roques, B.,Garbay, C.,Ducruix, A. (deposition date: 2001-09-13, release date: 2002-03-13, Last modification date: 2018-10-10)
Primary citation	Nioche, P.,Liu, W.Q.,Broutin, I.,Charbonnier, F.,Latreille, M.T.,Vidal, M.,Roques, B.,Garbay, C.,Ducruix, A. Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315:1167-1177, 2002 Cited by PubMed: 11827484 DOI: 10.1006/jmbi.2001.5299 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation