1IJR

Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic

Summary for 1IJR

Entry DOI	10.2210/pdb1ijr/pdb
Descriptor	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK, (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID (2 entities in total)
Functional Keywords	tyrosine-protein kinase, transferase-signaling protein complex, transferase/signaling protein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P06239
Total number of polymer chains	1
Total formula weight	12449.84
Authors	Kawahata, N.H.,Yang, M.H.,Luke, G.P.,Shakespeare, W.C.,Sundaramoorthi, R. (deposition date: 2001-04-27, release date: 2002-05-01, Last modification date: 2024-02-07)
Primary citation	Kawahata, N.,Yang, M.G.,Luke, G.P.,Shakespeare, W.C.,Sundaramoorthi, R.,Wang, Y.,Johnson, D.,Merry, T.,Violette, S.,Guan, W.,Bartlett, C.,Smith, J.,Hatada, M.,Lu, X.,Dalgarno, D.C.,Eyermann, C.J.,Bohacek, R.S.,Sawyer, T.K. A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg.Med.Chem.Lett., 11:2319-2323, 2001 Cited by PubMed: 11527723 DOI: 10.1016/S0960-894X(01)00446-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation