PDB: 46044 resultsInfo pagesStatus searchChemie searchBIRD

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7BMC	Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide and stabilizing Fusicoccin A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-01-19 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17, 2022
7NN2	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 41 Descriptor: 14-3-3 protein sigma, 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMW	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 40 Descriptor: 14-3-3 protein sigma, 5-(2-azanylethyl)-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NPG	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 22 Descriptor: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NNE	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 22 Descriptor: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMX	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 12 Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CALCIUM ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NP2	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CHLORIDE ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NND	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 09 Descriptor: 14-3-3 protein sigma, 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NPB	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 09 Descriptor: 14-3-3 protein sigma, 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMA	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CHLORIDE ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
6FN9	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GLYCEROL, ... Authors: Bier, D, Ottmann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome Descriptor: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase Authors: Schumacher, B, Weyand, M, Ottmann, C. Deposit date: 2010-06-21 Release date: 2010-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
8P0D	Human 14-3-3 sigma in complex with human MDM2 peptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. Deposit date: 2023-05-10 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
5BY9	The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2015-06-10 Release date: 2016-04-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (4 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
2NPM	crystal structure of Cryptosporidium parvum 14-3-3 protein in complex with peptide Descriptor: 14-3-3 domain containing protein, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS Authors: Dong, A, Lew, J, Wasney, G, Ren, H, Lin, L, Hassanali, A, Qiu, W, Zhao, Y, Doyle, D, Vedadi, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) Deposit date: 2006-10-27 Release date: 2006-11-07 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
7D9V	CRTC1 pSer245 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer245 peptide, GLYCEROL Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-14 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7D8H	CRTC1 pSer64 peptide in complex with 14-3-3 zeta Descriptor: 14-3-3 protein zeta/delta, CRTC1 pSer64 peptide Authors: Chen, H, Zhang, H, Xiang, S. Deposit date: 2020-10-08 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
7OBC	Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FARNESYL, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OB8	Crystal structure of 14-3-3 sigma in complex with LDB1 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBG	Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-22 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBD	Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FARNESYL, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OB5	Crystal structure of 14-3-3 sigma in complex with LDB1 phosphopeptide Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-21 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBY	Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-24 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBX	Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBT	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide and stabilizer Fusicoccin-A Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... Authors: Centorrino, F, Andlovic, B, Ottmann, C. Deposit date: 2021-04-23 Release date: 2022-05-04 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023

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