7BMC

Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide and stabilizing Fusicoccin A

Summary for 7BMC

Entry DOI	10.2210/pdb7bmc/pdb
Descriptor	14-3-3 protein sigma, VAL-ASN-LEU-SEP-ILE, FUSICOCCIN, ... (6 entities in total)
Functional Keywords	protein-peptide complex, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	29700.09
Authors	Centorrino, F.,Andlovic, B.,Ottmann, C. (deposition date: 2021-01-19, release date: 2022-03-02, Last modification date: 2024-01-31)
Primary citation	Brink, H.J.,van Senten, J.R.,De Vries-van Leeuwen, I.J.,da Costa Pereira, D.,Piersma, S.R.,Jimenez, C.R.,Centorrino, F.,Ottmann, C.,Siderius, M.,Smit, M.J.,de Boer, A.H. Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. Acs Chem.Biol., 17:2972-2978, 2022 Cited by PubMed: 36255265 DOI: 10.1021/acschembio.2c00299 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation