8P0D

Human 14-3-3 sigma in complex with human MDM2 peptide

Summary for 8P0D

• Entry DOI: 10.2210/pdb8p0d/pdb
• Related: 6YR6
• Descriptor: 14-3-3 protein sigma, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ... (7 entities in total)
• Functional Keywords: signaling protein-peptide complex, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 33671.32

Authors

Roversi, P.,Ward, J.,Doveston, R.,Kwon, H.,Romartinez Alonso, B. (deposition date: 2023-05-10, release date: 2024-02-21)

• Primary citation: Ward, J.A.,Romartinez-Alonso, B.,Kay, D.F.,Bellamy-Carter, J.,Thurairajah, B.,Basran, J.,Kwon, H.,Leney, A.C.,Macip, S.,Roversi, P.,Muskett, F.W.,Doveston, R.G.; Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization.; J.Biol.Chem., 300:105651-105651, 2024; PubMed: 38237679; DOI: 10.1016/j.jbc.2024.105651

Experimental method

X-RAY DIFFRACTION (1.31 Å)