7OBD

Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide and stabilizer Fusicoccin-A

Summary for 7OBD

Entry DOI	10.2210/pdb7obd/pdb
Descriptor	14-3-3 protein sigma, Rho-related GTP-binding protein RhoE, FUSICOCCIN, ... (7 entities in total)
Functional Keywords	14-3-3 sigma protein-peptide-stabilizer complex, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	30546.23
Authors	Centorrino, F.,Andlovic, B.,Ottmann, C. (deposition date: 2021-04-21, release date: 2022-05-04, Last modification date: 2024-02-07)
Primary citation	Andlovic, B.,Heilmann, G.,Ninck, S.,Andrei, S.A.,Centorrino, F.,Higuchi, Y.,Kato, N.,Brunsveld, L.,Arkin, M.,Menninger, S.,Choidas, A.,Wolf, A.,Klebl, B.,Kaschani, F.,Kaiser, M.,Eickhoff, J.,Ottmann, C. IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023 Cited by PubMed: 37130519 DOI: 10.1016/j.chembiol.2023.04.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation