7OBY

Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide and stabilizer Fusicoccin-A

Summary for 7OBY

• Entry DOI: 10.2210/pdb7oby/pdb
• Descriptor: 14-3-3 protein sigma, SSBP4 phosphopeptide, FUSICOCCIN, ... (6 entities in total)
• Functional Keywords: 14-3-3 sigma protein protein-peptide-stabilizer complex, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 30259.71

Authors

Centorrino, F.,Andlovic, B.,Ottmann, C. (deposition date: 2021-04-24, release date: 2022-05-04, Last modification date: 2024-02-07)

• Primary citation: Andlovic, B.,Heilmann, G.,Ninck, S.,Andrei, S.A.,Centorrino, F.,Higuchi, Y.,Kato, N.,Brunsveld, L.,Arkin, M.,Menninger, S.,Choidas, A.,Wolf, A.,Klebl, B.,Kaschani, F.,Kaiser, M.,Eickhoff, J.,Ottmann, C.; IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.; Cell Chem Biol, 2023; PubMed: 37130519; DOI: 10.1016/j.chembiol.2023.04.005

Experimental method

X-RAY DIFFRACTION (2.1 Å)