PDB: 594 resultsInfo pagesStatus searchChemie searchBIRD

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5MTM	Monobody Mb(Lck_3) bound to Lck-SH2 domain Descriptor: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION Authors: Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. Deposit date: 2017-01-10 Release date: 2017-04-05 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.405 Å) Cite: Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP Descriptor: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-28 Release date: 2010-12-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
4WWQ	Apo structure of the Grb7 SH2 domain Descriptor: Growth factor receptor-bound protein 7, MALONIC ACID Authors: Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A. Deposit date: 2014-11-12 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
4X6S	Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide Descriptor: Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1 Authors: Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A. Deposit date: 2014-12-09 Release date: 2015-09-23 Last modified: 2015-10-28 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J.Med.Chem., 58, 2015
5MTN	Monobody Mb(Lck_1) bound to Lck-Sh2 Descriptor: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck Authors: Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. Deposit date: 2017-01-10 Release date: 2017-04-05 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
6WM1	Crystal structure of the Grb2 SH2 domain in complex with a tripeptide: Ac-pY-Ac6c-N-phenylpropyl Descriptor: ACE-PTR-02K-ASN-PRA, CALCIUM ION, CHLORIDE ION, ... Authors: Martin, S.F, Clements, J.H. Deposit date: 2020-04-20 Release date: 2020-09-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
2YU7	Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A Descriptor: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A Authors: Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-04-05 Release date: 2008-04-15 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A To be Published
2YSX	Solution structure of the human SHIP SH2 domain Descriptor: Signaling inositol polyphosphate phosphatase SHIP II Authors: Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-04-04 Release date: 2008-04-08 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the human SHIP SH2 domain To be Published
7WFY	Crystal Structure of the VAV2 SH2 domain in complex with APP phosphorylated peptide Descriptor: Amyloid beta A4 protein-binding family B member 1 (protein), Guanine nucleotide exchange factor VAV2 Authors: Zhang, Y.J, Liu, Y.R, Wu, B. Deposit date: 2021-12-27 Release date: 2022-12-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.449 Å) Cite: Vav2 is a novel APP-interacting protein that regulates APP protein level. Sci Rep, 12, 2022
6HTF	Crystal structure of human Btk SH2 domain bound to rF10 repebody Descriptor: Tyrosine-protein kinase BTK, rF10 repebody Authors: Duarte, D.P, Pojer, F, Hantschel, O. Deposit date: 2018-10-04 Release date: 2020-05-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.102 Å) Cite: Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms. Nat Commun, 11, 2020
6ICH	Grb2 SH2 domain in domain swapped dimer form Descriptor: Growth factor receptor-bound protein 2 Authors: Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. Deposit date: 2018-09-06 Release date: 2019-07-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019
3IN7	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: Growth factor receptor-bound protein 2, N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide Authors: Clements, J.H. Deposit date: 2009-08-11 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IMD	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-08-10 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
4QSY	SHP2 SH2 domain in complex with GAB1 peptide Descriptor: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 Authors: Gogl, G, Remenyi, A. Deposit date: 2014-07-06 Release date: 2015-07-08 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling To be Published
8ATK	The SH2 domain of mouse SH2B1 Descriptor: SH2B adapter protein 1 Authors: Fowler, N.J, Williamson, M.P, Albalwi, M.F. Deposit date: 2022-08-23 Release date: 2023-05-24 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: The SH2 domain of SH2B1. Structure, 31, 2023
6R5G	C-SH2 domain of SHP-2 in complex with phospho-ITSM of PD-1 Descriptor: ITSM, Tyrosine-protein phosphatase non-receptor type 11 Authors: Marasco, M. Deposit date: 2019-03-25 Release date: 2020-02-05 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
4ROJ	Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide Descriptor: Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION Authors: Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2014-10-28 Release date: 2014-12-10 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide TO BE PUBLISHED
6ROZ	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif Descriptor: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based switch motif (ITSM) Authors: Krausze, J, Sikorska, J, Carlomagno, T. Deposit date: 2019-05-13 Release date: 2020-02-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
6ROY	Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif Descriptor: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM) Authors: Krausze, J, Sikorska, J, Carlomagno, T. Deposit date: 2019-05-13 Release date: 2020-02-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv, 6, 2020
7Q63	The tandem SH2 domains of SYK Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. Deposit date: 2021-11-05 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The tandem SH2 domains of SYK To Be Published
7Q5W	The tandem SH2 domains of SYK with a bound TYROBP diphospho-ITAM peptide Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, ... Authors: Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. Deposit date: 2021-11-04 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The tandem SH2 domains of SYK To Be Published
4U1P	Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide Descriptor: Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ... Authors: Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. Deposit date: 2014-07-16 Release date: 2015-07-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide To Be Published
4U17	Swapped dimer of the human Fyn-SH2 domain Descriptor: 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn Authors: Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. Deposit date: 2014-07-15 Release date: 2015-07-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Swapped dimer of the human Fyn-SH2 domain To Be Published
4TZI	Structure of unliganded Lyn SH2 domain Descriptor: Tyrosine-protein kinase Lyn Authors: Wybenga-Groot, L.E. Deposit date: 2014-07-10 Release date: 2015-01-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity. Mol.Cell Proteomics, 14, 2015

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