3N84
Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP
Summary for 3N84
Entry DOI | 10.2210/pdb3n84/pdb |
Related | 1BM2 3N7Y |
Descriptor | Growth factor receptor-bound protein 2, 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | ligand preorganization, macrocycles, macrocyclic ligands, golgi apparatus, host-virus interaction, phosphoprotein, protein binding-peptide complex, protein binding/peptide |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus (By similarity): P62993 |
Total number of polymer chains | 12 |
Total formula weight | 83891.99 |
Authors | Clements, J.H.,Martin, S.F. (deposition date: 2010-05-27, release date: 2011-01-12, Last modification date: 2023-11-15) |
Primary citation | Delorbe, J.E.,Clements, J.H.,Whiddon, B.B.,Martin, S.F. Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1:448-452, 2010 Cited by PubMed: 21116482DOI: 10.1021/ml100142y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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