1BM2
GRB2-SH2 DOMAIN IN COMPLEX WITH CYCLO-[N-ALPHA-ACETYL-L-THI ALYSYL-O-PHOSPHOTYROSYL-VALYL-ASPARAGYL-VALYL-PROLYL] (PKF273-791)
Summary for 1BM2
Entry DOI | 10.2210/pdb1bm2/pdb |
Descriptor | PROTEIN (GROWTH FACTOR RECEPTOR BOUND PROTEIN 2), PROTEIN (PKF273-791) (3 entities in total) |
Functional Keywords | sh2 domain, signal transduction, adaptor protein, ras pathway, cyclic peptide, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 14420.26 |
Authors | Rondeau, J.M.,Zurini, M. (deposition date: 1998-07-27, release date: 1998-08-05, Last modification date: 2023-11-15) |
Primary citation | Ettmayer, P.,France, D.,Gounarides, J.,Jarosinski, M.,Martin, M.S.,Rondeau, J.M.,Sabio, M.,Topiol, S.,Weidmann, B.,Zurini, M.,Bair, K.W. Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). J.Med.Chem., 42:971-980, 1999 Cited by PubMed: 10090780DOI: 10.1021/jm9811007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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