2C1B
Structure of cAMP-dependent protein kinase complexed with (4R,2S)-5'-(4-(4-Chlorobenzyloxy)pyrrolidin-2-ylmethanesulfonyl)isoquinoline
Summary for 2C1B
Entry DOI | 10.2210/pdb2c1b/pdb |
Related | 1CMK 1KMU 1KMW 1Q24 1Q61 1Q62 1Q8T 1Q8U 1Q8W 1SMH 1STC 1SVE 1SVG 1SVH 1SZM 1VEB 1YDR 1YDS 1YDT 2C1A |
Descriptor | CAMP-DEPENDENT PROTEIN KINASE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE, ... (4 entities in total) |
Functional Keywords | transferase/inhibitor, complex (transferase-inhibitor), atp-binding, camp, phosphorylation, transferase, serine/threonine-protein kinase, protein kinase inhibitor, transferase-inhibitor complex |
Biological source | BOS TAURUS More |
Cellular location | Cytoplasm : P00517 |
Total number of polymer chains | 2 |
Total formula weight | 43495.96 |
Authors | Collins, I.,Caldwell, J.,Fonseca, T.,Donald, A.,Bavetsias, V.,Hunter, L.J.,Garrett, M.D.,Rowlands, M.G.,Aherne, G.W.,Davies, T.G.,Berdini, V.,Woodhead, S.J.,Seavers, L.C.A.,Wyatt, P.G.,Workman, P.,McDonald, E. (deposition date: 2005-09-12, release date: 2005-11-02, Last modification date: 2018-02-28) |
Primary citation | Collins, I.,Caldwell, J.,Fonseca, T.,Donald, A.,Bavetsias, V.,Hunter, L.J.,Garrett, M.D.,Rowlands, M.G.,Aherne, G.W.,Davies, T.G.,Berdini, V.,Woodhead, S.J.,Davis, D.,Seavers, L.C.,Wyatt, P.G.,Workman, P.,McDonald, E. Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B. Bioorg. Med. Chem., 14:1255-1273, 2006 Cited by PubMed: 16249095DOI: 10.1016/j.bmc.2005.09.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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