1VEB
Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 5
Summary for 1VEB
Entry DOI | 10.2210/pdb1veb/pdb |
Related | 1SVE 1SVG 1SVH |
Descriptor | cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, (3R,4R)-N-{4-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-BENZYLOXY]-AZEPAN-3-YL}-ISONICOTINAMIDE (3 entities in total) |
Functional Keywords | kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase |
Biological source | Bos taurus (cattle) More |
Cellular location | Cytoplasm : P00517 |
Total number of polymer chains | 2 |
Total formula weight | 43506.33 |
Authors | Breitenlechner, C.B.,Wegge, T.,Berillon, L.,Graul, K.,Marzenell, K.,Friebe, W.-G.,Thomas, U.,Schumacher, R.,Huber, R.,Engh, R.A.,Masjost, B. (deposition date: 2004-03-29, release date: 2005-03-29, Last modification date: 2023-12-27) |
Primary citation | Breitenlechner, C.B.,Wegge, T.,Berillon, L.,Graul, K.,Marzenell, K.,Friebe, W.-G.,Thomas, U.,Schumacher, R.,Huber, R.,Engh, R.A.,Masjost, B. Structure-based optimization of novel azepane derivatives as PKB inhibitors J.Med.Chem., 47:1375-1390, 2004 Cited by PubMed: 14998327DOI: 10.1021/jm0310479 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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