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1SVH

Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 8

Summary for 1SVH
Entry DOI10.2210/pdb1svh/pdb
Related1SVE 1SVG 1VEB
DescriptorcAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, (3R,4S)-N-(4-{TRANS-2-[4-(2-FLUORO-6-HYDROXY-3-METHOXY-BENZOYL)-PHENYL]-VINYL}-AZEPAN-3-YL)-ISONICOTINAMIDE, ... (4 entities in total)
Functional Keywordskinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase
Biological sourceBos taurus (cattle)
More
Cellular locationCytoplasm: P00517
Total number of polymer chains2
Total formula weight43422.37
Authors
Breitenlechner, C.B.,Wegge, T.,Berillon, L.,Graul, K.,Marzenell, K.,Friebe, W.G.,Thomas, U.,Schumacher, R.,Huber, R.,Engh, R.A.,Masjost, B. (deposition date: 2004-03-29, release date: 2005-03-29, Last modification date: 2011-07-13)
Primary citationBreitenlechner, C.B.,Wegge, T.,Berillon, L.,Graul, K.,Marzenell, K.,Friebe, W.G.,Thomas, U.,Schumacher, R.,Huber, R.,Engh, R.A.,Masjost, B.
Structure-based optimization of novel azepane derivatives as PKB inhibitors
J.Med.Chem., 47:1375-1390, 2004
Cited by
PubMed: 14998327
DOI: 10.1021/jm0310479
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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